Опубликована: Май 8, 2024
Язык: Английский
Biosensors, Год журнала: 2025, Номер 15(5), С. 285 - 285
Опубликована: Апрель 30, 2025
This study introduces a cutting-edge, aptamer-based, planar electric, double-layer field-effect transistor (FET) system that offers both high sensitivity and specificity for the detection of troponin I (TnI). The proposed sensing platform leverages signal amplification capabilities FETs alongside unique attributes electric design to address limitations inherent in traditional ion-sensitive detectors, which are impacted by Debye length effects. By integrating TnI-specific aptamers, markedly enhances molecular recognition transduction efficiency, achieving an impressive limit 0.0001467 decade. Furthermore, sensor demonstrates strong exponential linear response across clinically relevant concentration range 1 ng/mL 100 ng/mL. innovative approach underscores potential FET systems advance biomarker technologies medical diagnostics point-of-care applications.
Язык: Английский
Процитировано
0
Advanced NanoBiomed Research, Год журнала: 2024, Номер 4(6)
Опубликована: Март 31, 2024
Hydrogels have emerged as a focal point of research in the biomedical field due to their applications tissue repair. However, majority hydrogels lack capability release oxygen, constraining therapeutic outcomes environments with hypoxic tissues. In recent years, oxygen‐releasing garnered extensive attention engineering, owing ability modulate oxygen and meet diverse oxygenation requirements various These can enhance repair efficiency promote regeneration environments. The design primarily involves utilization sources, such algae, perfluorocarbons, peroxides, achieve optimal oxygenation. This review provides comprehensive summary fabrication strategies hydrogels, discusses deeply into underlying mechanisms, myriad along prospective challenges.
Язык: Английский
Процитировано
2
Nanomedicine, Год журнала: 2024, Номер 19(16), С. 1487 - 1506
Опубликована: Июль 2, 2024
Mortality from cardiovascular disease (CVD) accounts for over 30% of all deaths globally, necessitating reliable diagnostic tools. Prompt identification and precise diagnosis are critical effective personalized treatment. Nanotechnology offers promising applications in diagnostics, biosensing drug delivery prevalent diseases. Its integration into care enhances accuracy, enabling early intervention tailored treatment plans. By leveraging nanoscale innovations, healthcare professionals can address the complexities CVD progression customize interventions based on individual patient needs. Ongoing advancements nanotechnology continue to shape landscape medicine, offering potential improved outcomes reduced mortality rates these pervasive
Язык: Английский
Процитировано
2
The Analyst, Год журнала: 2024, Номер 150(2), С. 362 - 370
Опубликована: Дек. 9, 2024
Acute myocardial infarction (AMI) accounts for a significant proportion of global fatalities, and early detection is crucial improving patient outcomes.
Язык: Английский
Процитировано
2
Journal of King Saud University - Science, Год журнала: 2024, Номер 36(7), С. 103236 - 103236
Опубликована: Май 3, 2024
Myocardial infarction (MI) is a serious heart ailment that requires cutting-edge remedies for effective treatment. This study examines the possible cardioprotective effects of hydroalcoholic extract from Satureja hortensis L. (HASH) in rats with isoproterenol (ISO) induced myocardial infarction. The were pretreated orally low (200 mg/kg), high dose (400 and metoprolol (10 their respective groups 30 days, followed by two subcutaneous doses (ISO). Blood was obtained to measure biochemicals such as creatine kinase-MB (CK-MB), Troponin I, Alanine transaminase (ALT), Aspartate (AST), lactate dehydrogenase (LDH), an electrocardiogram (ECG) rat recorded after experiment. integrity examined histopathologically, malondialdehyde (MDA) levels antioxidant enzyme concentrations assessed using tissue homogenate. Rats caused ISO displayed significantly (P < 0.001) augmented CK-MB, LDH, AST, ALT aberrant ECG patterns, alteration cardiac mass well enhaced oxidative stress marker levels. Besides, biochemical results validated myocardium histology. Pre-treatment animals mg/kg) HASH or standard agent (metoprolol) prevented ISO-induced alterations above parameters significant 0.01) level metabolic derangements functional alterations. Our research suggests pre-treatment has action can prevent toxicity ISO. Therefore, might be promising therapeutic plant further investigated potential properties.
Язык: Английский
Процитировано
1
Archives of Pharmacy Practice, Год журнала: 2024, Номер 15(1), С. 68 - 83
Опубликована: Янв. 1, 2024
Proteomics is a scientific field dedicated to the investigation of protein structure function and interactions within living organisms.The review paper explores facets proteomics its diverse applications across various research domains.The sheds light on crucial role proteome an organism, influenced by factors such as physiological condition surroundings.Nutritional proteomics, referred neuroproteomics, employs proteomic methods delve into between proteins bioactive components found in food.Nutriproteomics nutrigenomics, enable comprehensive investigations how nutrients interact impact human genome.The highlights exploration alterations associated with diseases emphasizes nutritional disease treatment.It accentuates potential identifying biomarkers for unraveling intricate protein-level conditions, infectious diseases, cancer, cardiovascular disorders, neurodegenerative illnesses.The connection technologies drug discovery also discussed.The further underscores integration different 'omics' disciplines offers holistic understanding complex biological systems.Ultimately, concludes emphasizing promising advancing both healthcare.
Язык: Английский
Процитировано
1
Electroanalysis, Год журнала: 2024, Номер 36(6)
Опубликована: Фев. 8, 2024
Abstract A direct electron tunneling of myoglobin (cardiac biomarker) onto a magnesium oxide templated carbon electrode surface (MgOC) was observed. The porous material employed in this work possesses 3D macropores structure. Herein, the presence curvature‐like structure provides favorable environment for anchoring protein myoglobin, which facilitates transfer by encapsulated within electroactive and improves mass inside carbon. at MgOC demonstrated usefulness as an effective platform studying redox properties various proteins biomolecules that are clinical relevance. proposed strategy is distinct from other known electrochemical strategies involve denaturant to partially open up myoglobin‘s redox‐active center, thereby not detected its native state. Our results also indicated concentration‐dependent irreversible heme center surface. Further, detection rapid, analysis can be completed few minutes than existing approaches may take days week results. exhibited excellent stability towards myoglobin.
Язык: Английский
Процитировано
1
Transplant Immunology, Год журнала: 2024, Номер 85, С. 102070 - 102070
Опубликована: Июнь 4, 2024
Язык: Английский
Процитировано
1
Elsevier eBooks, Год журнала: 2024, Номер unknown, С. 387 - 399
Опубликована: Ноя. 1, 2024
Процитировано
1
Langmuir, Год журнала: 2024, Номер 40(47), С. 25051 - 25060
Опубликована: Ноя. 12, 2024
The fast, and highly sensitive estimation of cardiac troponin T (cTnT) is crucial for the early identification acute myocardial infarction (AMI). electrochemical immunoassay-based (EIB) sensors are promising this purpose, as they offer precise measurements can be directly assessed in intricate matrices, including blood. To increase sensitivity, EIB use nanomaterials or amplification processes, which laborious to develop. With this, we develop an immunosensor detection (cTnT). sensing platform composed functionalized triangular carbon quantum dots stabilized gold nanoparticles integrated with boron nitride nanosheets (caf-TCQDs@AuNPs on HO-BNNS). Ferrocene carboxylic acid (Fc-COOH) serves signal label. composite was developed examined using several techniques such X-ray diffraction (XRD), photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), cyclic voltammetry, chronocoulometry. caf-TCQDs@AuNPs supported HO-BNNS, have a large surface area excellent electrical conductivity, serve effective immobilization anti-cTnT monoclonal antibodies via carbodiimide coupling. Fc-COOH, functioning label through oxidation process, HO-BNNS establish cTnT. demonstrated performance determination cTnT under optimal conditions, exhibiting linearity range spanning from 0.0001 100 ng mL
Язык: Английский
Процитировано
1