Research Square (Research Square),
Год журнала:
2023,
Номер
unknown
Опубликована: Июнь 1, 2023
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
has
been
demonstrated
to
infect
various
mammals,
including
cats,
dogs,
and
minks.
Given
the
close
coexistence
of
humans
transmission
SARS-CoV-2
variants
between
these
two
species
documented.
This
study
involved
sampling
eight
domestic
cats
that
resided
solely
with
their
infected
owners
in
Brazil,
during
early
stage
Omicron
variant
wave.
Nasal
anal
secretion
samples
obtained
from
were
subjected
RT-qPCR
analysis,
which
revealed
no
detection
SARS-CoV-2.
Additionally,
serum
collected
did
not
show
presence
anti-SARS-CoV-2
antibodies.
The
findings
this
indicate
a
low
potential
felines,
contributes
absence
transmission.
Therefore,
do
appear
play
significant
role
chain
In
late
2022
and
early
2023,
SARS-CoV-2
infections
were
detected
on
three
mink
farms
in
Poland
situated
within
a
few
km
from
each
other.
Whole-genome
sequencing
of
the
viruses
two
showed
that
they
related
to
virus
identified
humans
same
region
2
years
before
(B.1.1.307
lineage).
Many
mutations
found,
including
S
protein
typical
adaptations
host.
The
origin
remains
be
determined.
Nature Communications,
Год журнала:
2023,
Номер
14(1)
Опубликована: Ноя. 30, 2023
The
COVID-19
pandemic
has
profoundly
impacted
health
systems
globally
and
robust
surveillance
been
critical
for
control,
however
not
all
countries
can
currently
sustain
community
pathogen
programs.
Wastewater
proven
valuable
in
high-income
settings,
but
less
is
known
about
the
utility
of
water
pathogens
low-income
countries.
Here
we
show
how
wastewater
SAR-CoV-2
be
used
to
identify
temporal
changes
help
determine
circulating
variants
quickly.
In
Malawi,
a
country
with
limited
community-based
testing
capacity,
explore
rivers
SARS-CoV-2
surveillance.
From
May
2020-May
2022,
collect
from
up
112
river
or
defunct
treatment
plant
sites,
detecting
8.3%
samples.
Peak
detection
samples
predate
peaks
clinical
cases.
Sequencing
identified
Beta,
Delta,
Omicron
variants,
Delta
detected
well
advance
patients.
Our
work
highlights
detect
emerging
waves,
concern,
provide
an
early
warning
system
settings
no
formal
sewage
systems.
Journal of General Virology,
Год журнала:
2023,
Номер
104(12)
Опубликована: Дек. 7, 2023
Repeat
spillover
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
into
new
hosts
has
highlighted
the
critical
role
cross-species
transmission
coronaviruses
and
establishment
reservoirs
virus
in
pandemic
epizootic
spread
coronaviruses.
Species
particularly
susceptible
to
SARS-CoV-2
include
Mustelidae
(mink,
ferrets
related
animals),
cricetid
rodents
(hamsters
felids
(domestic
cats
animals)
white-tailed
deer.
These
predispositions
led
us
screen
British
wildlife
with
sarbecovirus-specific
quantitative
PCR
pan
assays
for
using
samples
collected
during
human
establish
if
widespread
was
occurring.
Fourteen
species
(
Abstract
The
severe
acute
respiratory
syndrome
coronavirus-2
(SARS-CoV-2)
infection
is
the
cause
of
coronavirus
disease
2019
(COVID-19);
a
distress
that
has
emerged
from
city
Wuhan,
Hubei
province,
China
during
December
2019.
COVID-19
currently
major
global
health
problem
and
now
spread
to
most
countries
in
world.
profoundly
impacted
human
activities
worldwide.
Genetic
mutation
one
essential
characteristics
viruses.
They
do
so
adapt
their
host
or
move
another
one.
Viral
genetic
mutations
have
high
potentiality
impact
as
these
grant
viruses
unique
unpredicted
characteristics.
difficulty
predicting
viral
significant
obstacle
field.
Evidence
indicates
SARS-CoV-2
variety
genomic
diversity
with
obvious
clinical
consequences
implications.
In
this
review,
we
comprehensively
summarized
discussed
available
knowledge
regarding
outbreaks
fundamental
focus
on
role
proteins
progression.
We
also
implications
variants
how
they
affect
severity
hinder
vaccine
development.
Finally,
provided
massive
phylogenetic
analysis
spike
gene
214
isolates
different
geographical
regions
all
over
world
associated
Emerging infectious diseases,
Год журнала:
2024,
Номер
30(2)
Опубликована: Янв. 18, 2024
We
report
an
outbreak
of
COVID-19
in
a
beaver
farm
Mongolia
2021.
Genomic
characterization
revealed
unique
combination
mutations
the
SARS-CoV-2
infected
beavers.
Based
on
these
findings,
increased
surveillance
farmed
beavers
should
be
encouraged.
Diethylnitrosamine
(DEN),
a
common
dietary
carcinogen,
is
associated
with
neurotoxicity
in
humans
and
animals.
This
study
investigated
the
neuroprotective
effects
of
diphenyl
diselenide
(DPDS)
against
DEN-induced
male
Albino
Wistar
rats
(n
=
40).
Rats
were
randomly
distributed
into
cohorts
treated
as
follows:
vehicle
control
(corn
oil
2
mL/kg;
gavage),
DPDS-only
(5
mg/kg;
gavage)
DEN-only
(200
single
dose
i.p.).
Also,
two
other
rat
pre-treated
DPDS
(3
or
5
mg/kg)
for
15
days
(day:
0–15),
subsequently
administered
DEN
continuously
another
7
days,
(days:15–21).
Behavioural
tests
(OFT-
using
open
field
test;
NORT-
novel
object
recognition
FST-
forced
swimming
test
Y-maze)
conducted
from
19–21,
followed
by
biochemical
analysis
hippocampus
prefrontal
cortex
oxidative
stress,
inflammation,
neurotransmitter
metabolic
enzyme,
histopathology.
DEN-treated
exhibited
decreased
locomotor
activity,
spatial
memory
function
antioxidant
increased
nitration
anxiety,
depressive-like
behaviour,
causing
histoarchitectural
damage
hippocampal
cortices.
treatment
(pre-
post-DEN
exposure)
significantly
alleviated
these
neurotoxic,
oxidative,
effects,
reversed
histopathological
alterations,
improved
locomotive
cognitive
functions.
In
conclusion,
demonstrates
potent
toxicity,
likely
through
enhanced
endogenous
capacity
that
mitigates
oxido-nitrative
damage.
These
findings
suggest
organo-selenium
-DPDS-
promising
chemotherapeutic
agent
alleviating
DEN-mediated
maintaining
brain
health.
Viruses,
Год журнала:
2024,
Номер
16(4), С. 617 - 617
Опубликована: Апрель 16, 2024
Reverse
zoonotic
transmission
events
of
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
have
been
described
since
the
start
pandemic,
and
World
Organisation
for
Animal
Health
(WOAH)
designated
detection
SARS-CoV-2
in
animals
a
reportable
disease.
Eighteen
domestic
zoo
Great
Britain
Jersey
were
tested
by
APHA
during
2020-2023.
One
cat
(Felis
catus),
three
dogs
(Canis
lupus
familiaris),
Amur
tigers
(Panthera
tigris
altaica)
from
confirmed
positive
2020-2021
reported
to
WOAH.
All
seven
linked
with
known
human
contacts.
Characterisation
variants
genome
sequencing
indicated
that
was
infected
an
early
lineage.
The
Delta
variant
concern
(B.1.617.2).
role
non-human
species
onward
emergence
new
remain
poorly
defined.
Continued
surveillance
relevant
captive
animal
high
levels
contact
is
important
monitor
at
human-animal
interface
assess
their
as
potential
reservoirs.
