Nanoparticle-Mediated Embryotoxicity: Mechanisms of Chemical Toxicity and Implications for Biological Development

Chemical Research in Toxicology, Год журнала: 2025, Номер unknown

Опубликована: Март 19, 2025

Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.

Язык: Английский

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Synthesis, Spectral Characterization and Theoretical Evaluation of Azo-Metal Complexes for Potential Antioxidant and Anticancer Activities

Asian Journal of Chemistry, Год журнала: 2025, Номер 37(4), С. 817 - 829

Опубликована: Март 29, 2025

The synthesis and evaluation of azo-metal complexes derived from m-aminophenol 2,4-dihydroxyacetophenone were conducted to investigate their antioxidant anticancer potential. Ligand, 3-(2′,4′-dihydroxy-5-acetylphenylazo)-1-hydroxybenzene (LH2) was synthesized complexed with Cu(II), Ni(II), Co(II) Zn(II) ions. compounds characterized different spectroscopic methods, including FTIR, 1H NMR, 13C ESR, ESI-MS XRD, along thermal analysis (TGA/DTA) SEM-EDS. Antioxidant activity assessed through the DPPH assay revealed that Cu(II) complex showed highest radical scavenging an IC50 13.38 µg/mL, outperforming free ligand (IC50 = 34.57 µg/mL). Anticancer evaluated against MCF-7 (breast cancer cell line) HepG2 (liver lines using MTT assay. Ni(II) demonstrated superior cytotoxicity values 13.48 µg/mL 14.42 respectively, at 48 h, compared standard drug doxorubicin 10.31 Molecular docking studies 17-β-HSD1 indicated strong binding affinities, particularly for (-9.81 kcal/mol), attributed favourable coordination electronic properties. Computational analyses, molecular dynamics simulations HOMO-LUMO energy evaluations, highlighted stability, reactivity interaction potential metal complexes. ADME profiling confirmed drug-likeness, showing promising pharmacokinetic attributes, high gastrointestinal absorption blood-brain barrier permeability.

Язык: Английский

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Fabrication of a nanoplatform based on chitosan and hyaluronic acid containing alkyne-functionalized gold nanoparticles for tumor targeted synergistic phototherapy

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142974 - 142974

Опубликована: Апрель 1, 2025

Язык: Английский

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Novel sulfonamide-based azo-metal complexes: Synthesis, characterization, theoretical studies, and In Vitro antioxidant and anticancer evaluation

Next Materials, Год журнала: 2025, Номер 8, С. 100728 - 100728

Опубликована: Май 20, 2025

Язык: Английский

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Leea macrophylla root extract possess potential cytotoxicity in vitro against HepG2, MCF7 cells and in vivo in EAC xenografted model

Advances in Traditional Medicine, Год журнала: 2025, Номер unknown

Опубликована: Май 21, 2025

Язык: Английский

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Nanotechnology-Enhanced Imaging: Advancing Precision in Fetal Anomaly Detection

Deleted Journal, Год журнала: 2025, Номер unknown

Опубликована: Май 22, 2025

Язык: Английский

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