Recent TRAIL Engineering Strategies for Precise Strike Therapy Against Tumor

Biomaterials Research, Год журнала: 2025, Номер 29

Опубликована: Янв. 1, 2025

Effective drug delivery relies on the selection of suitable carriers, which is crucial for protein-based therapeutics such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). One key advantages TRAIL its ability to selectively induce apoptosis in cancer cells excluding healthy tissues by binding death receptors DR4 and DR5, are highly expressed various cells. Despite this promise, clinical application has been limited short half-life, stability, inefficient sites. To overcome currently available engineering approaches, a series sophisticated strategies required: (a) design biomaterial-mediated carriers enhanced targeting efficacy, particularly via optimizing selected materials, composition, formulation, surface modulation. Moreover, (b) development genetically modified cellular products augmented secretion toward microenvironments (c) cell techniques immobilization onto infusible populations also discussed present review. Among these living cell-based offer distinct advantage systemically administered TRAIL-functionalized capturing circulating bloodstream, thereby preventing secondary formation. This review provides insight into novel platforms, discusses considerations translation, suggests future directions complementary advance field TRAIL-based therapeutics.

Язык: Английский

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Bioinspired Suction-Driven Strategies with Nanoscale Skin-Controllable Adhesive Architectures for Efficient Liquid Formulated Transdermal Patches

ACS Nano, Год журнала: 2025, Номер unknown

Опубликована: Апрель 2, 2025

For highly efficient and precise drug release, transdermal delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome significant difficulties in delivering large molecule drugs nanomaterials due physical barrier skin, especially stratum corneum, traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms provided innovative solutions these challenges. employ negative pressure enhance nanoscale skin-controllable skin adhesion, temporarily bypass barrier, facilitate deep penetration therapeutic agents, thereby, achieving goals increasing efficiency maximizing user convenience as a minimal invasive, needle-free platform. This review provides comprehensive overview patches emphasizes their integration multifunctional materials achieve stable controlled release. Next, we present cost-effective user-friendly patch devices optimization cupping without incorporation additional devices. Furthermore, that optimize need for Potential SDAs localized systemic challenging complex well future perspectives, discussed, along directions more patient-centric solutions.

Язык: Английский

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Localized Cancer Treatment Using Thiol–Ene Hydrogels for Dual Drug Delivery

Biomacromolecules, Год журнала: 2025, Номер unknown

Опубликована: Апрель 8, 2025

Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% 33%). Rheological analysis confirmed enhanced viscoelasticity increasing (99Gel-33 > 99Gel-16 23Gel-33 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) carvacrol (CRV), exhibiting tumor-responsive degradation tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% PBS), while CRV showed an initial burst followed sustained promoted mesenchymal stem cell proliferation effectively inhibited triple-negative breast cells. injectable, offers promising platform minimally invasive, personalized therapy.

Язык: Английский

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Synthesis, Characterization and Therapeutic Advancements in Cyclodextrin-Based Drug Delivery Systems for Oncology: A Review

Carbohydrate Polymer Technologies and Applications, Год журнала: 2025, Номер unknown, С. 100814 - 100814

Опубликована: Май 1, 2025

Язык: Английский

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Enhanced secretion of growth factors from ADSCs using an enzymatic antioxidant hydrogel in inflammatory environments and its therapeutic effect

Journal of Controlled Release, Год журнала: 2024, Номер 377, С. 301 - 314

Опубликована: Ноя. 23, 2024

Язык: Английский

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