International Dental Journal, Год журнала: 2024, Номер unknown
Опубликована: Окт. 1, 2024
Язык: Английский
Journal of Translational Medicine, Год журнала: 2025, Номер 23(1)
Опубликована: Янв. 22, 2025
Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms signaling pathways. In this review, we delve into the cellular metabolic pathways copper, highlighting role copper biomolecule synthesis, mitochondrial respiration, antioxidant defense. Furthermore, elucidate relationship between cuproptosis-related genes (CRGs) cancer prognosis, analyzing their expression patterns across various tumor types impact on patient outcomes. Our review also uncovers potential therapeutic applications chelators, ionophores, copper-based nanomaterials oncology. addition, discuss emerging cuproptosis remodeling microenvironment, enhancing immune infiltration, converting "cold tumors" "hot that respond better to immunotherapy. short, underscores pivotal importance biology highlights translational a novel target.
Язык: Английский
Процитировано
7
Frontiers in Pharmacology, Год журнала: 2023, Номер 14
Опубликована: Сен. 12, 2023
Copper is an indispensable micronutrient for the development and replication of all eukaryotes, its redox properties are both harmful beneficial to cells. An imbalance in copper homeostasis thought be involved carcinogenesis. Importantly, cancer cell proliferation, angiogenesis, metastasis cannot separated from effects copper. Cuproposis a copper-dependent form death that differs other existing modalities regulatory death. The role cuproptosis pathogenesis nervous cardiovascular systems has been widely studied; however, impact on malignant tumors yet fully understood clinical perspective. Exploring signaling pathways related will undoubtedly provide new perspective anti-tumor drugs future. Here, we systematically review systemic cellular metabolic processes mechanisms cancer. In addition, discuss possibility targeting ion prolong survival patients, with emphasis most representative ionophores chelators. We suggest attention should paid potential value treatment specific cancers.
Язык: Английский
Процитировано
25
Cellular & Molecular Biology Letters, Год журнала: 2024, Номер 29(1)
Опубликована: Июнь 25, 2024
Abstract Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other known death pathways. The molecular underpinnings cuproptosis involve the binding Cu lipoylated enzymes in tricarboxylic acid cycle. This interaction triggers enzyme aggregation and proteotoxic stress, culminating death. specific has yet be fully elucidated. recognized sparked numerous investigations into role tumorigenesis cancer therapy. In this review, we summarized current knowledge on metabolism link cancer. Furthermore, delineated mechanisms roles cuproptosis-related genes Finally, offered comprehensive discussion most recent advancements ionophores nanoparticle delivery systems utilize as cutting-edge strategy for treatment.
Язык: Английский
Процитировано
13
Journal of Materials Chemistry B, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Язык: Английский
Процитировано
2
Cancer Cell International, Год журнала: 2025, Номер 25(1)
Опубликована: Апрель 9, 2025
Hepatocellular carcinoma (HCC) is the main phenotype of liver cancer with a poor prognosis. Copper vital in function, and HCC cells rely on it for growth metastasis, leading to cuproplasia. Excessive copper can induce cell death, termed cuproptosis. Tumor microenvironment (TME) pivotal HCC, especially immunotherapy, closely related TME pathogenesis. However, how these two mechanisms contribute intriguing. We conducted latest progress literature cuproplasia cuproptosis summarized their specific roles treatment strategies. The relationship role have been deeply summarized. Cuproplasia fosters formation, angiogenesis, whereas may alleviate mitochondrial dysfunction hypoxic conditions TME. Inhibiting enhancing are essential achieving therapeutic efficacy HCC. An in-depth analysis within unveils opposing nature impact regulation. Grasping equilibrium between factors crucial deeper understanding shed light novel directions treating
Язык: Английский
Процитировано
1
iMeta, Год журнала: 2024, Номер 3(3)
Опубликована: Апрель 5, 2024
Abstract Recent studies have highlighted the biological significance of cuproptosis in disease occurrence and development. However, it remains unclear whether signaling also has potential impacts on tumor initiation prognosis gastric cancer (GC). In this study, 16 cuproptosis‐related genes (CRGs) transcriptional profiles were harnessed to perform regularized latent variable model‐based clustering GC. A signature risk scoring (CSRS) scheme, based a weighted sum principle components CRGs, was used evaluate individual tumors Four distinct signature‐based clusters, characterized by differential expression patterns identified among 1136 GC samples across three independent databases. The four clusters associated with different clinical outcomes immune contexture. Based CSRS, patients can be divided into CSRS‐High CSRS‐Low subtypes. We found that DBT, MTF1 , ATP7A significantly elevated subtype, while SLC31A1, GCSH, LIAS, DLAT, FDX1, DLD PDHA1 increased subtype. Patients score prolonged survival time. Further analysis indicated correlated greater mutation burden (TMB) higher rates mutated (SMG) addition, subtype harbored more amplified focal regions related tumorigenesis ( 3q27.1, 12p12.1, 11q13.3 etc.) than tumors. Drug sensitivity analyses revealed compounds for treatment score, which experimentally validated using cells. This study highlights subtyping is features molecular landscape Quantitative evaluation CSRS will strengthen our understanding development progress
Язык: Английский
Процитировано
6
Journal of Trace Elements in Medicine and Biology, Год журнала: 2024, Номер 84, С. 127436 - 127436
Опубликована: Март 18, 2024
Язык: Английский
Процитировано
5
International Journal of Oncology, Год журнала: 2024, Номер 64(5)
Опубликована: Март 8, 2024
Breast cancer arises from the malignant transformation of mammary epithelial cells under influence various carcinogenic factors, leading to a gradual increase in its prevalence. This disease has become cause mortality among female malignancies, posing significant threat health women. The timely identification breast remains challenging, often resulting diagnosis at advanced stages disease. Conventional therapeutic approaches, such as surgical excision, chemotherapy and radiotherapy, exhibit limited efficacy controlling progression metastasis Regulated cell death (RCD), process essential for physiological tissue renewal, occurs within body independently external influences. In context cancer, research on RCD primarily focuses cuproptosis, ferroptosis pyroptosis. Mounting evidence suggests marked association between these specific forms RCD, onset cancer. For example, cuproptosis vector can effectively bind copper ions induce cells, thereby hindering their proliferation. Additionally, expression ferroptosis‑related genes enhance sensitivity chemotherapy. Likewise, pyroptosis‑related proteins not only participate pyroptosis, but also regulate tumor microenvironment, ultimately cells. present review discusses unique regulatory mechanisms pyroptosis through which they are affected by conventional drugs. Furthermore, it provides comprehensive overview significance modulating highlights shared characteristics. knowledge may provide novel avenues both clinical interventions fundamental
Язык: Английский
Процитировано
4
Archives of Biochemistry and Biophysics, Год журнала: 2025, Номер unknown, С. 110324 - 110324
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Discovery Medicine, Год журнала: 2024, Номер 36(182), С. 457 - 457
Опубликована: Янв. 1, 2024
Chitosan seems to be an innovative biological material potentially utilized as a nanoparticle carrier for drug delivery, which could low toxic, biocompatible, and easy prepare. nanoparticles have been employed in gene delivery. As type of multifunctional adjuvant, chitosan activate the phosphoinositide 3-kinase (PI3K)/AKT signaling pathway induce cell protection and/or proliferation via modulation autophagy within dendritic cells. In general, adjuvants may improve innate adaptive immune responses vaccine antigen by facilitating presentation presenting cells such The choice suitable adjuvant has become vital improved safety expanded application vaccines. Fortunately, designed target enhanced its effect stimulating robust responses. Therefore, good stimulant with encouraging properties development superior Indeed, vaccines play key role human health. this review, we summarize concept recent progress field nanoparticles, providing valuable resource investigating molecular mechanisms greater vaccine.
Язык: Английский
Процитировано
1