Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds DOI Creative Commons
Pallavi Pandey, Vikash Jakhmola, Supriyo Saha

et al.

BIO Integration, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Diabetes mellitus (DM) is a widespread metabolic disorder with profound effects on vital organs. Often referred to as “systemic” or “multi-organ” due the impact key organs, such kidneys, pancreas, eyes, and heart, DM characterized by elevated blood glucose levels insufficient insulin production. consists of three subtypes (type 1 DM, type 2 gestational DM). Approximately 537 million adults are living number predicted increase 643 2030, according International Federation (IDF) data. With rising prevalence Pan American Health Organization World estimate an age-standardized mortality rate 20.9 deaths per 100,000 people. Therefore, it important study prevention cure determine underlying mechanism regulation. Numerous receptors pathways help regulate DM. This article delves into intricate regulatory mechanisms involving pathways, K ATP (sulfonylurea), 5′AMP-activated protein kinase enzyme (biguanides), PPAR gamma, alpha-glucosidase, Glucose transporters (GLUT4), dipeptide peptidase-4 (DPP-4), sodium-glucose co-transporters (SGLT2). The highlights recent advances from 2020–2024 in synthesizing compounds targeting specific for diabetes management. In so doing, insights newly synthesized compounds, marketed drugs, phytoconstituents, drugs currently clinical trials will be provided. role each receptor maintaining homeostasis reviewed detail various potential effective antidiabetic agents evaluated. comprehensive review presents pharmacologic these in-depth analysis promising new drug candidates.

Language: Английский

Role of circadian transcription factor REV-ERB in cardiovascular diseases: a review DOI Creative Commons
Chunling Wang, Jia‐Shu Yang, Junying Yuan

et al.

Frontiers in Cardiovascular Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 4, 2025

Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24 h. Nearly every cell human body adheres to specific circadian governing various processes essential for overall health. REV-ERB, key clock-regulating gene, plays crucial role maintaining precision these rhythms. This gene influences many downstream targets associated with diverse pathophysiological processes, including metabolism, autophagy, immunity, inflammation, and aging across multiple organs. REV-ERB specifically impacts cardiac systolic function by regulating myocardial energy metabolism. In contemporary society, health well-being are increasingly challenged disruptions such as night shifts, late-night activities, jet lag. These often lead rhythm disorders, which now being linked heart diseases. review explored potential cardiovascular system. Beyond its regulation, could significantly influence physiological pathological related health, atherosclerosis, ischemia/reperfusion injury, failure. Mechanistically, regulate glucose lipid ferroptosis, mitochondrial function. The highlighted protective roles underlying mechanisms diseases, suggesting multidisciplinary research may provide basis breakthroughs REV-ERB-targeted therapies disorders.

Language: Английский

Citations

0
Recent Developments in Diabetes Management: Exploring Receptors, Pathways, and Compounds DOI Creative Commons
Pallavi Pandey, Vikash Jakhmola, Supriyo Saha

et al.

BIO Integration, Journal Year: 2025, Volume and Issue: 6(1)

Published: Jan. 1, 2025

Diabetes mellitus (DM) is a widespread metabolic disorder with profound effects on vital organs. Often referred to as “systemic” or “multi-organ” due the impact key organs, such kidneys, pancreas, eyes, and heart, DM characterized by elevated blood glucose levels insufficient insulin production. consists of three subtypes (type 1 DM, type 2 gestational DM). Approximately 537 million adults are living number predicted increase 643 2030, according International Federation (IDF) data. With rising prevalence Pan American Health Organization World estimate an age-standardized mortality rate 20.9 deaths per 100,000 people. Therefore, it important study prevention cure determine underlying mechanism regulation. Numerous receptors pathways help regulate DM. This article delves into intricate regulatory mechanisms involving pathways, K ATP (sulfonylurea), 5′AMP-activated protein kinase enzyme (biguanides), PPAR gamma, alpha-glucosidase, Glucose transporters (GLUT4), dipeptide peptidase-4 (DPP-4), sodium-glucose co-transporters (SGLT2). The highlights recent advances from 2020–2024 in synthesizing compounds targeting specific for diabetes management. In so doing, insights newly synthesized compounds, marketed drugs, phytoconstituents, drugs currently clinical trials will be provided. role each receptor maintaining homeostasis reviewed detail various potential effective antidiabetic agents evaluated. comprehensive review presents pharmacologic these in-depth analysis promising new drug candidates.

Language: Английский

Citations

0