Cell Reports,
Год журнала:
2022,
Номер
41(3), С. 111451 - 111451
Опубликована: Окт. 1, 2022
Stem
cells
play
central
roles
in
tissue
development,
homeostasis,
and
regeneration.
Decades
of
scientific
research
have
uncovered
processes
stem
cell
decline
organismal
aging,
more
recently,
pioneering
technologies
permit
the
dissection
its
underlying
mechanisms
inform
therapeutic
development
for
aging
aging-associated
disorders.
In
this
review,
we
elucidate
aging-related
features
across
different
somatic
types,
with
a
specific
focus
on
epigenetic
changes,
loss
protein
systemic
influencing
factors,
including
chronic
inflammation,
circadian
rhythm
dysregulation,
metabolic
disorder.
Our
survey
summarizes
biological
implications,
points
to
potential
biomarkers
discusses
cell-based
strategies
promoting
healthy
combating
age-related
diseases.
ACS Omega,
Год журнала:
2020,
Номер
5(20), С. 11849 - 11872
Опубликована: Май 14, 2020
Quercetin
(Que)
and
its
derivatives
are
naturally
occurring
phytochemicals
with
promising
bioactive
effects.
The
antidiabetic,
anti-inflammatory,
antioxidant,
antimicrobial,
anti-Alzheimer's,
antiarthritic,
cardiovascular,
wound-healing
effects
of
Que
have
been
extensively
investigated,
as
well
anticancer
activity
against
different
cancer
cell
lines
has
recently
reported.
found
predominantly
in
the
Western
diet,
people
might
benefit
from
their
protective
effect
just
by
taking
them
via
diets
or
a
food
supplement.
Bioavailability-related
drug-delivery
systems
also
markedly
exploited,
nanoparticles
appear
platform
to
enhance
bioavailability.
present
review
aims
provide
brief
overview
therapeutic
effects,
new
insights,
upcoming
perspectives
Que.
Signal Transduction and Targeted Therapy,
Год журнала:
2022,
Номер
7(1)
Опубликована: Ноя. 7, 2022
Abstract
Aging
is
accompanied
by
the
decline
of
organismal
functions
and
a
series
prominent
hallmarks,
including
genetic
epigenetic
alterations.
These
aging-associated
changes
include
DNA
methylation,
histone
modification,
chromatin
remodeling,
non-coding
RNA
(ncRNA)
regulation,
all
which
participate
in
regulation
aging
process,
hence
contribute
to
aging-related
diseases.
Therefore,
understanding
mechanisms
will
provide
new
avenues
develop
strategies
delay
aging.
Indeed,
interventions
based
on
manipulating
have
led
alleviation
or
extension
lifespan
animal
models.
Small
molecule-based
therapies
reprogramming
that
enable
rejuvenation
been
developed
for
ameliorating
reversing
conditions.
In
addition,
adopting
health-promoting
activities,
such
as
caloric
restriction,
exercise,
calibrating
circadian
rhythm,
has
demonstrated
Furthermore,
various
clinical
trials
intervention
are
ongoing,
providing
more
evidence
safety
efficacy
these
therapies.
Here,
we
review
recent
work
outline
advances
age-associated
A
better
critical
roles
epigenetics
process
lead
prevention
human
therapy
Circulation Research,
Год журнала:
2018,
Номер
123(7), С. 773 - 786
Опубликована: Сен. 13, 2018
Aging
is
associated
with
a
progressive
decline
in
cardiovascular
structure
and
function.
Accumulating
evidence
links
aging
to
epigenetic
alterations
encompassing
complex
interplay
of
DNA
methylation,
histone
posttranslational
modifications,
dynamic
nucleosome
occupancy
governed
by
numerous
factors.
Advances
genomics
technology
have
led
profound
understanding
chromatin
reorganization
both
diseases.
This
review
summarizes
recent
discoveries
mechanisms
involved
diseases
discusses
potential
therapeutic
strategies
retard
conquer
related
through
the
rejuvenation
signatures
young
state.
Cell,
Год журнала:
2023,
Номер
186(2), С. 287 - 304.e26
Опубликована: Янв. 1, 2023
Whether
and
how
certain
transposable
elements
with
viral
origins,
such
as
endogenous
retroviruses
(ERVs)
dormant
in
our
genomes,
can
become
awakened
contribute
to
the
aging
process
is
largely
unknown.
In
human
senescent
cells,
we
found
that
HERVK
(HML-2),
most
recently
integrated
ERVs,
are
unlocked
transcribe
genes
produce
retrovirus-like
particles
(RVLPs).
These
RVLPs
constitute
a
transmissible
message
elicit
senescence
phenotypes
young
which
be
blocked
by
neutralizing
antibodies.
The
activation
of
ERVs
was
also
observed
organs
aged
primates
mice
well
tissues
serum
from
elderly.
Their
repression
alleviates
cellular
tissue
degeneration
and,
some
extent,
organismal
aging.
findings
indicate
resurrection
hallmark
driving
force
Nature Metabolism,
Год журнала:
2021,
Номер
3(12), С. 1706 - 1726
Опубликована: Дек. 6, 2021
Abstract
Ageing-associated
functional
decline
of
organs
and
increased
risk
for
age-related
chronic
pathologies
is
driven
in
part
by
the
accumulation
senescent
cells,
which
develop
senescence-associated
secretory
phenotype
(SASP).
Here
we
show
that
procyanidin
C1
(PCC1),
a
polyphenolic
component
grape
seed
extract
(GSE),
increases
healthspan
lifespan
mice
through
its
action
on
cells.
By
screening
library
natural
products,
find
GSE,
PCC1
as
one
active
components,
have
specific
effects
At
low
concentrations,
appears
to
inhibit
SASP
formation,
whereas
it
selectively
kills
cells
at
higher
possibly
promoting
production
reactive
oxygen
species
mitochondrial
dysfunction.
In
rodent
models,
depletes
treatment-damaged
tumour
microenvironment
enhances
therapeutic
efficacy
when
co-administered
with
chemotherapy.
Intermittent
administration
either
irradiated,
cell-implanted
or
naturally
aged
old
alleviates
physical
dysfunction
prolongs
survival.
We
identify
senotherapeutic
agent
vivo
activity
high
potential
further
development
clinical
intervention
delay,
alleviate
prevent
pathologies.
