Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 301 - 314
Published: Nov. 23, 2024
Language: Английский
Biomaterials Research, Journal Year: 2025, Volume and Issue: 29
Published: Jan. 1, 2025
Effective drug delivery relies on the selection of suitable carriers, which is crucial for protein-based therapeutics such as tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). One key advantages TRAIL its ability to selectively induce apoptosis in cancer cells excluding healthy tissues by binding death receptors DR4 and DR5, are highly expressed various cells. Despite this promise, clinical application has been limited short half-life, stability, inefficient sites. To overcome currently available engineering approaches, a series sophisticated strategies required: (a) design biomaterial-mediated carriers enhanced targeting efficacy, particularly via optimizing selected materials, composition, formulation, surface modulation. Moreover, (b) development genetically modified cellular products augmented secretion toward microenvironments (c) cell techniques immobilization onto infusible populations also discussed present review. Among these living cell-based offer distinct advantage systemically administered TRAIL-functionalized capturing circulating bloodstream, thereby preventing secondary formation. This review provides insight into novel platforms, discusses considerations translation, suggests future directions complementary advance field TRAIL-based therapeutics.
Language: Английский
Citations
0
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: April 2, 2025
For highly efficient and precise drug release, transdermal delivery systems (TDDS) have recently evolved through the combination of intelligent material-based structures with various active components. These strategies are an effort to overcome significant difficulties in delivering large molecule drugs nanomaterials due physical barrier skin, especially stratum corneum, traditional TDDS. Interestingly, multiscale suction-driven architectures (SDAs) inspired by bioinspired suction adhesion mechanisms provided innovative solutions these challenges. employ negative pressure enhance nanoscale skin-controllable skin adhesion, temporarily bypass barrier, facilitate deep penetration therapeutic agents, thereby, achieving goals increasing efficiency maximizing user convenience as a minimal invasive, needle-free platform. This review provides comprehensive overview patches emphasizes their integration multifunctional materials achieve stable controlled release. Next, we present cost-effective user-friendly patch devices optimization cupping without incorporation additional devices. Furthermore, that optimize need for Potential SDAs localized systemic challenging complex well future perspectives, discussed, along directions more patient-centric solutions.
Language: Английский
Citations
0
Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Combinatorial cancer therapy benefits from injectable hydrogels for localized, controlled drug delivery. This study presents a thiol-ene conjugated hydrogel formed by cross-linking thiol-modified hyaluronic acid (HASH) with vinyl sulfone-modified β-cyclodextrin (CDVS). Four formulations (23Gel-16, 23Gel-33, 99Gel-16, 99Gel-33) were synthesized varying HASH molecular weight (23 or 99 kDa) and CDVS modification (16% 33%). Rheological analysis confirmed enhanced viscoelasticity increasing (99Gel-33 > 99Gel-16 23Gel-33 23Gel-16). The system enabled combinatorial delivery of doxorubicin (DOX) carvacrol (CRV), exhibiting tumor-responsive degradation tunable release. DOX release accelerated under tumor-mimicking conditions (100% in 46 h vs 58.7% PBS), while CRV showed an initial burst followed sustained promoted mesenchymal stem cell proliferation effectively inhibited triple-negative breast cells. injectable, offers promising platform minimally invasive, personalized therapy.
Language: Английский
Citations
0
Carbohydrate Polymer Technologies and Applications, Journal Year: 2025, Volume and Issue: unknown, P. 100814 - 100814
Published: May 1, 2025
Language: Английский
Citations
0
Journal of Controlled Release, Journal Year: 2024, Volume and Issue: 377, P. 301 - 314
Published: Nov. 23, 2024
Language: Английский
Citations
1