No detection of SARS-CoV-2 in domestic cats exposed to infected owners during the Omicron Wave in São Paulo, Brazil DOI Creative Commons
Luciano Rodrigo Lopes, Paula Ordonhez Rigato, Silvana Kasinski

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: June 1, 2023

Abstract Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been demonstrated to infect various mammals, including cats, dogs, and minks. Given the close coexistence of humans transmission SARS-CoV-2 variants between these two species documented. This study involved sampling eight domestic cats that resided solely with their infected owners in Brazil, during early stage Omicron variant wave. Nasal anal secretion samples obtained from were subjected RT-qPCR analysis, which revealed no detection SARS-CoV-2. Additionally, serum collected did not show presence anti-SARS-CoV-2 antibodies. The findings this indicate a low potential felines, contributes absence transmission. Therefore, do appear play significant role chain

Language: Английский

Cryptic SARS-CoV-2 lineage identified on two mink farms as a possible result of long-term undetected circulation in an unknown animal reservoir, Poland, November 2022 to January 2023 DOI Creative Commons
Katarzyna Domańska-Blicharz, Bas B. Oude Munnink, Anna Orłowska

et al.

Eurosurveillance, Journal Year: 2023, Volume and Issue: 28(16)

Published: April 20, 2023

In late 2022 and early 2023, SARS-CoV-2 infections were detected on three mink farms in Poland situated within a few km from each other. Whole-genome sequencing of the viruses two showed that they related to virus identified humans same region 2 years before (B.1.1.307 lineage). Many mutations found, including S protein typical adaptations host. The origin remains be determined.

Language: Английский

Citations

25
Utilizing river and wastewater as a SARS-CoV-2 surveillance tool in settings with limited formal sewage systems DOI Creative Commons
Kayla G. Barnes, Joshua I. Levy, Jillian Gauld

et al.

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Nov. 30, 2023

The COVID-19 pandemic has profoundly impacted health systems globally and robust surveillance been critical for control, however not all countries can currently sustain community pathogen programs. Wastewater proven valuable in high-income settings, but less is known about the utility of water pathogens low-income countries. Here we show how wastewater SAR-CoV-2 be used to identify temporal changes help determine circulating variants quickly. In Malawi, a country with limited community-based testing capacity, explore rivers SARS-CoV-2 surveillance. From May 2020-May 2022, collect from up 112 river or defunct treatment plant sites, detecting 8.3% samples. Peak detection samples predate peaks clinical cases. Sequencing identified Beta, Delta, Omicron variants, Delta detected well advance patients. Our work highlights detect emerging waves, concern, provide an early warning system settings no formal sewage systems.

Language: Английский

Citations

24
Synthesis and evolution of 16-membered macrolide carrimycin derivatives as a novel class of anti-HCoV-OC43 agents targeting viral FSE RNA DOI
Xiuli Zhong,

Zhihui Yu,

Runze Meng

et al.

European Journal of Medicinal Chemistry, Journal Year: 2025, Volume and Issue: 287, P. 117373 - 117373

Published: Feb. 7, 2025

Language: Английский

Citations

1
Lack of detection of SARS-CoV-2 in British wildlife 2020–21 and first description of a stoat (Mustela erminea) Minacovirus DOI
Ternenge Apaa, Amy J. Withers, Laura MacKenzie

et al.

Journal of General Virology, Journal Year: 2023, Volume and Issue: 104(12)

Published: Dec. 7, 2023

Repeat spillover of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into new hosts has highlighted the critical role cross-species transmission coronaviruses and establishment reservoirs virus in pandemic epizootic spread coronaviruses. Species particularly susceptible to SARS-CoV-2 include Mustelidae (mink, ferrets related animals), cricetid rodents (hamsters felids (domestic cats animals) white-tailed deer. These predispositions led us screen British wildlife with sarbecovirus-specific quantitative PCR pan assays for using samples collected during human establish if widespread was occurring. Fourteen species (

Language: Английский

Citations

11
SARS-CoV-2 outbreak: role of viral proteins and genomic diversity in virus infection and COVID-19 progression DOI Creative Commons
Hosni A. M. Hussein, Ali A. Thabet,

Ahmed A. Wardany

et al.

Virology Journal, Journal Year: 2024, Volume and Issue: 21(1)

Published: March 27, 2024

Abstract The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection is the cause of coronavirus disease 2019 (COVID-19); a distress that has emerged from city Wuhan, Hubei province, China during December 2019. COVID-19 currently major global health problem and now spread to most countries in world. profoundly impacted human activities worldwide. Genetic mutation one essential characteristics viruses. They do so adapt their host or move another one. Viral genetic mutations have high potentiality impact as these grant viruses unique unpredicted characteristics. difficulty predicting viral significant obstacle field. Evidence indicates SARS-CoV-2 variety genomic diversity with obvious clinical consequences implications. In this review, we comprehensively summarized discussed available knowledge regarding outbreaks fundamental focus on role proteins progression. We also implications variants how they affect severity hinder vaccine development. Finally, provided massive phylogenetic analysis spike gene 214 isolates different geographical regions all over world associated

Language: Английский

Citations

3
Structure Elucidation and Computational Studies of the Thiazole Derivative Against SARS-CoV-2 Virus: Insights from XRD, DFT, Molecular Docking, and Molecular Dynamics Simulation DOI

Karthik Venkatesh,

Ravi Singh K.,

T.N. Lohith

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: 1322, P. 140550 - 140550

Published: Oct. 31, 2024

Language: Английский

Citations

3
SARS-CoV-2 Infection in Beaver Farm, Mongolia, 2021 DOI Creative Commons

Taichiro Takemura,

Ulaankhuu Ankhanbaatar, Tirumala Bharani K. Settypalli

et al.

Emerging infectious diseases, Journal Year: 2024, Volume and Issue: 30(2)

Published: Jan. 18, 2024

We report an outbreak of COVID-19 in a beaver farm Mongolia 2021. Genomic characterization revealed unique combination mutations the SARS-CoV-2 infected beavers. Based on these findings, increased surveillance farmed beavers should be encouraged.

Language: Английский

Citations

2
Adverse events associated with SARS-CoV-2 neutralizing monoclonal antibodies using the FDA adverse event reporting system database DOI

Min Joung Choi,

Sehun Oh, Yun‐Kyoung Song

et al.

Toxicological Research, Journal Year: 2024, Volume and Issue: 40(4), P. 673 - 682

Published: July 30, 2024

Language: Английский

Citations

1
Diethyl nitrosamine-induces neurobehavioral deficit, oxido-nitrosative stress in rats' brain: a neuroprotective role of diphenyl diselenide DOI Creative Commons
Solomon E. Owumi, Joseph Chimezie,

Praise Dyap Emmanuel

et al.

BMC Neuroscience, Journal Year: 2024, Volume and Issue: 25(1)

Published: Dec. 25, 2024

Diethylnitrosamine (DEN), a common dietary carcinogen, is associated with neurotoxicity in humans and animals. This study investigated the neuroprotective effects of diphenyl diselenide (DPDS) against DEN-induced male Albino Wistar rats (n = 40). Rats were randomly distributed into cohorts treated as follows: vehicle control (corn oil 2 mL/kg; gavage), DPDS-only (5 mg/kg; gavage) DEN-only (200 single dose i.p.). Also, two other rat pre-treated DPDS (3 or 5 mg/kg) for 15 days (day: 0–15), subsequently administered DEN continuously another 7 days, (days:15–21). Behavioural tests (OFT- using open field test; NORT- novel object recognition FST- forced swimming test Y-maze) conducted from 19–21, followed by biochemical analysis hippocampus prefrontal cortex oxidative stress, inflammation, neurotransmitter metabolic enzyme, histopathology. DEN-treated exhibited decreased locomotor activity, spatial memory function antioxidant increased nitration anxiety, depressive-like behaviour, causing histoarchitectural damage hippocampal cortices. treatment (pre- post-DEN exposure) significantly alleviated these neurotoxic, oxidative, effects, reversed histopathological alterations, improved locomotive cognitive functions. In conclusion, demonstrates potent toxicity, likely through enhanced endogenous capacity that mitigates oxido-nitrative damage. These findings suggest organo-selenium -DPDS- promising chemotherapeutic agent alleviating DEN-mediated maintaining brain health.

Language: Английский

Citations

1
Detection of SARS-CoV-2 Delta Variant (B.1.617.2) in Domestic Dogs and Zoo Tigers in England and Jersey during 2021 DOI Creative Commons
Amanda H. Seekings, Rebecca Shipley, Alexander M. P. Byrne

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(4), P. 617 - 617

Published: April 16, 2024

Reverse zoonotic transmission events of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been described since the start pandemic, and World Organisation for Animal Health (WOAH) designated detection SARS-CoV-2 in animals a reportable disease. Eighteen domestic zoo Great Britain Jersey were tested by APHA during 2020-2023. One cat (Felis catus), three dogs (Canis lupus familiaris), Amur tigers (Panthera tigris altaica) from confirmed positive 2020-2021 reported to WOAH. All seven linked with known human contacts. Characterisation variants genome sequencing indicated that was infected an early lineage. The Delta variant concern (B.1.617.2). role non-human species onward emergence new remain poorly defined. Continued surveillance relevant captive animal high levels contact is important monitor at human-animal interface assess their as potential reservoirs.

Language: Английский

Citations

0