BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 2, 2024
Language: Английский
BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 2, 2024
Language: Английский
Inorganic Chemistry Communications, Journal Year: 2024, Volume and Issue: 168, P. 112952 - 112952
Published: Aug. 7, 2024
Language: Английский
Citations
6BMC Biotechnology, Journal Year: 2025, Volume and Issue: 25(1)
Published: Feb. 20, 2025
Antibiotic resistance is a growing global threat due to antibiotic overuse and limited treatment options. Multidrug-resistant bacteria, like Staphylococcus aureus Escherichia coli, increase infection complexity mortality. This study explores nanocomposite films of ZIF-8 nanoparticles Doxycycline (Dox) enhance antibacterial efficacy. In this study, composed chitosan (CS) polyethylene glycol (PEG), incorporating zeolitic imidazolate framework-8 (ZIF-8) DOX, were developed. These characterized by their morphological, mechanical, antibacterial, drug-release properties. Antibacterial efficacy was evaluated using disk diffusion, broth microdilution, checkerboard assay methods determine MICs potential synergistic effects. The demonstrated flexibility, semi-transparency, yellowish-brown hue, with containing being thicker (79 ± 0.2 μm) than those without (54 0.5 μm). tensile strength enhanced the incorporation ZIF-8, peaking at 53.12 MPa for CS-PEG-G-10% DOX-4% film. XRD analysis confirmed crystallinity distinct peaks observed each material. drug release studies revealed an initial burst followed sustained release, higher rates in acidic environments compared neutral alkaline media. film significantly activity, achieving lowest MIC values, particularly against S. (22.5 mm inhibition zone) E. coli (14 zone). Additionally, notable effect between DOX FICI values below 0.5. exhibits optimal properties, positioning it as strong candidate developing effective treatments multidrug-resistant pathogens.
Language: Английский
Citations
0Materials Science and Engineering B, Journal Year: 2024, Volume and Issue: 310, P. 117681 - 117681
Published: Sept. 5, 2024
Language: Английский
Citations
3Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 5, 2024
Language: Английский
Citations
3International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 276, P. 133810 - 133810
Published: July 14, 2024
Language: Английский
Citations
2BioNanoScience, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 2, 2024
Language: Английский
Citations
0