Functionalized Triangular Carbon Quantum Dot Stabilized Gold Nanoparticles Decorated Boron Nitride Nanosheets Interfaced for Electrochemical Detection of Cardiac Troponin T DOI
So Eun Kim, Jae Chol Yoon, Alagan Muthurasu

et al.

Langmuir, Journal Year: 2024, Volume and Issue: 40(47), P. 25051 - 25060

Published: Nov. 12, 2024

The fast, and highly sensitive estimation of cardiac troponin T (cTnT) is crucial for the early identification acute myocardial infarction (AMI). electrochemical immunoassay-based (EIB) sensors are promising this purpose, as they offer precise measurements can be directly assessed in intricate matrices, including blood. To increase sensitivity, EIB use nanomaterials or amplification processes, which laborious to develop. With this, we develop an immunosensor detection (cTnT). sensing platform composed functionalized triangular carbon quantum dots stabilized gold nanoparticles integrated with boron nitride nanosheets (caf-TCQDs@AuNPs on HO-BNNS). Ferrocene carboxylic acid (Fc-COOH) serves signal label. composite was developed examined using several techniques such X-ray diffraction (XRD), photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), cyclic voltammetry, chronocoulometry. caf-TCQDs@AuNPs supported HO-BNNS, have a large surface area excellent electrical conductivity, serve effective immobilization anti-cTnT monoclonal antibodies via carbodiimide coupling. Fc-COOH, functioning label through oxidation process, HO-BNNS establish cTnT. demonstrated performance determination cTnT under optimal conditions, exhibiting linearity range spanning from 0.0001 100 ng mL

Language: Английский

Advances in nanotechnological approaches for the detection of early markers associated with severe cardiac ailments DOI
Jie Wang, Haifeng Zhang,

Weiping Wan

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: 19(16), P. 1487 - 1506

Published: July 2, 2024

Mortality from cardiovascular disease (CVD) accounts for over 30% of all deaths globally, necessitating reliable diagnostic tools. Prompt identification and precise diagnosis are critical effective personalized treatment. Nanotechnology offers promising applications in diagnostics, biosensing drug delivery prevalent diseases. Its integration into care enhances accuracy, enabling early intervention tailored treatment plans. By leveraging nanoscale innovations, healthcare professionals can address the complexities CVD progression customize interventions based on individual patient needs. Ongoing advancements nanotechnology continue to shape landscape medicine, offering potential improved outcomes reduced mortality rates these pervasive

Language: Английский

Citations

2
Low Background Electrochemical Sensor based on HCR Towards Acute Myocardial Infarction-specific miRNA Detection DOI
Yi Yan, Ziqi Liu,

Tingxiu Yan

et al.

The Analyst, Journal Year: 2024, Volume and Issue: 150(2), P. 362 - 370

Published: Dec. 9, 2024

Acute myocardial infarction (AMI) accounts for a significant proportion of global fatalities, and early detection is crucial improving patient outcomes.

Language: Английский

Citations

2
Nutritional Proteomics: A Key to Unlocking Optimal Human Health DOI Creative Commons

Hala Salim Sonbol

Archives of Pharmacy Practice, Journal Year: 2024, Volume and Issue: 15(1), P. 68 - 83

Published: Jan. 1, 2024

Proteomics is a scientific field dedicated to the investigation of protein structure function and interactions within living organisms.The review paper explores facets proteomics its diverse applications across various research domains.The sheds light on crucial role proteome an organism, influenced by factors such as physiological condition surroundings.Nutritional proteomics, referred neuroproteomics, employs proteomic methods delve into between proteins bioactive components found in food.Nutriproteomics nutrigenomics, enable comprehensive investigations how nutrients interact impact human genome.The highlights exploration alterations associated with diseases emphasizes nutritional disease treatment.It accentuates potential identifying biomarkers for unraveling intricate protein-level conditions, infectious diseases, cancer, cardiovascular disorders, neurodegenerative illnesses.The connection technologies drug discovery also discussed.The further underscores integration different 'omics' disciplines offers holistic understanding complex biological systems.Ultimately, concludes emphasizing promising advancing both healthcare.

Language: Английский

Citations

1
Porous carbon‐based electrochemical platform for direct electron transfer in myoglobin DOI
Md Motaher Hossain,

Jannatul Morshed,

Akira Nomoto

et al.

Electroanalysis, Journal Year: 2024, Volume and Issue: 36(6)

Published: Feb. 8, 2024

Abstract A direct electron tunneling of myoglobin (cardiac biomarker) onto a magnesium oxide templated carbon electrode surface (MgOC) was observed. The porous material employed in this work possesses 3D macropores structure. Herein, the presence curvature‐like structure provides favorable environment for anchoring protein myoglobin, which facilitates transfer by encapsulated within electroactive and improves mass inside carbon. at MgOC demonstrated usefulness as an effective platform studying redox properties various proteins biomolecules that are clinical relevance. proposed strategy is distinct from other known electrochemical strategies involve denaturant to partially open up myoglobin‘s redox‐active center, thereby not detected its native state. Our results also indicated concentration‐dependent irreversible heme center surface. Further, detection rapid, analysis can be completed few minutes than existing approaches may take days week results. exhibited excellent stability towards myoglobin.

Language: Английский

Citations

1
Oxygen‐Releasing Hydrogels for Tissue Regeneration DOI Creative Commons

Shengxi Jiang,

Yujia Zheng,

Hao Xia

et al.

Advanced NanoBiomed Research, Journal Year: 2024, Volume and Issue: 4(6)

Published: March 31, 2024

Hydrogels have emerged as a focal point of research in the biomedical field due to their applications tissue repair. However, majority hydrogels lack capability release oxygen, constraining therapeutic outcomes environments with hypoxic tissues. In recent years, oxygen‐releasing garnered extensive attention engineering, owing ability modulate oxygen and meet diverse oxygenation requirements various These can enhance repair efficiency promote regeneration environments. The design primarily involves utilization sources, such algae, perfluorocarbons, peroxides, achieve optimal oxygenation. This review provides comprehensive summary fabrication strategies hydrogels, discusses deeply into underlying mechanisms, myriad along prospective challenges.

Language: Английский

Citations

1
Thrombomodulin as a potential diagnostic marker of acute myocardial infarction and correlation with immune infiltration: Comprehensive analysis based on multiple machine learning DOI
Guoqing Liu, Lixia Huang,

Xiangwen Lv

et al.

Transplant Immunology, Journal Year: 2024, Volume and Issue: 85, P. 102070 - 102070

Published: June 4, 2024

Language: Английский

Citations

1
Photoelectrochemical Sensing Strategies for Cardiovascular Biomarkers: A Review DOI Creative Commons
Xiaoping Zhang, Yaya Qin

International Journal of Electrochemical Science, Journal Year: 2024, Volume and Issue: unknown, P. 100906 - 100906

Published: Nov. 1, 2024

Language: Английский

Citations

1
Distinction of Male and Female Trees of Ginkgo biloba Using LAMP DOI Open Access

Jin-Pyo Lee,

Joo-Ah Woo,

Woo‐Ri Shin

et al.

Molecular Biotechnology, Journal Year: 2023, Volume and Issue: 65(10), P. 1693 - 1703

Published: Feb. 6, 2023

Language: Английский

Citations

3
Antitumor activity of bengamide ii in a panel of human and murine tumor cell lines: In vitro and in vivo determination of effectiveness against lung cancer DOI Open Access
Alba Ortigosa‐Palomo, Cristina Porras-Alcalá, Francisco Quiñonero

et al.

Biomedicine & Pharmacotherapy, Journal Year: 2023, Volume and Issue: 168, P. 115789 - 115789

Published: Nov. 2, 2023

Lung cancer is the most commonly diagnosed and one that causes deaths worldwide, so there a need for therapies improve survival rates. Products derived from marine organisms are source of novel potent antitumor compounds, but they present great obstacle their obtaining natural environment problems associated with synthesis biological effects chemical analogues. In this work, Bengamide analogue (Bengamide II) was chemically synthesized in vitro vivo studies were performed to determine its activity mechanisms action. It shown have antiproliferative lung lines 2D 3D models. addition, II-treated cells showed G2/M G0/G1 cell cycle arrest, together decrease proliferation marker Ki67. As mechanism action, treatment increased LC3-II expression production acidic vesicles signaling autophagy. II caspase-3 activation DNA fragmentation related apoptosis. Furthermore, reduction VEGFA expression, angiogenesis, also observed. markedly reduced tumor volume metastases increasing survival. Additionally, it revealed no systemic toxicity models at therapeutic doses used, which essential future clinical use. Taken together, bengamide II, promising drug showing relevant significant safety.

Language: Английский

Citations

3
Evaluation of the cardioprotective activity of summer savory (Satureja hortensis L.) extract in experimental rats with Isoproterenol-induced myocardial infarction DOI Creative Commons
A. Muthukumar, Swati Mittal,

Tsering Choezom

et al.

Journal of King Saud University - Science, Journal Year: 2024, Volume and Issue: 36(7), P. 103236 - 103236

Published: May 3, 2024

Myocardial infarction (MI) is a serious heart ailment that requires cutting-edge remedies for effective treatment. This study examines the possible cardioprotective effects of hydroalcoholic extract from Satureja hortensis L. (HASH) in rats with isoproterenol (ISO) induced myocardial infarction. The were pretreated orally low (200 mg/kg), high dose (400 and metoprolol (10 their respective groups 30 days, followed by two subcutaneous doses (ISO). Blood was obtained to measure biochemicals such as creatine kinase-MB (CK-MB), Troponin I, Alanine transaminase (ALT), Aspartate (AST), lactate dehydrogenase (LDH), an electrocardiogram (ECG) rat recorded after experiment. integrity examined histopathologically, malondialdehyde (MDA) levels antioxidant enzyme concentrations assessed using tissue homogenate. Rats caused ISO displayed significantly (P < 0.001) augmented CK-MB, LDH, AST, ALT aberrant ECG patterns, alteration cardiac mass well enhaced oxidative stress marker levels. Besides, biochemical results validated myocardium histology. Pre-treatment animals mg/kg) HASH or standard agent (metoprolol) prevented ISO-induced alterations above parameters significant 0.01) level metabolic derangements functional alterations. Our research suggests pre-treatment has action can prevent toxicity ISO. Therefore, might be promising therapeutic plant further investigated potential properties.

Language: Английский

Citations

0