Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Май 22, 2025
Язык: Английский
Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Май 22, 2025
Язык: Английский
Chemical Research in Toxicology, Год журнала: 2025, Номер unknown
Опубликована: Март 19, 2025
Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.
Язык: Английский
Процитировано
1Asian Journal of Chemistry, Год журнала: 2025, Номер 37(4), С. 817 - 829
Опубликована: Март 29, 2025
The synthesis and evaluation of azo-metal complexes derived from m-aminophenol 2,4-dihydroxyacetophenone were conducted to investigate their antioxidant anticancer potential. Ligand, 3-(2′,4′-dihydroxy-5-acetylphenylazo)-1-hydroxybenzene (LH2) was synthesized complexed with Cu(II), Ni(II), Co(II) Zn(II) ions. compounds characterized different spectroscopic methods, including FTIR, 1H NMR, 13C ESR, ESI-MS XRD, along thermal analysis (TGA/DTA) SEM-EDS. Antioxidant activity assessed through the DPPH assay revealed that Cu(II) complex showed highest radical scavenging an IC50 13.38 µg/mL, outperforming free ligand (IC50 = 34.57 µg/mL). Anticancer evaluated against MCF-7 (breast cancer cell line) HepG2 (liver lines using MTT assay. Ni(II) demonstrated superior cytotoxicity values 13.48 µg/mL 14.42 respectively, at 48 h, compared standard drug doxorubicin 10.31 Molecular docking studies 17-β-HSD1 indicated strong binding affinities, particularly for (-9.81 kcal/mol), attributed favourable coordination electronic properties. Computational analyses, molecular dynamics simulations HOMO-LUMO energy evaluations, highlighted stability, reactivity interaction potential metal complexes. ADME profiling confirmed drug-likeness, showing promising pharmacokinetic attributes, high gastrointestinal absorption blood-brain barrier permeability.
Язык: Английский
Процитировано
0International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 142974 - 142974
Опубликована: Апрель 1, 2025
Язык: Английский
Процитировано
0Next Materials, Год журнала: 2025, Номер 8, С. 100728 - 100728
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0Advances in Traditional Medicine, Год журнала: 2025, Номер unknown
Опубликована: Май 21, 2025
Язык: Английский
Процитировано
0Deleted Journal, Год журнала: 2025, Номер unknown
Опубликована: Май 22, 2025
Язык: Английский
Процитировано
0