Can Plant Extracts Help Prevent Hair Loss or Promote Hair Growth? A Review Comparing Their Therapeutic Efficacies, Phytochemical Components, and Modulatory Targets

Molecules, Год журнала: 2024, Номер 29(10), С. 2288 - 2288

Опубликована: Май 13, 2024

This narrative review aims to examine the therapeutic potential and mechanism of action plant extracts in preventing treating alopecia (baldness). We searched selected research papers on related hair loss, growth, or regrowth, comprehensively compared efficacies, phytochemical components, modulatory targets extracts. These studies showed that various increased survival proliferation dermal papilla cells vitro, enhanced cell growth follicles ex vivo, promoted regrowth animal models vivo. The growth-promoting efficacy several was verified clinical trials. Some phenolic compounds, terpenes terpenoids, sulfur-containing fatty acids were identified as active compounds contained pharmacological effects their associated with promotion survival, proliferation, cycle progression, upregulation factors, such IGF-1, VEGF, HGF, KGF (FGF-7), leading induction extension anagen phase cycle. Those also alleviation oxidative stress, inflammatory response, cellular senescence, apoptosis, downregulation male hormones receptors, entry into telogen Several phytochemicals stimulated signaling pathways mediated by protein kinase B (PKB, called AKT), extracellular signal-regulated kinases (ERK), Wingless Int-1 (WNT), sonic hedgehog (SHH), while suppressing other transforming factor (TGF)-β bone morphogenetic (BMP). Thus, well-selected can have beneficial health. It is proposed discovery targeting aforementioned events will facilitate development new targeted therapies for alopecia.

Язык: Английский

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A Focused Review on Cognitive Improvement by the Genus Salvia L. (Sage)—From Ethnopharmacology to Clinical Evidence

Pharmaceuticals, Год журнала: 2023, Номер 16(2), С. 171 - 171

Опубликована: Янв. 23, 2023

Ethnopharmacology has been an important starting point in medical and pharmaceutical sciences for discovering drug candidates from natural sources. In this regard, the genus Salvia L., commonly known as sage, is one of best-known medicinal aromatic plants Lamiaceae family; it recorded being used memory enhancement European folk medicine. Despite various uses sage medicines, records that have pointed out sage's memory-enhancing properties paved way aforementioned effect to be proven on scientific grounds. There are many preclinical studies excellent reviews referring favorable different species against cognitive dysfunction related Alzheimer's disease (AD). Hence, current review discusses clinical provide evidence dysfunction. Clinical shown some species, i.e., hydroalcoholic extracts essential oils S. officinalis L. lavandulaefolia leaves particular, most prominently effective patients with mild moderate AD, these positive effects young healthy people. However, numbers subjects were small, standardized not part. Our points need longer-term higher administered preparations.

Язык: Английский

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Phytochemistry, Antioxidant Potential, and Antibacterial Activities of Anacyclus pyrethrum: Promising Bioactive Compounds

Horticulturae, Год журнала: 2023, Номер 9(11), С. 1196 - 1196

Опубликована: Ноя. 2, 2023

Secondary metabolites derived from plants have demonstrated significant biological activity and hold both edible medicinal significance. These compounds play a crucial role in the development of pharmaceuticals, particularly context inflammatory disorders chronic diseases associated with oxidative stress. The objective this study was to investigate chemical characterization, antioxidant potential, antibacterial properties aqueous extract Anacyclus pyrethrum (AEAP). To achieve this, we employed various analytical techniques including HPLC–ESI–MS/MS, Fourier transform infrared, X-ray diffraction, scanning electron microscopy, energy-dispersive spectroscopy. AEAP assessed using DPPH (2,2-Diphenyl-1-picrylhydrazyl) reducing power assays, while evaluated against Gram-negative (Escherichia coli Pseudomonas aeruginosa) Gram-positive bacteria (Staphylococcus aureus Enterococcus faecium) broth microdilution assay. Our findings AEAP, as well broad-spectrum bacteria. HPLC analysis identified important bioactive compounds, notably pellitorine 3,4-dihydroxybenzoic acid, known for their properties. Overall, potent activities, suggesting its potential valuable natural source therapeutic applications.

Язык: Английский

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Comparative Phytoprofiling of Achillea millefolium Morphotypes: Assessing Antioxidant Activity, Phenolic and Triterpenic Compounds Variation across Different Plant Parts

Plants, Год журнала: 2024, Номер 13(7), С. 1043 - 1043

Опубликована: Апрель 8, 2024

Achillea millefolium L., commonly known as yarrow, is a versatile and widely distributed plant species with rich history of ethnopharmacological significance. This study aimed to evaluate the comparative differences A. inflorescence morphotypes. The phytochemical profile white pink morphotypes was characterised by complex thirty-four phenolic triterpene compounds. has distinct inflorescence. Phenolic triterpenic profiles were determined, individual compounds quantified in inflorescence, leaf, stem samples two tested. antioxidant activity extracts evaluated free radical scavenging (ABTS) ferric-reducing power (FRAP) assays. Caffeoylquinic acids predominated all parts Chlorogenic acid 3,5-dicaffeoylquinic principal profile. Betulin, betulinic acid, α-amyrin prevailing components predominant flavonoids inflorescences flavones, while leaves, flavonols organ-specific quantitative observed between Leaves consistently displayed highest amounts identified have been testified main source activity. Overall, accumulated higher total amount compared ones. derived from same population reflect specialised metabolites their chemotypes. addresses gaps knowledge, particularly profiling coloured morphotypes, enhancing our understanding chemotypes within species.

Язык: Английский

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Enhancing the antioxidant and anti-inflammatory potentials of mulberry-derived postbiotics through submerged fermentation with B. subtilis H4 and B. amyloliquefaciens LFB112

Food Bioscience, Год журнала: 2024, Номер 60, С. 104252 - 104252

Опубликована: Май 5, 2024

Mulberry-derived postbiotics (MDP) have been scientifically proven to possess beneficial properties for human health, making them potential nutraceuticals. This study aims enhance the antioxidant and anti-inflammatory effect of MDP via submerged fermentation with Bacillus subtilis H4 (H4) amyloliquefaciens LFB112 (LFB112) bacterial strains. Our results demonstrated compelling evidence that combination two strains optimized time (24 hours), inoculum size (8%), substrate (10%) significantly increased 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activities. When compared non-fermented mulberry (NFM), above-optimized conditions showed substantially higher activities such as DPPH, 2,2'-Azino-bis (3-ethylebenzothiazoline-6-sulfonic acid) (ABTS), hydroxyl activities, reducing power capabilities. Moreover, a significant decrease in lipopolysaccharides (LPS)-induced reactive oxygen species (ROS) generated RAW264.7 cells. The antibacterial assays minimum inhibitory concentrations (MICs) bactericidal (MBCs) possesses activity against various pathogenic lowest MIC recorded 32.5 mg/ml S. pullorum CVCC519, while highest observed was 40 P. aeruginosa. MBCs were 55 aureus ATCC43300 CVCC519 respectively. Furthermore, good ant-inflammatory by nitric oxide (NO) concentration (p<0.0001) mRNA expression proinflammatory cytokines response LPS-induced inflammation macrophage cell line. To sum up, our findings indicate novel can be utilized both functional food safe feed additive, possibly benefiting gut metabolic health.

Язык: Английский

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