Clustered Cobalt Nanodots Initiate Ferroptosis by Upregulating Heme Oxygenase 1 for Radiotherapy Sensitization DOI

Jianqi Zhao,

Yin Chen,

Tainong Xiong

и другие.

Small, Год журнала: 2023, Номер 19(10)

Опубликована: Янв. 10, 2023

Abstract High cobalt (Co) levels in tumors are associated with good clinical prognosis. An anticancer regimen that increases intratumoral Co through targeted nanomaterial delivery is proposed this study. Bovine serum albumin and dichloride applied to prepare cobaltous oxide nanodots using a facile biomineralization strategy. After iRGD peptide conjugation, the loaded into dendritic mesoporous silica nanoparticles, generating biocompatible product iCoDMSN. This nanocomposite accumulates after intravenous injection by deep tissue penetration can be used for photoacoustic imaging. Proteomics research molecular biology experiments reveal iCoDMSN potent ferroptosis inducer cancer cells. Mechanistically, iCoDMSNs upregulate heme oxygenase 1 (HMOX1), which transferrin receptors reduces solute carrier family 40 member (SLC40A1), resulting Fe 2+ accumulation initiation. Furthermore, upregulated nuclear factor erythroid 2‐related 2 (NRF2), arising from reduction Kelch‐like ECH‐associated protein (KEAP1) expression, responsible HMOX1 enhancement treatment. Owing intensified ferroptosis, acts as an efficient radiotherapy enhancer eliminate cells vitro vivo. study demonstrates versatile Co‐based primes expanding labile iron pool cells, providing promising tumor sensitizer.

Язык: Английский

Magnetic nanoparticles for ferroptosis cancer therapy with diagnostic imaging DOI Creative Commons
Min Jun Ko, Sunhong Min, Hyunsik Hong

и другие.

Bioactive Materials, Год журнала: 2023, Номер 32, С. 66 - 97

Опубликована: Сен. 29, 2023

Ferroptosis offers a novel method for overcoming therapeutic resistance of cancers to conventional cancer treatment regimens. Its effective use as therapy requires precisely targeted approach, which can be facilitated by using nanoparticles and nanomedicine, their enhance ferroptosis is indeed growing area research. While few review papers have been published on iron-dependent mechanism inducers that partly covers nanoparticles, there need comprehensive focusing the design magnetic typically supply iron ions promote simultaneously enable nanomedicine. Furthermore, locally induce combinational with diagnostic resonance imaging (MRI). The remotely controllable nanocarriers offer highly localized image-guided Here, recent developments in magnetically manipulable nanomedicine medical are summarized. This also highlights advantages current state-of-the-art Finally, image guided apoptosis-based enables synergistic tumor discussed clinical translations.

Язык: Английский

Процитировано

57

Zooming in and out of ferroptosis in human disease DOI
Xue Wang, Ye Zhou, Junxia Min

и другие.

Frontiers of Medicine, Год журнала: 2023, Номер 17(2), С. 173 - 206

Опубликована: Апрель 1, 2023

Язык: Английский

Процитировано

55

Engineered Extracellular Vesicle-Delivered CRISPR/Cas9 for Radiotherapy Sensitization of Glioblastoma DOI Creative Commons
Xiao Liu,

Zhengcong Cao,

Weizhong Wang

и другие.

ACS Nano, Год журнала: 2023, Номер 17(17), С. 16432 - 16447

Опубликована: Авг. 30, 2023

Radiotherapy is a mainstay of glioblastoma (GBM) treatment; however, the development therapeutic resistance has hampered efficacy radiotherapy, suggesting that additional treatment strategies are needed. Here, an in vivo loss-of-function genome-wide CRISPR screen was carried out orthotopic tumors mice subjected to radiation identify synthetic lethal genes associated with radiotherapy. Using functional screening and transcriptome analyses, glutathione synthetase (GSS) found be potential regulator radioresistance through ferroptosis. High GSS levels were closely related poor prognosis relapse patients glioma. Mechanistic studies demonstrated suppression radiotherapy-induced ferroptosis glioma cells. The depletion resulted disruption (GSH) synthesis, thereby causing inactivation GPX4 iron accumulation, thus enhancing induction upon radiotherapy treatment. Moreover, overcome obstacles broad translation editing, we report previously unidentified genome editing delivery system, which Cas9 protein/sgRNA complex loaded into Angiopep-2 (Ang) trans-activator transcription (TAT) peptide dual-modified extracellular vesicle (EV), not only targeted blood–brain barrier (BBB) GBM but also permeated BBB penetrated tumor. Our encapsulating EVs showed encouraging signs tissue targeting, high gene efficiency (up 67.2%) negligible off-target editing. These results demonstrate combination unbiased genetic screens, CRISPR-Cas9-based therapy feasible for identifying and, by extension, targets.

Язык: Английский

Процитировано

55

Ferroptosis: Mechanisms and role in diabetes mellitus and its complications DOI
Pan Liu, Zhengdong Zhang, Yichen Cai

и другие.

Ageing Research Reviews, Год журнала: 2024, Номер 94, С. 102201 - 102201

Опубликована: Янв. 19, 2024

Язык: Английский

Процитировано

49

Clustered Cobalt Nanodots Initiate Ferroptosis by Upregulating Heme Oxygenase 1 for Radiotherapy Sensitization DOI

Jianqi Zhao,

Yin Chen,

Tainong Xiong

и другие.

Small, Год журнала: 2023, Номер 19(10)

Опубликована: Янв. 10, 2023

Abstract High cobalt (Co) levels in tumors are associated with good clinical prognosis. An anticancer regimen that increases intratumoral Co through targeted nanomaterial delivery is proposed this study. Bovine serum albumin and dichloride applied to prepare cobaltous oxide nanodots using a facile biomineralization strategy. After iRGD peptide conjugation, the loaded into dendritic mesoporous silica nanoparticles, generating biocompatible product iCoDMSN. This nanocomposite accumulates after intravenous injection by deep tissue penetration can be used for photoacoustic imaging. Proteomics research molecular biology experiments reveal iCoDMSN potent ferroptosis inducer cancer cells. Mechanistically, iCoDMSNs upregulate heme oxygenase 1 (HMOX1), which transferrin receptors reduces solute carrier family 40 member (SLC40A1), resulting Fe 2+ accumulation initiation. Furthermore, upregulated nuclear factor erythroid 2‐related 2 (NRF2), arising from reduction Kelch‐like ECH‐associated protein (KEAP1) expression, responsible HMOX1 enhancement treatment. Owing intensified ferroptosis, acts as an efficient radiotherapy enhancer eliminate cells vitro vivo. study demonstrates versatile Co‐based primes expanding labile iron pool cells, providing promising tumor sensitizer.

Язык: Английский

Процитировано

45