KPNA2/KPNB1 promotes the malignant progression of gastric cancer induced by M2 macrophage polarization
Juan Bai,
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Ping Chen,
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Qingxia Zhou
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et al.
Tissue and Cell,
Journal Year:
2024,
Volume and Issue:
93, P. 102714 - 102714
Published: Dec. 31, 2024
Language: Английский
Causal relationship between immune cells and bladder cancer: a bi-directional Mendelian randomization study
AnNeng HY,
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Zongying Lv,
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Guiyuan Chen
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et al.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 26, 2024
Abstract
Background
and
Objectives:
Previous
studies
have
explored
the
role
of
immune
cells
on
bladder
cancer（BCa）.
This
bi-directional
Mendelian
randomization
(MR)
study
further
assessed
731
immunocyte
phenotypes
whether
BCa
a
causal
relationship
exists
provides
some
evidence
causality.
Methods:
The
summary
data
for
cell
was
derived
from
cohort,
including
3,757
individuals
Sardinia
with
phenotypes.
were
obtained
their
respective
genome-wide
association
(GWAS).
We
used
inverse
variable
weighting
(IVW)
as
primary
analysis
method.
In
addition,
we
simultaneously
employed
multiple
analytical
methods,
MR-Egger,
weighted
mode,
simple
median,
to
strengthen
final
results.
Finally,
sensitivity
analyses
conducted
verify
stability
feasibility
data.
Results:
16
traits
involving
four
immunological
signal
types
(MFI,
RC,
AC,
MP)
shown
be
significantly
correlated
risk
in
our
investigation.
positively
5
(P
<
0.05,
OR
>
1);
However,
remainder
incidence
decreases
by
11
(OR<1,
P<0.05).
Furthermore,
none
them
revealed
reverse
causality,
heterogeneity,
or
horizontal
pleiotropy
0.05).
Conclusions:
Through
comprehensive
MR
analysis,
able
reveal
complicated
link
between
several
BCa,
focusing
intricate
network
interactions
system
BCa.
results
this
provide
fresh
viewpoints
resources
investigating
immunotherapeutic
targets
preventive
tactics.
Language: Английский
Construction of M2 macrophage-related gene signature for predicting prognosis and revealing different immunotherapy response in bladder cancer patients
Zhouting Tuo,
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Mingzhu Gao,
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Chao Jiang
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et al.
Clinical & Translational Oncology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Sept. 30, 2024
Language: Английский