KPNA2/KPNB1 promotes the malignant progression of gastric cancer induced by M2 macrophage polarization

Tissue and Cell, Год журнала: 2024, Номер 93, С. 102714 - 102714

Опубликована: Дек. 31, 2024

Язык: Английский

Causal relationship between immune cells and bladder cancer: a bi-directional Mendelian randomization study

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Июнь 26, 2024

Background and Objectives: Previous studies have explored the role of immune cells on bladder cancer（BCa）. This bi-directional Mendelian randomization (MR) study further assessed 731 immunocyte phenotypes whether BCa a causal relationship exists provides some evidence causality. Methods: The summary data for cell was derived from cohort, including 3,757 individuals Sardinia with phenotypes. were obtained their respective genome-wide association (GWAS). We used inverse variable weighting (IVW) as primary analysis method. In addition, we simultaneously employed multiple analytical methods, MR-Egger, weighted mode, simple median, to strengthen final results. Finally, sensitivity analyses conducted verify stability feasibility data. Results: 16 traits involving four immunological signal types (MFI, RC, AC, MP) shown be significantly correlated risk in our investigation. positively 5 (P < 0.05, OR > 1); However, remainder incidence decreases by 11 (OR<1, P<0.05). Furthermore, none them revealed reverse causality, heterogeneity, or horizontal pleiotropy 0.05). Conclusions: Through comprehensive MR analysis, able reveal complicated link between several BCa, focusing intricate network interactions system BCa. results this provide fresh viewpoints resources investigating immunotherapeutic targets preventive tactics.

Язык: Английский

Construction of M2 macrophage-related gene signature for predicting prognosis and revealing different immunotherapy response in bladder cancer patients

Clinical & Translational Oncology, Год журнала: 2024, Номер unknown

Опубликована: Сен. 30, 2024

Язык: Английский