Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer’s Disease Inflammation

Antioxidants, Год журнала: 2024, Номер 13(2), С. 177 - 177

Опубликована: Янв. 31, 2024

Resveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol proinflammatory monomeric C-reactive protein (mCRP). mCRP increases risk AD after stroke and we previously demonstrated that intracerebral induces AD-like dementia mice. Here, used BV2 microglia treated for 24 h presence or absence resveratrol. Cells conditioned media were collected analysis. Lipopolysaccharide (LPS) has also been implicated progression so LPS was as resveratrol-sensitive reference agent. at concentration 50 µg/mL activated nitric oxide pathway NLRP3 inflammasome pathway. Furthermore, induced cyclooxygenase-2 release cytokines. effectively inhibited these changes increased expression antioxidant enzyme genes Cat Sod2. As central defense, hub Sirt1 Nfe2l2 nuclear translocation signal transducer NF-ĸB. Proinflammatory by primary mixed glial cultures protected This work provides mechanistic insight into preventing agents.

Язык: Английский

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Study of Characterization, Antimicrobial, and Anticancer Potential of Albumin-Baicalin Nanoparticles in Hep3B Liver Cancer Cell Lines

BioNanoScience, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 10, 2025

Язык: Английский

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Plant-Derived Bioactive Compounds in the Management of Neurodegenerative Disorders: Challenges, Future Directions and Molecular Mechanisms Involved in Neuroprotection

Pharmaceutics, Год журнала: 2023, Номер 15(3), С. 749 - 749

Опубликована: Фев. 23, 2023

Neurodegenerative disorders encompass a wide range of pathological conditions caused by progressive damage to the neuronal cells and nervous-system connections, which primarily target dysfunction result in problems with mobility, cognition, coordination, sensation, strength. Molecular insights have revealed that stress-related biochemical alterations such as abnormal protein aggregation, extensive generation reactive oxygen nitrogen species, mitochondrial dysfunction, neuroinflammation may lead cells. Currently, no neurodegenerative disease is curable, available standard therapies can only provide symptomatic treatment delay progression disease. Interestingly, plant-derived bioactive compounds drawn considerable attention due their well-established medicinal properties, including anti-apoptotic, antioxidant, anti-inflammatory, anticancer, antimicrobial well neuroprotective, hepatoprotective, cardioprotective, other health benefits. Plant-derived received far more recent decades than synthetic many diseases, neurodegeneration. By selecting suitable and/or plant formulations, we fine tune because therapeutic efficacy drugs greatly enhanced combinations. A plethora vitro vivo studies demonstrated compounds' immense potential, proven capacity influence expression activity numerous proteins implicated oxidative stress, neuroinflammation, apoptosis, aggregation. Thus, this review mostly focuses on anti-aggregation, anti-cholinesterase, anti-apoptotic properties several formulations molecular mechanisms against disorders.

Язык: Английский

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Novel antioxidant peptides identified from coix seed by molecular docking, quantum chemical calculations and invitro study in HepG2 cells

Food Chemistry, Год журнала: 2023, Номер 440, С. 138234 - 138234

Опубликована: Дек. 20, 2023

Язык: Английский

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Mechanistic insight into neuroprotective effect of standardized ginger chemo varieties from Manipur, India in scopolamine induced learning and memory impaired mice

Metabolic Brain Disease, Год журнала: 2025, Номер 40(1)

Опубликована: Янв. 15, 2025

Язык: Английский

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Combined Donepezil with Astaxanthin via Nanostructured Lipid Carriers Effective Delivery to Brain for Alzheimer’s Disease in Rat Model

International Journal of Nanomedicine, Год журнала: 2023, Номер Volume 18, С. 4193 - 4227

Опубликована: Июль 1, 2023

Introduction: Donepezil (DPL), a specific acetylcholinesterase inhibitor, is used as first-line treatment to improve cognitive deficits in Alzheimer's disease (AD) and it might have modifying effect. Astaxanthin (AST) natural potent antioxidant with neuroprotective, anti-amyloidogenic, anti-apoptotic, anti-inflammatory effects. This study aimed prepare nanostructured lipid carriers (NLCs) co-loaded donepezil astaxanthin (DPL/AST–NLCs) evaluate their vivo efficacy an AD-like rat model 30 days after daily intranasal administration. Methods: DPL/AST–NLCs were prepared using hot high-shear homogenization technique, vitro examined for physicochemical parameters evaluated. AD induction rats was performed by aluminum chloride. The cortex hippocampus isolated from the brain of biochemical testing histopathological examination. Results: showed z-average diameter 149.9 ± 3.21 nm, polydispersity index 0.224 0.017, zeta potential – 33.7 4.71 mV, entrapment efficiency 81.25 1.98% (donepezil) 93.85 1.75% (astaxanthin), sustained release both 24 h, spherical morphology transmission electron microscopy, they stable at 4– 8 2°C six months. Differential scanning calorimetry revealed that molecularly dispersed NLC matrix amorphous state. DPL/AST–NLC-treated significantly lower levels nuclear factor-kappa B, malondialdehyde, β-site amyloid precursor protein cleaving enzyme-1, caspase-3, beta (Aβ 1‑42 ), acetylcholinesterase, higher glutathione acetylcholine than untreated treated donepezil–NLCs. antioxidant, anti-acetylcholinesterase, anti-inflammatory, anti-apoptotic effects, resulting significant improvement cortical hippocampal histopathology. Conclusion: Nose-to-brain delivery promising strategy management AD. Keywords: disease, donepezil, astaxanthin, delivery,

Язык: Английский

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Outcome of resveratrol and resveratrol with donepezil combination on the β-amyloid plaques and neurofibrillary tangles in Alzheimer’s disease

3 Biotech, Год журнала: 2024, Номер 14(8)

Опубликована: Авг. 1, 2024

The goal of this research was to study the effect different doses resveratrol (RS) and RS with donepezil (DPZ) on deposition amyloid beta (Aβ) neurofibrillary tangles (NFTs) in colchicine-induced Alzheimer's disease (AD) brain. included three months old male Albino

Язык: Английский

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Therapeutic Potential of Plant Based HMG CoA Reductase Inhibitor-Berberine for Alzheimer’s Disease in ICV Induced Streptozotocin Rodent Model

Indian Journal of Pharmaceutical Education and Research, Год журнала: 2025, Номер 59(1), С. 153 - 163

Опубликована: Янв. 6, 2025

Background Alzheimer's Disease (AD), is a progressive neurodegenerative disease, that results in memory loss, cognitive impairment and behavioral abnormalities. It one of the most widely spread diseases common among elders. In AD there an increase generation ROS, RNS phosphorylation TAU. As result, efforts to produce medications have centered on lowering levels Aβ (Amyoid β). Cholesterol stabilizes β-secretase γ-secretase promotes amyloidogenesis. Aim The current work evaluated therapeutic potential plant-based berberine for clearance rodent model via HMG CoA reductase inhibitory action. Materials Methods olfactory sensibility (Buried pellet test), spatial (Morris water maze) recognition (Novel Object Recognition Test-NORT) were used evaluate berberines' protective effects using female C57BL/6 mice. was reported Streptozotocin (STZ) causes loss dysregulation lipid metabolism. Results investigation showed encouraging slowing progression by reducing deposition. combination Donepezil (DPZ-3.5 mg/kg BBR-100 mg/kg/p.o) had significant improvement parameters such as agility function. BBR (100 mg/kg) has shown decrease (40%) total cholesterol compared disease group. Additionally, group treated with alone reduction amyloid Conclusion This study shows slows regulating metabolism result deposition amyloid.

Язык: Английский

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Resveratrol Protects Photoreceptors in Mouse Models of Retinal Degeneration

Antioxidants, Год журнала: 2025, Номер 14(2), С. 154 - 154

Опубликована: Янв. 28, 2025

Photoreceptor/retinal degeneration is the major cause of blindness. Induced and inherited mouse models retinal are valuable tools for investigating disease mechanisms developing therapeutic interventions. This study investigated potential antioxidant resveratrol to relieve photoreceptor using models. Clinical studies have shown a association between thyroid hormone (TH) signaling age-related degeneration. Excessive TH induces oxidative stress/damage death in mice. C57BL/6 (rod-dominant) Nrl−/− (cone-dominant) mice at postnatal day 30 (P30) received triiodothyronine (T3) via drinking water (20 µg/mL) with or without concomitant treatment (120 days, followed by evaluation degeneration, damage, stress responses. In experiments Leber congenital amaurosis model mice, mother Rpe65−/− Rpe65−/−/Nrl−/− 20 days 10–13 respectively, beginning on when pups were P5, then evaluated cone Treatment significantly diminished induced T3 preserved photoreceptors Rpe65-deficient manifested as morphology/outer nuclear layer thickness, increased density, reduced apoptosis, upregulation genes involved cell death/inflammatory responses, macroglial activation. These findings demonstrate role associated Rpe65 deficiency, support resveratrol/antioxidants management

Язык: Английский

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Neuroprotective Potentials Of Extracts From Moringa Oleifera And Musa Sapientum Against Cadmium Chloride-Induced Neurotoxicity In Rats Cerebri

Journal of Experimental and Molecular Biology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 7, 2025

Cadmium (Cd)-exposure in humans causes nervous system dysfunctions. In rats, Cd-exposure resulted increases of nitric oxide and lipid peroxidation levels the hippocampus. This study evaluated neuroprotective potential active drug compounds extracted from Moringa oleifera leaves (MO11) Musa sapientum suckers (MS06) cadmium chloride (CdCl2)-induced neurotoxicity rats. Adult male Wistar rats totalling 24 number, were grouped randomly into six with four per group. Group 1 served as control. An intraperitoneal single-dose CdCl2 was administered to Groups 2 4 6 on Day 1. MO11-dose, MO11+MS06-doses, Doxorubicin-dose respectively 3, 4, for post-treatment CdCl2-induced neurotoxicity. Rats 5 Olive Oil-dose (vehicle) 17 days. Tissue concentrations catalase, superoxide dismutase, cyclo-oxygenase-2 cytochrome P450 rats’ cerebri determined using ELISA. Statistical analyses (p ≤ 0.05) data conducted Mann-Whitney U Test. Results showed increased catalase levels, similar dismutase decreased comparison 2. The tested extracts impacted some neuroprotection, neuroregeneration, antioxidant anticancer capacities against caused by exposure.

Язык: Английский

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