Molecules,
Год журнала:
2024,
Номер
29(22), С. 5314 - 5314
Опубликована: Ноя. 11, 2024
Alzheimer's
disease
(AD)
involves
a
complex
pathophysiology
with
multiple
interconnected
subpathologies,
including
protein
aggregation,
impaired
neurotransmission,
oxidative
stress,
and
microglia-mediated
neuroinflammation.
Current
treatments,
which
generally
target
single
subpathology,
have
failed
to
modify
the
disease's
progression,
providing
only
temporary
symptom
relief.
Multi-target
drugs
(MTDs)
address
several
aggregation
of
pathological
proteins.
In
this
review,
we
cover
hybrid
molecules
published
between
2014
2024.
We
offer
an
overview
strategies
employed
in
drug
design
approaches
that
led
notable
improvements
reduced
hepatotoxicity.
Our
aim
is
insights
into
potential
development
new
drugs.
This
highlights
multi-target
featuring
heterocycles
Alzheimer s & Dementia,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 27, 2025
Abstract
Alzheimer's
disease
(AD)
is
a
degenerative
characterized
by
progressive
cognitive
dysfunction.
The
strong
link
between
nutrition
and
the
occurrence
progression
of
AD
pathology
has
been
well
documented.
Poor
nutritional
status
accelerates
progress
potentially
aggravating
amyloid
beta
(Aβ)
tau
deposition,
exacerbating
oxidative
stress
response,
modulating
microbiota–gut–brain
axis,
disrupting
blood–brain
barrier
function.
advanced
stage
tends
to
lead
malnutrition
due
impairments,
sensory
dysfunctions,
brain
atrophy,
behavioral
psychological
symptoms
dementia
(BPSD).
This,
in
turn,
produces
vicious
cycle
AD.
This
review
discusses
how
factors
deteriorate
each
other
from
early
terminal
stages
AD,
focusing
on
potential
different
levels
factors,
ranging
micronutrients
diet
patterns.
provides
novel
insights
into
reducing
risk
delaying
its
progression,
improving
prognosis.
Highlights
Two‐fifths
cases
worldwide
have
attributed
modifiable
factors.
Up
≈26%
community‐dwelling
patients
with
are
malnourished,
compared
7%∼76%
institutionalized
patients.
Undernutrition
effects
onset,
prognosis
through
multiple
mechanisms.
Various
supports
were
confirmed
be
protective
for
via
specific
Applied Sciences,
Год журнала:
2024,
Номер
14(11), С. 4534 - 4534
Опубликована: Май 25, 2024
Resveratrol
(RSV),
a
naturally
occurring
phytoalexin,
is
the
most
important
stilbenoid
synthesized
by
plants
as
defense
mechanism
in
response
to
microbial
aggression,
toxins,
or
ultraviolet
radiation.
RSV
came
attention
of
researchers
both
potential
chemopreventive
agent
and
possible
explanation
for
low
incidence
cardiovascular
disease
(CVD)
French
people
with
high-fat
diet.
mainly
administered
food
supplement,
its
properties
are
evaluated
vitro
vivo
on
various
experimental
models.
modulates
signaling
pathways
that
limit
spread
tumor
cells,
protects
nerve
cells
from
damage,
useful
prevention
diabetes,
generally
acts
an
anti-aging
natural
compound.
It
was
highlighted
could
ameliorate
consequences
unhealthy
lifestyle
caused
exaggerated
caloric
intake.
This
paper
reviews
evidence
supporting
beneficial
effect
pathological
conditions,
e.g.,
neoplastic
diseases,
neurodegeneration,
metabolic
syndrome,
obesity,
CVDs,
immune
bacterial,
viral,
fungal
infections.
The
study
also
focused
chromatographic
analysis
trans-RSV
(tRSV)
Romanian
wine
samples,
providing
comprehensive
overview
tRSV
content
across
different
types
wine.
ACS Chemical Neuroscience,
Год журнала:
2024,
Номер
15(16), С. 2966 - 2981
Опубликована: Июль 31, 2024
Sinapic
acid
(SA)
is
a
phenylpropanoid
derivative
found
in
various
natural
sources
that
exhibits
remarkable
versatile
properties,
including
antioxidant,
anti-inflammatory,
and
metal-chelating
capabilities,
establishing
itself
as
promising
candidate
for
the
prevention
treatment
of
conditions
affecting
central
nervous
system,
such
Alzheimer's
disease
(AD),
Parkinson's
(PD),
ischemic
stroke,
other
neurological
disorders.
These
effects
also
include
neuroprotection
epilepsy
models,
evidenced
by
reduction
seizure-like
behavior,
cell
death
specific
hippocampal
regions,
lowered
neuroinflammatory
markers.
In
AD,
SA
enhances
memory,
reverses
cognitive
deficits,
attenuates
astrocyte
activation.
has
positive
on
cognition
improving
memory
lowering
oxidative
stress.
This
shown
lower
levels
stress
markers,
higher
antioxidant
enzyme
activity,
better
retention.
Additionally,
stroke
PD
provides
microglial
protection
exerts
anti-inflammatory
effects.
review
emphasizes
SA's
multifaceted
neuroprotective
properties
its
potential
role
brain
Despite
need
further
research
to
fully
understand
mechanisms
action
clinical
applicability,
stands
out
valuable
bioactive
compound
ongoing
quest
combat
neurodegenerative
diseases
enhance
quality
life
affected
individuals.
Nutrients,
Год журнала:
2025,
Номер
17(7), С. 1203 - 1203
Опубликована: Март 29, 2025
Alzheimer's
disease
(AD)
is
a
complex
neurodegenerative
disorder
characterized
by
progressive
cognitive
decline,
memory
loss,
and
behavioral
changes.
It
poses
significant
global
health
challenge.
AD
associated
with
the
accumulation
of
amyloid-β
(Aβ)
plaques
neurofibrillary
tangles
(NFTs)
in
brain,
along
chronic
inflammation,
dysfunctional
neurons,
synapse
loss.
While
prevalence
continues
to
rise,
current
FDA-approved
drugs
offer
only
limited
effectiveness.
Emerging
evidence
suggests
that
obesity,
insulin
resistance
(IR),
type
2
diabetes
mellitus
(T2DM)
are
also
implicated
pathogenesis,
epidemiological
studies
animal
models
confirming
impact
IR
on
Aβ
accumulation,
high-fat
diets
exacerbating
accumulation.
Since
neuroinflammation
activated
involves
nuclear
factor
kappa-light-chain-enhancer
B
cell
(NF-κB)
pathway,
inhibition
NF-κB
NLRP3
inflammasome
activation
potential
therapeutic
strategies
AD.
Bioactive
compounds,
including
polyphenols
(resveratrol,
epigallocatechin-3-gallate,
curcumin,
quercetin),
omega-3
polyunsaturated
fatty
acids,
show
promising
results
clinical
trials
for
reducing
levels,
improving
cognition
modulating
signaling
pathways
This
review
explores
interplay
between
IR,
pathology,
emphasizing
dietary
compounds
their
role
oxidative
stress,
as
viable
prevention
treatment.
By
integrating
findings,
observational
studies,
trials,
this
aims
provide
comprehensive
understating
how
metabolic
dysfunctions
bioactive
influence
progression.
Resveratrol
(RSV),
a
naturally
occurring
phytoalexin,
is
the
most
important
stilbenoid
synthesized
by
plants,
as
defense
mechanism,
in
response
to
microbial
aggression,
toxins
or
ultraviolet
radiation.
RSV
came
attention
of
researchers
both
potential
chemopreventive
agent
and
possible
explanation
for
low
incidence
cardiovascular
disease
(CVD)
French
people
with
high-fat
diet.
mainly
administered
food
supplement,
its
properties
being
evaluated
vitro
vivo,
on
various
experimental
models.
modulates
signaling
pathways
that
limit
spread
tumor
cells,
protects
nerve
cells
from
damage,
useful
prevention
diabetes,
generally
acts
an
anti-aging
natural
compound.
It
was
highlighted
could
ameliorate
consequences
unhealthy
lifestyle
caused
exaggerated
caloric
intake.
This
paper
reviews
evidence
supporting
beneficial
effect
pathological
conditions,
e.g.,
neoplastic
diseases,
neurodegeneration,
metabolic
syndrome,
obesity,
CVDs,
immune
bacterial,
viral,
fungal
infections.
The
study
also
focused
chromatographic
analysis
trans-RSV
(tRSV)
Romanian
wine
samples,
providing
comprehensive
overview
tRSV
content
across
different
types
wine.
Foods,
Год журнала:
2024,
Номер
13(18), С. 2886 - 2886
Опубликована: Сен. 12, 2024
Atherosclerosis
(AS)
is
a
chronic
inflammatory
vascular
disease.
Dysregulated
lipid
metabolism,
oxidative
stress,
and
inflammation
are
the
major
mechanisms
implicated
in
development
of
AS.
In
addition,
evidence
suggests
that
gut
dysbiosis
plays
an
important
role
atherogenesis,
modulation
microbiota
with
probiotics
phenolic
compounds
has
emerged
as
promising
strategy
for
preventing
treating
It
been
shown
can
improve
atherosclerosis-related
parameters
by
improving
profile,
inflammation.
these
may
modulate
diversity
composition
atherosclerosis.
The
studies
evaluated
present
review
showed
compounds,
when
consumed
individually,
improved
atherosclerosis
modulating
various
ways,
such
decreasing
permeability,
TMAO
LPS
levels,
altering
alpha
beta
diversity,
increasing
fecal
bile
acid
loss.
However,
no
study
was
found
combined
use
to
available
literature
highlights
synergistic
potential
between
their
health-promoting
properties
functionalities.
This
aims
summarize
on
individual
effects
AS,
while
providing
insights
into
benefits
nutraceutical
approaches
using
probiotic
strains,
quercetin,
resveratrol
adjuvant
therapies
AS
treatment
through
microbiota.
Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Сен. 24, 2024
Nrf2
is
a
master
transcriptional
regulator
of
number
genes
involved
in
the
adaptive
response
to
oxidative
stress.
Among
upregulated
by
Nrf2,
heme
oxygenase-1
(HO-1)
has
received
significant
attention,
given
that
products
HO-1-induced
catabolism
have
well
established
antioxidant
and
anti-inflammatory
properties.
This
evidenced
numerous
models
inflammatory
autoimmune
disease
whereby
induction
HO-1
expression
or
administration
tolerable
amounts
reaction
can
ameliorate
symptoms.
Unsurprisingly,
are
now
considered
viable
drug
targets
for
conditions.
In
recent
years,
term
‘inflammaging’
been
used
describe
low-grade
chronic
inflammation
observed
aging/aged
cells.
Increased
stress
also
key
factor
associated
with
aging
there
convincing
evidence
not
only
declines
age,
but
reduce
cellular
senescence
senescence-associated
secretory
phenotype
(SASP)
which
an
underlying
driver
age-related
disease.
this
review,
we
role
highlight
potential
anti-aging
properties
Nrf2-HO-1
system.
We
newly
emerging
activators
their
therapeutic
application
Journal of Integrative Neuroscience,
Год журнала:
2025,
Номер
24(1)
Опубликована: Янв. 20, 2025
Alzheimer’s
disease
(AD)
is
a
common
central
neurodegenerative
disorder
characterized
primarily
by
cognitive
impairment
and
non-cognitive
neuropsychiatric
symptoms
that
significantly
impact
patients’
daily
lives
behavioral
functioning.
The
pathogenesis
of
AD
remains
unclear
current
Western
medicines
treatment
are
purely
symptomatic,
with
singular
pathway,
limited
efficacy,
substantial
toxicity
side
effects.
In
recent
years,
as
research
into
has
deepened,
there
been
gradual
increase
in
the
exploration
application
medicinal
plants
for
AD.
Numerous
studies
have
shown
their
active
ingredients
can
potentially
mitigate
regulating
various
molecular
mechanisms,
including
production
aggregation
pathological
proteins,
oxidative
stress,
neuroinflammation,
apoptosis,
mitochondrial
dysfunction,
neurogenesis,
neurotransmission,
brain-gut
microbiota
axis.
this
review,
we
analyzed
comprehensively
summarized
advancements
on
AD,
along
underlying
mechanisms
clinical
evidence.
Ultimately,
aimed
to
provide
reference
further
investigation
specific
through
which
prevent
treat
well
identification
efficacious
derived
from
plants.
Molecules,
Год журнала:
2025,
Номер
30(3), С. 555 - 555
Опубликована: Янв. 26, 2025
Quinazoline,
a
privileged
scaffold
in
medicinal
chemistry,
offers
promising
potential
the
synthesis
of
anti-Alzheimer’s
disease
(AD)
drugs.
This
heterocyclic
compound,
characterized
by
its
fused
benzene
and
pyrimidine
rings,
enables
design
multifunctional
agents
targeting
AD
pathology.
The
drug-like
aspects
pharmaceutical
features
quinazoline
derivatives
have
to
give
rise
various
therapeutic
is
progressive
neurodegenerative
condition
marked
memory
decline,
cognitive
deterioration,
language
disorders.
Given
complexity
multifaceted
nature,
there
pressing
need
discover
multi-target
drugs
effectively
address
this
debilitating
disorder.
A
comprehensive
literature
review
has
demonstrated
that
exhibit
wide
range
for
AD.
These
compounds
function
as
inhibitors
cholinesterases,
β-amyloid
aggregation,
oxidative
stress,
tau
protein,
among
other
protective
effects.
Here,
we
highlight
most
significant
recent
research
on
quinazoline-based
anti-AD
agents,
aiming
support
development
discovery
novel
treatments
