Cell Reports,
Год журнала:
2022,
Номер
41(3), С. 111451 - 111451
Опубликована: Окт. 1, 2022
Stem
cells
play
central
roles
in
tissue
development,
homeostasis,
and
regeneration.
Decades
of
scientific
research
have
uncovered
processes
stem
cell
decline
organismal
aging,
more
recently,
pioneering
technologies
permit
the
dissection
its
underlying
mechanisms
inform
therapeutic
development
for
aging
aging-associated
disorders.
In
this
review,
we
elucidate
aging-related
features
across
different
somatic
types,
with
a
specific
focus
on
epigenetic
changes,
loss
protein
systemic
influencing
factors,
including
chronic
inflammation,
circadian
rhythm
dysregulation,
metabolic
disorder.
Our
survey
summarizes
biological
implications,
points
to
potential
biomarkers
discusses
cell-based
strategies
promoting
healthy
combating
age-related
diseases.
Redox Biology,
Год журнала:
2019,
Номер
28, С. 101337 - 101337
Опубликована: Окт. 4, 2019
Cellular
senescence
may
contribute
to
aging
and
age-related
diseases
senolytic
drugs
that
selectively
kill
senescent
cells
delay
promote
healthspan.
More
recently,
several
categories
of
senolytics
have
been
established,
namely
HSP90
inhibitors,
Bcl-2
family
inhibitors
natural
compounds
such
as
quercetin
fisetin.
However,
senostatic
potential
nanoparticles
surface-modified
has
never
addressed.
In
the
present
study,
surface
functionalized
Fe3O4
(MNPQ)
were
synthesized
their
activity
was
evaluated
during
oxidative
stress-induced
in
human
fibroblasts
vitro.
MNPQ
promoted
AMPK
accompanied
by
non-apoptotic
cell
death
decreased
number
(senolytic
action)
suppression
senescence-associated
proinflammatory
response
(decreased
levels
secreted
IL-8
IFN-β,
action).
summary,
we
shown
for
first
time
be
considered
promising
candidates
senolytic-
senostatic-based
anti-aging
therapies.
World Journal of Stem Cells,
Год журнала:
2019,
Номер
11(6), С. 337 - 346
Опубликована: Июнь 26, 2019
Organs
whose
source
is
the
mesoderm
lineage
contain
a
subpopulation
of
stem
cells
that
are
able
to
differentiate
among
mesodermal
derivatives
(chondrocytes,
osteocytes,
adipocytes).
This
adult
cells,
called
"mesenchymal
cells"
or
stromal
(MSCs)",
contributes
directly
homeostatic
maintenance
their
organs;
hence,
senescence
could
be
very
deleterious
for
human
bodily
functions.
MSCs
easily
isolated
and
amenable
expansion
Cell Death and Disease,
Год журнала:
2020,
Номер
11(11)
Опубликована: Ноя. 11, 2020
Abstract
Maternal
fertility
declines
irreversibly
with
aging,
and
advanced
maternal
age
is
mostly
related
to
impaired
oocyte
quality.
The
flavonol
compound
quercetin
considered
be
an
anti-aging
agent
due
its
cytoprotective
actions
as
antioxidant.
However,
role
mechanisms
on
aged
oocytes
are
unclear.
In
this
study,
the
promotes
in
vitro
maturation
(IVM)
early
embryonic
development
of
from
mice.
It
extended
these
findings
human
oocytes,
showing
that
IVM
rate
by
19.6%
increases
blastocyst
formation
15.5%
compared
untreated
controls.
overall
quality
mice
improved
treatment,
assessed
spindle/chromosome
morphology
cortical
granule
distribution.
Mitochondria
primary
endogenous
source
age-related
oxidative
stress,
RNA-seq
analysis
quercetin-treated
reveals
molecular
insights
including
scavenged
mitochondrial-ROS,
reduced
apoptosis,
autophagy.
Further,
study
demonstrates
reduces
ROS
via
SIRT3-mediated
acetylation
SOD2’s
K68
residue.
Thus,
beyond
demonstrating
confers
beneficial
mitochondria-related
impacts
illustrates
a
potential
strategy
prevent
or
delay
aging
improve
success
rates
assisted
reproductive
technologies
(ART).
Cell Reports,
Год журнала:
2022,
Номер
41(3), С. 111451 - 111451
Опубликована: Окт. 1, 2022
Stem
cells
play
central
roles
in
tissue
development,
homeostasis,
and
regeneration.
Decades
of
scientific
research
have
uncovered
processes
stem
cell
decline
organismal
aging,
more
recently,
pioneering
technologies
permit
the
dissection
its
underlying
mechanisms
inform
therapeutic
development
for
aging
aging-associated
disorders.
In
this
review,
we
elucidate
aging-related
features
across
different
somatic
types,
with
a
specific
focus
on
epigenetic
changes,
loss
protein
systemic
influencing
factors,
including
chronic
inflammation,
circadian
rhythm
dysregulation,
metabolic
disorder.
Our
survey
summarizes
biological
implications,
points
to
potential
biomarkers
discusses
cell-based
strategies
promoting
healthy
combating
age-related
diseases.
