Abstract
High
cobalt
(Co)
levels
in
tumors
are
associated
with
good
clinical
prognosis.
An
anticancer
regimen
that
increases
intratumoral
Co
through
targeted
nanomaterial
delivery
is
proposed
this
study.
Bovine
serum
albumin
and
dichloride
applied
to
prepare
cobaltous
oxide
nanodots
using
a
facile
biomineralization
strategy.
After
iRGD
peptide
conjugation,
the
loaded
into
dendritic
mesoporous
silica
nanoparticles,
generating
biocompatible
product
iCoDMSN.
This
nanocomposite
accumulates
after
intravenous
injection
by
deep
tissue
penetration
can
be
used
for
photoacoustic
imaging.
Proteomics
research
molecular
biology
experiments
reveal
iCoDMSN
potent
ferroptosis
inducer
cancer
cells.
Mechanistically,
iCoDMSNs
upregulate
heme
oxygenase
1
(HMOX1),
which
transferrin
receptors
reduces
solute
carrier
family
40
member
(SLC40A1),
resulting
Fe
2+
accumulation
initiation.
Furthermore,
upregulated
nuclear
factor
erythroid
2‐related
2
(NRF2),
arising
from
reduction
Kelch‐like
ECH‐associated
protein
(KEAP1)
expression,
responsible
HMOX1
enhancement
treatment.
Owing
intensified
ferroptosis,
acts
as
an
efficient
radiotherapy
enhancer
eliminate
cells
vitro
vivo.
study
demonstrates
versatile
Co‐based
primes
expanding
labile
iron
pool
cells,
providing
promising
tumor
sensitizer.
Bioactive Materials,
Год журнала:
2023,
Номер
32, С. 66 - 97
Опубликована: Сен. 29, 2023
Ferroptosis
offers
a
novel
method
for
overcoming
therapeutic
resistance
of
cancers
to
conventional
cancer
treatment
regimens.
Its
effective
use
as
therapy
requires
precisely
targeted
approach,
which
can
be
facilitated
by
using
nanoparticles
and
nanomedicine,
their
enhance
ferroptosis
is
indeed
growing
area
research.
While
few
review
papers
have
been
published
on
iron-dependent
mechanism
inducers
that
partly
covers
nanoparticles,
there
need
comprehensive
focusing
the
design
magnetic
typically
supply
iron
ions
promote
simultaneously
enable
nanomedicine.
Furthermore,
locally
induce
combinational
with
diagnostic
resonance
imaging
(MRI).
The
remotely
controllable
nanocarriers
offer
highly
localized
image-guided
Here,
recent
developments
in
magnetically
manipulable
nanomedicine
medical
are
summarized.
This
also
highlights
advantages
current
state-of-the-art
Finally,
image
guided
apoptosis-based
enables
synergistic
tumor
discussed
clinical
translations.
ACS Nano,
Год журнала:
2023,
Номер
17(17), С. 16432 - 16447
Опубликована: Авг. 30, 2023
Radiotherapy
is
a
mainstay
of
glioblastoma
(GBM)
treatment;
however,
the
development
therapeutic
resistance
has
hampered
efficacy
radiotherapy,
suggesting
that
additional
treatment
strategies
are
needed.
Here,
an
in
vivo
loss-of-function
genome-wide
CRISPR
screen
was
carried
out
orthotopic
tumors
mice
subjected
to
radiation
identify
synthetic
lethal
genes
associated
with
radiotherapy.
Using
functional
screening
and
transcriptome
analyses,
glutathione
synthetase
(GSS)
found
be
potential
regulator
radioresistance
through
ferroptosis.
High
GSS
levels
were
closely
related
poor
prognosis
relapse
patients
glioma.
Mechanistic
studies
demonstrated
suppression
radiotherapy-induced
ferroptosis
glioma
cells.
The
depletion
resulted
disruption
(GSH)
synthesis,
thereby
causing
inactivation
GPX4
iron
accumulation,
thus
enhancing
induction
upon
radiotherapy
treatment.
Moreover,
overcome
obstacles
broad
translation
editing,
we
report
previously
unidentified
genome
editing
delivery
system,
which
Cas9
protein/sgRNA
complex
loaded
into
Angiopep-2
(Ang)
trans-activator
transcription
(TAT)
peptide
dual-modified
extracellular
vesicle
(EV),
not
only
targeted
blood–brain
barrier
(BBB)
GBM
but
also
permeated
BBB
penetrated
tumor.
Our
encapsulating
EVs
showed
encouraging
signs
tissue
targeting,
high
gene
efficiency
(up
67.2%)
negligible
off-target
editing.
These
results
demonstrate
combination
unbiased
genetic
screens,
CRISPR-Cas9-based
therapy
feasible
for
identifying
and,
by
extension,
targets.
Abstract
High
cobalt
(Co)
levels
in
tumors
are
associated
with
good
clinical
prognosis.
An
anticancer
regimen
that
increases
intratumoral
Co
through
targeted
nanomaterial
delivery
is
proposed
this
study.
Bovine
serum
albumin
and
dichloride
applied
to
prepare
cobaltous
oxide
nanodots
using
a
facile
biomineralization
strategy.
After
iRGD
peptide
conjugation,
the
loaded
into
dendritic
mesoporous
silica
nanoparticles,
generating
biocompatible
product
iCoDMSN.
This
nanocomposite
accumulates
after
intravenous
injection
by
deep
tissue
penetration
can
be
used
for
photoacoustic
imaging.
Proteomics
research
molecular
biology
experiments
reveal
iCoDMSN
potent
ferroptosis
inducer
cancer
cells.
Mechanistically,
iCoDMSNs
upregulate
heme
oxygenase
1
(HMOX1),
which
transferrin
receptors
reduces
solute
carrier
family
40
member
(SLC40A1),
resulting
Fe
2+
accumulation
initiation.
Furthermore,
upregulated
nuclear
factor
erythroid
2‐related
2
(NRF2),
arising
from
reduction
Kelch‐like
ECH‐associated
protein
(KEAP1)
expression,
responsible
HMOX1
enhancement
treatment.
Owing
intensified
ferroptosis,
acts
as
an
efficient
radiotherapy
enhancer
eliminate
cells
vitro
vivo.
study
demonstrates
versatile
Co‐based
primes
expanding
labile
iron
pool
cells,
providing
promising
tumor
sensitizer.