Nanoparticle-Mediated Embryotoxicity: Mechanisms of Chemical Toxicity and Implications for Biological Development

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Nanoparticles, defined by their nanoscale dimensions and unique physicochemical properties, are widely utilized in healthcare, electronics, environmental sciences, consumer products. However, increasing evidence of potential embryotoxic effects during pregnancy underscores the need for a molecular-level understanding interactions embryonic development. Nanoparticles such as titanium dioxide, silver, cerium oxide, copper quantum dots can cross placental barrier interfere with crucial developmental processes. At molecular level, they disrupt signaling pathways like Wnt Hedgehog, induce oxidative stress inflammation, cause genotoxic effects, all critical sensitive phases, organogenesis. Furthermore, these nanoparticles interact directly cellular components, including DNA, proteins, lipids, impairing function viability. Innovative strategies to mitigate nanoparticle toxicity, surface modifications incorporation biocompatible coatings, discussed solutions reduce adverse interactions. Various laboratory animal models used investigate nanoparticle-induced embryotoxicity evaluated efficacy limitations, providing insights into applicability effects. This Account examines mechanisms which compromise development emphasizes importance designing safer minimize maternal-fetal exposure risks, particularly biomedical applications.

Language: Английский

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Synthesis, Spectral Characterization and Theoretical Evaluation of Azo-Metal Complexes for Potential Antioxidant and Anticancer Activities

Asian Journal of Chemistry, Journal Year: 2025, Volume and Issue: 37(4), P. 817 - 829

Published: March 29, 2025

The synthesis and evaluation of azo-metal complexes derived from m-aminophenol 2,4-dihydroxyacetophenone were conducted to investigate their antioxidant anticancer potential. Ligand, 3-(2′,4′-dihydroxy-5-acetylphenylazo)-1-hydroxybenzene (LH2) was synthesized complexed with Cu(II), Ni(II), Co(II) Zn(II) ions. compounds characterized different spectroscopic methods, including FTIR, 1H NMR, 13C ESR, ESI-MS XRD, along thermal analysis (TGA/DTA) SEM-EDS. Antioxidant activity assessed through the DPPH assay revealed that Cu(II) complex showed highest radical scavenging an IC50 13.38 µg/mL, outperforming free ligand (IC50 = 34.57 µg/mL). Anticancer evaluated against MCF-7 (breast cancer cell line) HepG2 (liver lines using MTT assay. Ni(II) demonstrated superior cytotoxicity values 13.48 µg/mL 14.42 respectively, at 48 h, compared standard drug doxorubicin 10.31 Molecular docking studies 17-β-HSD1 indicated strong binding affinities, particularly for (-9.81 kcal/mol), attributed favourable coordination electronic properties. Computational analyses, molecular dynamics simulations HOMO-LUMO energy evaluations, highlighted stability, reactivity interaction potential metal complexes. ADME profiling confirmed drug-likeness, showing promising pharmacokinetic attributes, high gastrointestinal absorption blood-brain barrier permeability.

Language: Английский

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Fabrication of a nanoplatform based on chitosan and hyaluronic acid containing alkyne-functionalized gold nanoparticles for tumor targeted synergistic phototherapy

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142974 - 142974

Published: April 1, 2025

Language: Английский

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Novel sulfonamide-based azo-metal complexes: Synthesis, characterization, theoretical studies, and In Vitro antioxidant and anticancer evaluation

Next Materials, Journal Year: 2025, Volume and Issue: 8, P. 100728 - 100728

Published: May 20, 2025

Language: Английский

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Leea macrophylla root extract possess potential cytotoxicity in vitro against HepG2, MCF7 cells and in vivo in EAC xenografted model

Advances in Traditional Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: May 21, 2025

Language: Английский

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Nanotechnology-Enhanced Imaging: Advancing Precision in Fetal Anomaly Detection

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: May 22, 2025

Language: Английский

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