Herbal concoction Unveiled: A computational analysis of phytochemicals' pharmacokinetic and toxicological profiles using novel approach methodologies (NAMs)

Current Research in Toxicology, Год журнала: 2023, Номер 5, С. 100118 - 100118

Опубликована: Янв. 1, 2023

Herbal medications have an extensive history of use in treating various diseases, attributed to their perceived efficacy and safety. Traditional medicine practitioners contemporary healthcare providers shown particular interest herbal syrups, especially for respiratory illnesses associated with the SARS-CoV-2 virus. However, current understanding pharmacokinetic toxicological properties phytochemicals these mixtures is limited. This study presents a comprehensive computational analysis utilizing novel approach methodologies (NAMs) investigate profiles syrup, leveraging in-silico techniques prediction tools such as PubChem, SwissADME, Molsoft's database. Although molecular dynamics, docking, broader system-wide analyses were not considered, future studies hold potential further investigation areas. By combining drug-likeness simulation, researchers identify diverse suitable complex medication development examining pharmacokinetic-toxicological phytopharmaceutical syrup. The focuses on solutions infections, goal adding pool all-natural treatments ailments. research has revolutionize environmental alternative by models innovative analytical enhanced therapeutic benefits explore network-based systems biology approaches deeper interactions biological systems. Overall, our offers valuable insights into concoction. paves way advancements medicine. we acknowledge need address aforementioned topics that adequately covered this research.

Язык: Английский

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Natural Products from Herbal Medicine Self‐Assemble into Advanced Bioactive Materials

Advanced Science, Год журнала: 2024, Номер unknown

Опубликована: Июль 21, 2024

Novel biomaterials are becoming more crucial in treating human diseases. However, many materials require complex artificial modifications and synthesis, leading to potential difficulties preparation, side effects, clinical translation. Recently, significant progress has been achieved terms of direct self-assembly natural products from herbal medicine (NPHM), an important source for novel medications, resulting a wide range bioactive supramolecular including gels, nanoparticles. The NPHM-based produced renewable resources, simple prepare, have demonstrated multi-functionality slow-release, smart-responsive release, especially possess powerful biological effects treat various In this review, revealed as emerging, revolutionary, promising strategy. development, advantages, limitations NPHM, well the advantageous position materials, first reviewed. Subsequently, systematic comprehensive analysis strategies specific seven major classes NPHM is highlighted. Insights into influence structural features on formation also provided. Finally, drivers preparations summarized, emphasizing biomedical applications, future scientific challenges, opportunities, with hope igniting inspiration research applications.

Язык: Английский

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Impact of Heavy Metal Pollution in the Environment on the Metabolic Profile of Medicinal Plants and Their Therapeutic Potential

Plants, Год журнала: 2024, Номер 13(6), С. 913 - 913

Опубликована: Март 21, 2024

The paper provides a comprehensive examination of heavy metal stress on medicinal plants, focusing its impact antioxidant capacity and biosynthetic pathways critical to their therapeutic potential. It explores the complex relationship between metals physiological biochemical responses highlighting how disrupts pathways, altering concentrations secondary metabolites. This disruption may compromise overall quality efficacy requiring holistic understanding cumulative impacts. Furthermore, study discusses potential targeted genetic editing enhance plant resilience against by manipulating genes associated with defenses. approach represents promising frontier in safeguarding plants metal-contaminated environments. Additionally, research investigates role phytohormone signaling adaptive mechanisms stress, revealing influence responses, thereby adding complexity adaptation. underscores importance innovative technologies global cooperation protecting plants’ highlights need for mitigation strategies address contamination effectively.

Язык: Английский

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More Than Pigments: The Potential of Astaxanthin and Bacterioruberin-Based Nanomedicines

Pharmaceutics, Год журнала: 2023, Номер 15(7), С. 1828 - 1828

Опубликована: Июнь 26, 2023

Carotenoids are natural products regulated by the food sector, currently used as feed dyes and antioxidants in dietary supplements composing functional foods for human consumption. Of nearly one thousand carotenoids described to date, only retinoids, derived from beta carotene, have status of a drug pharmaceutical sector. In this review, we address novel field: transformation xanthophylls, particularly highly marketed astaxanthin practically unknown bacterioruberin, therapeutic agents altering their pharmacokinetics, biodistribution, pharmacodynamics through formulation nanomedicines. The antioxidant activity xanthophylls is mediated routes different those classical oral anti-inflammatory drugs such corticosteroids non-steroidal (NSAIDs): remarkably, lack but also toxicity. Formulated nanomedicines, gain mechanisms other than increased bioavailability. Loaded into ad hoc tailored nanoparticles protect structure throughout storage during gastrointestinal transit or skin penetration, can be targeted delivered selected inflamed cell groups, achieving massive intracellular concentration after endocytosis small doses formulation. Most first reports showing activities topical xanthophyll-based nanomedicines against chronic diseases inflammatory bowel disease, psoriasis, atopic dermatitis, dry eye disease emerged between 2020 2023. Here discuss detail preclinical performance, mostly vesicular polymeric nanoparticles, on cellular models vivo. results, although preliminary, auspicious enough speculate upon potential use administration treatment diseases.

Язык: Английский

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Current insights and future perspectives of flavonoids: A promising antihypertensive approach

Phytotherapy Research, Год журнала: 2024, Номер 38(6), С. 3146 - 3168

Опубликована: Апрель 14, 2024

Abstract Hypertension, or high blood pressure (BP), is a complex disease influenced by various risk factors. It characterized persistent elevation of BP levels, typically exceeding 140/90 mmHg. Endothelial dysfunction and reduced nitric oxide (NO) bioavailability play crucial roles in hypertension development. L‐NG‐nitro arginine methyl ester (L‐NAME), an analog L‐arginine, inhibits endothelial NO synthase (eNOS) enzymes, leading to decreased production increased BP. Animal models exposed L‐NAME manifest hypertension, making it useful design for studying the condition. Natural products have gained interest as alternative approaches managing hypertension. Flavonoids, abundant fruits, vegetables, other plant sources, potential cardiovascular benefits, including antihypertensive effects. Flavonoids been extensively studied cell cultures, animal models, and, lesser extent, human trials evaluate their effectiveness against L‐NAME‐induced This comprehensive review summarizes activity specific flavonoids, quercetin, luteolin, rutin, troxerutin, apigenin, chrysin, models. possess antioxidant properties that mitigate oxidative stress, major contributor They enhance function promoting bioavailability, vasodilation, preservation vascular homeostasis. also modulate vasoactive factors involved regulation, such angiotensin‐converting enzyme (ACE) endothelin‐1. Moreover, they exhibit anti‐inflammatory effects, attenuating inflammation‐mediated provides compelling evidence flavonoids Their multifaceted mechanisms action suggest ability target multiple pathways Nonetheless, reviewed studies contribute supporting prevention treatment. In conclusion, represent promising class natural compounds combating serves valuable resource summarizing current knowledge on effects facilitating further investigation guiding development novel therapeutic strategies management.

Язык: Английский

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Gigantol, a promising natural drug for inflammation: a literature review and computational based study

Natural Product Research, Год журнала: 2024, Номер unknown, С. 1 - 17

Опубликована: Апрель 16, 2024

Gigantol, a bibenzyl compound extracted from various medicinal plants, has shown number of biological activities, making it an attractive candidate for potential medical applications. This systematic review aims to shed light on gigantol's promising role in inflammation treatment and its underlying mechanisms. Gigantol exhibits anti-inflammatory properties pre-clinical pharmacological test systems. It effectively reduced the levels pro-inflammatory markers arachidonic acid metabolites through pathways, such as NF-κB, AKT, PI3K, JNK/cPLA2/12-LOX. The in-silico investigations demonstrated that MMP-13 enzyme served most target gigantol with highest binding affinity (docking score = −8.8 kcal/mol). Encouragingly, absorption, distribution, metabolism, excretion, toxicity (ADMET) analysis confirmed compatibility necessary physiochemical, pharmacokinetic, properties, bolstering drug candidate. well-documented could be agent treating near future.

Язык: Английский

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Acute oral toxicity and safety assessment of Morus alba L. (Moraceae) methanol fruit extract in mice

Italian Journal of Food Science, Год журнала: 2024, Номер 36(3), С. 11 - 19

Опубликована: Июль 1, 2024

Mulberry or Morus alba fruits, belonging to the Moraceae family, are well recognized for their distinct taste and high nutritional content. Nevertheless, studies revealing toxic effects of fruits scanty. This study aimed examine adverse methanolic fruit extract (MFME) derived from M. on mice following OECD 425 guidelines. The female Swiss albino were divided into two categories. One group was designated as control (administered vehicle), while other assigned test 2000 mg/kg MFME orally). Subsequently, behavioral changes monitored daily, body weights, relative organ biochemical hematological parameters measured. Additionally, liver, kidney, heart, brain, ovary assessments conducted 14th day detect any signs toxicity. A histopathological investigation anesthetized animals’ vital organs (heart, ovary). study’s findings indicate that oral administration did not result in mortality. no significant seen behavior, food water intake, parameters, investigations, weights. Furthermore, histological analysis revealed notable pathological alterations separated essential treated with MFME. results this is deemed safe up maximum dosage mg/kg.

Язык: Английский

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Approaches, Strategies and Procedures for Identifying Anti-Inflammatory Drug Lead Molecules from Natural Products

Pharmaceuticals, Год журнала: 2024, Номер 17(3), С. 283 - 283

Опубликована: Фев. 22, 2024

Natural products (NPs) have played a vital role in human survival for millennia, particularly their medicinal properties. Many traditional medicine practices continue to utilise crude plants and animal treating various diseases, including inflammation. In contrast, contemporary focuses more on isolating drug-lead compounds from NPs develop new better treatment drugs inflammatory disorders such as bowel diseases. There is an ongoing search drug leads there still no cure many conditions. Various approaches technologies are used discoveries NPs. This review comprehensively anti-inflammatory small molecules describes the key strategies identifying, extracting, fractionating small-molecule leads. also discusses (i) most recently available techniques, artificial intelligence (AI), (ii) machine learning, computational discovery; (iii) provides models cell lines in-vitro in-vivo assessment of potential

Язык: Английский

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The extracts of Carica papaya (Linn.): Phytochemical studies, anti-infective, antioxidant, and cytotoxic properties against cervical carcinoma

South African Journal of Botany, Год журнала: 2025, Номер 177, С. 604 - 616

Опубликована: Янв. 5, 2025

Язык: Английский

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Unveiling the nanoworld of antimicrobial resistance: integrating nature and nanotechnology

Frontiers in Microbiology, Год журнала: 2025, Номер 15

Опубликована: Янв. 9, 2025

A significant global health crisis is predicted to emerge due antimicrobial resistance by 2050, with an estimated 10 million deaths annually. Increasing antibiotic necessitates continuous therapeutic innovation as conventional treatments become increasingly ineffective. The naturally occurring antibacterial, antifungal, and antiviral compounds offer a viable alternative synthetic antibiotics. This review presents bacterial mechanisms, nanocarriers for drug delivery, plant-based nanoformulations, particularly nanoantibiotics (nAbts). Green synthesis of nanoparticles has emerged revolutionary approach, it enhances the effectiveness, specificity, transport encapsulated antimicrobials. In addition minimizing systemic side effects, these can maximize impact delivering antimicrobials directly infection site. Furthermore, combining two or more antibiotics within often exhibits synergistic enhancing effectiveness against drug-resistant bacteria. Antimicrobial agents are routinely obtained from secondary metabolites plants, including essential oils, phenols, polyphenols, alkaloids, others. Integrating antibacterial antibiotics, assisted suitable codelivery, potential solution addressing resistance. increasing their boosting immune system, this approach provides safer effective method tackling future infections.

Язык: Английский

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