International Dental Journal, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 1, 2024
Language: Английский
Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)
Published: Jan. 22, 2025
Cuproptosis differs from other forms of cell death, such as apoptosis, necroptosis, and ferroptosis, in its unique molecular mechanisms signaling pathways. In this review, we delve into the cellular metabolic pathways copper, highlighting role copper biomolecule synthesis, mitochondrial respiration, antioxidant defense. Furthermore, elucidate relationship between cuproptosis-related genes (CRGs) cancer prognosis, analyzing their expression patterns across various tumor types impact on patient outcomes. Our review also uncovers potential therapeutic applications chelators, ionophores, copper-based nanomaterials oncology. addition, discuss emerging cuproptosis remodeling microenvironment, enhancing immune infiltration, converting "cold tumors" "hot that respond better to immunotherapy. short, underscores pivotal importance biology highlights translational a novel target.
Language: Английский
Citations
7
Journal of Materials Chemistry B, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review discusses the recent developments in copper-based nanomaterials that utilize copper-induced cell death, categorized by materials systems, while highlighting limitations of current cuproptosis related nanomaterials.
Language: Английский
Citations
2
Cellular & Molecular Biology Letters, Journal Year: 2024, Volume and Issue: 29(1)
Published: June 25, 2024
Abstract Cuproptosis, a newly identified copper (Cu)-dependent form of cell death, stands out due to its distinct mechanism that sets it apart from other known death pathways. The molecular underpinnings cuproptosis involve the binding Cu lipoylated enzymes in tricarboxylic acid cycle. This interaction triggers enzyme aggregation and proteotoxic stress, culminating death. specific has yet be fully elucidated. recognized sparked numerous investigations into role tumorigenesis cancer therapy. In this review, we summarized current knowledge on metabolism link cancer. Furthermore, delineated mechanisms roles cuproptosis-related genes Finally, offered comprehensive discussion most recent advancements ionophores nanoparticle delivery systems utilize as cutting-edge strategy for treatment.
Language: Английский
Citations
11
Frontiers in Pharmacology, Journal Year: 2023, Volume and Issue: 14
Published: Sept. 12, 2023
Copper is an indispensable micronutrient for the development and replication of all eukaryotes, its redox properties are both harmful beneficial to cells. An imbalance in copper homeostasis thought be involved carcinogenesis. Importantly, cancer cell proliferation, angiogenesis, metastasis cannot separated from effects copper. Cuproposis a copper-dependent form death that differs other existing modalities regulatory death. The role cuproptosis pathogenesis nervous cardiovascular systems has been widely studied; however, impact on malignant tumors yet fully understood clinical perspective. Exploring signaling pathways related will undoubtedly provide new perspective anti-tumor drugs future. Here, we systematically review systemic cellular metabolic processes mechanisms cancer. In addition, discuss possibility targeting ion prolong survival patients, with emphasis most representative ionophores chelators. We suggest attention should paid potential value treatment specific cancers.
Language: Английский
Citations
22
Journal of Trace Elements in Medicine and Biology, Journal Year: 2024, Volume and Issue: 84, P. 127436 - 127436
Published: March 18, 2024
Language: Английский
Citations
5
iMeta, Journal Year: 2024, Volume and Issue: 3(3)
Published: April 5, 2024
Abstract Recent studies have highlighted the biological significance of cuproptosis in disease occurrence and development. However, it remains unclear whether signaling also has potential impacts on tumor initiation prognosis gastric cancer (GC). In this study, 16 cuproptosis‐related genes (CRGs) transcriptional profiles were harnessed to perform regularized latent variable model‐based clustering GC. A signature risk scoring (CSRS) scheme, based a weighted sum principle components CRGs, was used evaluate individual tumors Four distinct signature‐based clusters, characterized by differential expression patterns identified among 1136 GC samples across three independent databases. The four clusters associated with different clinical outcomes immune contexture. Based CSRS, patients can be divided into CSRS‐High CSRS‐Low subtypes. We found that DBT, MTF1 , ATP7A significantly elevated subtype, while SLC31A1, GCSH, LIAS, DLAT, FDX1, DLD PDHA1 increased subtype. Patients score prolonged survival time. Further analysis indicated correlated greater mutation burden (TMB) higher rates mutated (SMG) addition, subtype harbored more amplified focal regions related tumorigenesis ( 3q27.1, 12p12.1, 11q13.3 etc.) than tumors. Drug sensitivity analyses revealed compounds for treatment score, which experimentally validated using cells. This study highlights subtyping is features molecular landscape Quantitative evaluation CSRS will strengthen our understanding development progress
Language: Английский
Citations
5
International Journal of Oncology, Journal Year: 2024, Volume and Issue: 64(5)
Published: March 8, 2024
Breast cancer arises from the malignant transformation of mammary epithelial cells under influence various carcinogenic factors, leading to a gradual increase in its prevalence. This disease has become cause mortality among female malignancies, posing significant threat health women. The timely identification breast remains challenging, often resulting diagnosis at advanced stages disease. Conventional therapeutic approaches, such as surgical excision, chemotherapy and radiotherapy, exhibit limited efficacy controlling progression metastasis Regulated cell death (RCD), process essential for physiological tissue renewal, occurs within body independently external influences. In context cancer, research on RCD primarily focuses cuproptosis, ferroptosis pyroptosis. Mounting evidence suggests marked association between these specific forms RCD, onset cancer. For example, cuproptosis vector can effectively bind copper ions induce cells, thereby hindering their proliferation. Additionally, expression ferroptosis‑related genes enhance sensitivity chemotherapy. Likewise, pyroptosis‑related proteins not only participate pyroptosis, but also regulate tumor microenvironment, ultimately cells. present review discusses unique regulatory mechanisms pyroptosis through which they are affected by conventional drugs. Furthermore, it provides comprehensive overview significance modulating highlights shared characteristics. knowledge may provide novel avenues both clinical interventions fundamental
Language: Английский
Citations
4
Archives of Biochemistry and Biophysics, Journal Year: 2025, Volume and Issue: unknown, P. 110324 - 110324
Published: Feb. 1, 2025
Language: Английский
Citations
0
Cancer Cell International, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 9, 2025
Hepatocellular carcinoma (HCC) is the main phenotype of liver cancer with a poor prognosis. Copper vital in function, and HCC cells rely on it for growth metastasis, leading to cuproplasia. Excessive copper can induce cell death, termed cuproptosis. Tumor microenvironment (TME) pivotal HCC, especially immunotherapy, closely related TME pathogenesis. However, how these two mechanisms contribute intriguing. We conducted latest progress literature cuproplasia cuproptosis summarized their specific roles treatment strategies. The relationship role have been deeply summarized. Cuproplasia fosters formation, angiogenesis, whereas may alleviate mitochondrial dysfunction hypoxic conditions TME. Inhibiting enhancing are essential achieving therapeutic efficacy HCC. An in-depth analysis within unveils opposing nature impact regulation. Grasping equilibrium between factors crucial deeper understanding shed light novel directions treating
Language: Английский
Citations
0
BMC Cancer, Journal Year: 2024, Volume and Issue: 24(1)
Published: June 28, 2024
Metal-regulatory transcription factor 1 (MTF1), a conserved metal-binding in eukaryotes, regulates the proliferation of cancer cells by activating downstream target genes and then participates formation progression tumors, including lung (LC). The expression level MTF1 is down-regulated LC, high associated with good prognosis LC. However, association between polymorphism LC risk has not been explored.
Language: Английский
Citations
1