Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 4, 2025
Circadian
rhythm,
or
the
biological
clock,
is
an
intrinsic
timing
system
present
in
organisms
that
operates
on
a
cycle
of
approximately
24
h.
Nearly
every
cell
human
body
adheres
to
specific
circadian
governing
various
processes
essential
for
overall
health.
REV-ERB,
key
clock-regulating
gene,
plays
crucial
role
maintaining
precision
these
rhythms.
This
gene
influences
many
downstream
targets
associated
with
diverse
pathophysiological
processes,
including
metabolism,
autophagy,
immunity,
inflammation,
and
aging
across
multiple
organs.
REV-ERB
specifically
impacts
cardiac
systolic
function
by
regulating
myocardial
energy
metabolism.
In
contemporary
society,
health
well-being
are
increasingly
challenged
disruptions
such
as
night
shifts,
late-night
activities,
jet
lag.
These
often
lead
rhythm
disorders,
which
now
being
linked
heart
diseases.
review
explored
potential
cardiovascular
system.
Beyond
its
regulation,
could
significantly
influence
physiological
pathological
related
health,
atherosclerosis,
ischemia/reperfusion
injury,
failure.
Mechanistically,
regulate
glucose
lipid
ferroptosis,
mitochondrial
function.
The
highlighted
protective
roles
underlying
mechanisms
diseases,
suggesting
multidisciplinary
research
may
provide
basis
breakthroughs
REV-ERB-targeted
therapies
disorders.
Язык: Английский
Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds
BIO Integration,
Год журнала:
2025,
Номер
6(1)
Опубликована: Янв. 1, 2025
Diabetes
mellitus
(DM)
is
a
widespread
metabolic
disorder
with
profound
effects
on
vital
organs.
Often
referred
to
as
“systemic”
or
“multi-organ”
due
the
impact
key
organs,
such
kidneys,
pancreas,
eyes,
and
heart,
DM
characterized
by
elevated
blood
glucose
levels
insufficient
insulin
production.
consists
of
three
subtypes
(type
1
DM,
type
2
gestational
DM).
Approximately
537
million
adults
are
living
number
predicted
increase
643
2030,
according
International
Federation
(IDF)
data.
With
rising
prevalence
Pan
American
Health
Organization
World
estimate
an
age-standardized
mortality
rate
20.9
deaths
per
100,000
people.
Therefore,
it
important
study
prevention
cure
determine
underlying
mechanism
regulation.
Numerous
receptors
pathways
help
regulate
DM.
This
article
delves
into
intricate
regulatory
mechanisms
involving
pathways,
K
ATP
(sulfonylurea),
5′AMP-activated
protein
kinase
enzyme
(biguanides),
PPAR
gamma,
alpha-glucosidase,
Glucose
transporters
(GLUT4),
dipeptide
peptidase-4
(DPP-4),
sodium-glucose
co-transporters
(SGLT2).
The
highlights
recent
advances
from
2020–2024
in
synthesizing
compounds
targeting
specific
for
diabetes
management.
In
so
doing,
insights
newly
synthesized
compounds,
marketed
drugs,
phytoconstituents,
drugs
currently
clinical
trials
will
be
provided.
role
each
receptor
maintaining
homeostasis
reviewed
detail
various
potential
effective
antidiabetic
agents
evaluated.
comprehensive
review
presents
pharmacologic
these
in-depth
analysis
promising
new
drug
candidates.
Язык: Английский
NDUFAB1 as a Novel Regulator of NEFA-Induced Metabolic Dysfunction in Bovine Adipocytes
Animals,
Год журнала:
2025,
Номер
15(11), С. 1618 - 1618
Опубликована: Май 30, 2025
Elevated
non-esterified
fatty
acid
(NEFA)
levels
are
closely
associated
with
metabolic
disorders
in
dairy
cattle,
yet
their
direct
effects
on
adipocyte
physiology
remain
poorly
understood.
In
this
study,
we
demonstrate
that
high
NEFA
concentrations
significantly
impair
bovine
function
by
simultaneously
inhibiting
proliferation/differentiation
(p
<
0.01)
and
promoting
pathological
lipid
deposition.
Through
integrated
transcriptomic
functional
analyses,
identified
NDUFAB1
as
a
central
regulator
counteracts
NEFA-induced
dysfunction.
Mechanistically,
activation
attenuates
the
cytotoxic
of
excessive
exposure.
These
findings
provide
both
fundamental
insights
into
energy
metabolism
regulation
potential
therapeutic
target
(NDUFAB1)
for
preventing
diseases.
Язык: Английский