Medicine,
Год журнала:
2020,
Номер
99(35), С. e22035 - e22035
Опубликована: Авг. 26, 2020
Imbalances
in
the
gut
microbiota
mediate
progression
of
neurodegenerative
diseases
such
as
Parkinson's
disease
(PD).
Fecal
transplantation
(FMT)
is
currently
being
explored
a
potential
therapy
for
PD.
The
objective
this
study
was
to
assess
efficacy
and
safety
FMT
on
Fifteen
PD
patients
were
included,
10
them
received
via
colonoscopy
(colonic
group)
5
nasal-jejunal
tube
(nasointestinal
group).
score
PSQI,
HAMD,
HAMA,
PDQ-39,
NMSQ
UPDRS-III
significantly
decreased
after
treatment
(all
P
<
.05).
Colonic
group
showed
significant
improvement
longer
maintenance
compared
with
nasointestinal
(P
=
.002).
Two
achieved
self-satisfying
outcomes
that
last
more
than
24
months.
However,
had
no
therapeutic
effect,
although
slightly
reduced.
There
satisfied
3
Among
15
patients,
there
cases
adverse
events
(AEs),
including
diarrhea
(2
cases),
abdominal
pain
cases)
flatulence
(1
case).
These
AEs
mild
self-limiting.
We
conclude
can
relieve
motor
non-motor
symptoms
acceptable
Compared
FMT,
colonic
seems
better
preferable.
Journal of Neuroinflammation,
Год журнала:
2019,
Номер
16(1)
Опубликована: Май 22, 2019
Alzheimer's
disease
(AD)
is
a
neurodegenerative
whose
various
pathophysiological
aspects
are
still
being
investigated.
Recently,
it
has
been
hypothesized
that
AD
may
be
associated
with
dysbiosis
of
microbes
in
the
intestine.
In
fact,
intestinal
flora
able
to
influence
activity
brain
and
cause
its
dysfunctions.Given
growing
interest
this
topic,
purpose
review
analyze
role
antibiotics
relation
gut
microbiota
AD.
first
part
review,
we
briefly
theories
supporting
hypothesis
can
pathophysiology.
second
part,
possible
these
events.
Antibiotics
normally
used
remove
or
prevent
bacterial
colonization
human
body,
without
targeting
specific
types
bacteria.
As
result,
broad-spectrum
greatly
affect
composition
microbiota,
reduce
biodiversity,
delay
for
long
period
after
administration.
Thus,
action
could
wide
even
opposite,
depending
on
type
antibiotic
microbiome
pathogenesis.Alteration
induce
changes
activity,
which
raise
possibility
therapeutic
manipulation
other
neurological
disorders.
This
field
research
currently
undergoing
great
development,
but
applications
far
away.
Whether
achieved
using
not
known.
The
future
depends
progresses
We
must
understand
how
when
bacteria
act
promote
Once
well
established,
one
think
modifications
use
pre-,
pro-,
produce
effects.
The Annual Review of Pharmacology and Toxicology,
Год журнала:
2019,
Номер
60(1), С. 477 - 502
Опубликована: Сен. 11, 2019
The
traditional
fields
of
pharmacology
and
toxicology
are
beginning
to
consider
the
substantial
impact
our
gut
microbiota
has
on
host
physiology.
microbiota-gut-brain
axis
is
emerging
as
a
particular
area
interest
potential
new
therapeutic
target
for
effective
treatment
central
nervous
system
disorders,
in
addition
being
cause
drug
side
effects.
Microbiota-gut-brain
signaling
can
occur
via
several
pathways,
including
immune
system,
recruitment
neurochemical
signaling,
direct
enteric
routes
vagus
nerve,
production
bacterial
metabolites.
Altered
microbial
profiles
have
been
described
psychiatric
neurological
disorders.
Psychobiotics,
live
biotherapeutics
or
substances
whose
beneficial
effects
brain
bacterially
mediated,
currently
investigated
and/or
adjunctive
therapies
neurodevelopmental
disorders
possibly
neurodegenerative
disease,
they
may
emerge
options
clinical
management
Clinical Microbiology Reviews,
Год журнала:
2022,
Номер
35(1)
Опубликована: Янв. 5, 2022
The
human
body
is
full
of
an
extensive
number
commensal
microbes,
consisting
bacteria,
viruses,
and
fungi,
collectively
termed
the
microbiome.
initial
acquisition
microbiota
occurs
from
both
external
maternal
environments,
vast
majority
them
colonize
gastrointestinal
tract
(GIT).
These
microbial
communities
play
a
central
role
in
maturation
development
immune
system,
nervous
GIT
system
are
also
responsible
for
essential
metabolic
pathways.
Various
factors,
including
host
genetic
predisposition,
environmental
lifestyle,
diet,
antibiotic
or
nonantibiotic
drug
use,
etc.,
affect
composition
gut
microbiota.
Recent
publications
have
highlighted
that
imbalance
microflora,
known
as
dysbiosis,
associated
with
onset
progression
neurological
disorders.
Moreover,
characterization
microbiome-host
cross
talk
pathways
provides
insight
into
novel
therapeutic
strategies.
Novel
preclinical
clinical
research
on
interventions
related
to
microbiome
treating
conditions,
autism
spectrum
disorders,
Parkinson's
disease,
schizophrenia,
multiple
sclerosis,
Alzheimer's
epilepsy,
stroke,
hold
significant
promise.
This
review
aims
present
comprehensive
overview
potential
involvement
pathogenesis
particular
emphasis
microbe-based
therapies
and/or
diagnostic
biomarkers.
discusses
health
benefits
administration
probiotics,
prebiotics,
postbiotics,
synbiotics
fecal
transplantation
Frontiers in Immunology,
Год журнала:
2019,
Номер
9
Опубликована: Янв. 6, 2019
The
interaction
between
the
human
microbiome
and
immune
system
has
an
effect
on
several
metabolic
functions
impacts
our
well-being.
Additionally,
humans
microbes
can
also
play
a
key
role
in
determining
wellness
or
disease
status
of
body.
Dysbiosis
is
related
to
plethora
diseases,
including
skin,
inflammatory,
metabolic,
neurological
disorders.
A
better
understanding
host-microbe
essential
for
diagnosis
appropriate
treatment
these
ailments.
significance
host
health
led
emergence
new
therapeutic
approaches
focused
prescribed
manipulation
microbiome,
either
by
removing
harmful
taxa
reinstating
missing
beneficial
functional
roles
they
perform.
Culturing
large
numbers
microbial
laboratory
problematic
at
best,
if
not
impossible.
Consequently,
this
makes
it
very
difficult
comprehensively
catalogue
individual
members
comprising
specific
as
well
how
communities
function
influence
host-pathogen
interactions.
Recent
advances
sequencing
technologies
computational
tools
have
allowed
increasing
number
metagenomic
studies
be
performed.
These
provided
insights
into
other
environments.
In
present
review,
agent
its
discussed.
Advances
high-throughput
surveying
interactions
are
correlation
composition
infectious
diseases
described
previously
reported
covered
well.
Lastly,
recent
state-of-the-art
bioinformatics
software,
workflows,
applications
analysing
data
summarized.
Translational Psychiatry,
Год журнала:
2019,
Номер
9(1)
Опубликована: Сен. 12, 2019
Western
societies
notice
an
increasing
interest
in
plant-based
eating
patterns
such
as
vegetarian
and
vegan,
yet
potential
effects
on
the
body
brain
are
a
matter
of
debate.
Therefore,
we
systematically
reviewed
existing
human
interventional
studies
putative
diet
metabolism
cognition,
what
is
known
about
underlying
mechanisms.
Using
search
terms
"plant-based
OR
vegan
AND
intervention"
PubMed
filtered
for
clinical
trials
humans
retrieved
205
out
which
27,
plus
additional
extending
selection
to
another
five
studies,
were
eligible
inclusion
based
three
independent
ratings.
We
found
robust
evidence
short-
moderate-term
beneficial
diets
versus
conventional
(duration
≤
24
months)
weight
status,
energy
systemic
inflammation
healthy
participants,
obese
type-2
diabetes
patients.
Initial
experimental
proposed
novel
microbiome-related
pathways,
by
modulate
gut
microbiome
towards
favorable
diversity
bacteria
species,
functional
"bottom
up"
signaling
diet-induced
microbial
changes
remains
highly
speculative.
In
addition,
little
known,
cognitive
linked
diets.
Thus,
causal
impact
functions,
mental
neurological
health
respective
mechanisms
has
be
demonstrated.
sum,
raises
opportunity
developing
preventive
therapeutic
strategies
against
obesity,
disorders
related
comorbidities.
Still,
functions
well
remain
largely
unexplored
new
need
address
these
questions.
Biomedicine & Pharmacotherapy,
Год журнала:
2021,
Номер
139, С. 111661 - 111661
Опубликована: Май 8, 2021
During
the
past
decade,
accumulating
evidence
from
research
highlights
suggested
effects
of
bacterial
communities
human
gut
microbiota
and
their
metabolites
on
health
disease.
In
this
regard,
microbiota-derived
receptors,
beyond
immune
system,
maintain
metabolism
homeostasis,
which
is
essential
to
host's
by
balancing
utilization
intake
nutrients.
It
has
been
shown
that
dysbiosis
can
cause
pathology
altered
metabolites'
formation,
resulting
in
dysregulation
system
metabolism.
The
short-chain
fatty
acids
(SCFAs),
such
as
butyrate,
acetate,
succinate,
are
produced
due
fermentation
process
bacteria
gut.
noted
remodeling
associated
with
pathophysiology
several
neurological
disorders,
Alzheimer's
disease,
multiple
sclerosis,
Parkinson's
amyotrophic
lateral
stress,
anxiety,
depression,
autism,
vascular
dementia,
schizophrenia,
stroke,
neuromyelitis
optica
spectrum
among
others.
This
review
will
discuss
current
most
significant
studies
dealing
some
SCFAs
microbial
selected
disorders.
Brain Research Bulletin,
Год журнала:
2022,
Номер
182, С. 44 - 56
Опубликована: Фев. 11, 2022
Depression
is
the
most
common
mental
disorder
and
a
leading
cause
of
disability
worldwide.
Despite
abundant
research,
precise
mechanisms
underlying
pathophysiology
depression
remain
elusive.
Accumulating
evidence
from
preclinical
clinical
studies
suggests
that
alterations
in
gut
microbiota,
microbe-derived
short-chain
fatty
acids,
D-amino
acids
metabolites
play
key
role
via
brain–gut–microbiota
axis,
including
neural
immune
systems.
Notably,
axis
might
crucial
susceptibility
versus
resilience
rodents
exposed
to
stress.
Vagotomy
reported
block
depression-like
phenotypes
after
fecal
microbiota
transplantation
"depression-related"
microbiome,
suggesting
vagus
nerve
influences
through
axis.
In
this
article,
we
review
recent
findings
regarding
discuss
its
potential
as
therapeutic
target
for
depression.
International Journal of Molecular Sciences,
Год журнала:
2022,
Номер
23(19), С. 11245 - 11245
Опубликована: Сен. 24, 2022
Modulating
the
gut
microbiome
and
its
influence
on
human
health
is
subject
of
intense
research.
The
microbiota
could
be
associated
not
only
with
gastroenterological
diseases
but
also
psychiatric
disorders.
importance
factors
such
as
stress,
mode
delivery,
role
probiotics,
circadian
clock
system,
diet,
occupational
environmental
exposure
in
relationship
between
brain
function
through
bidirectional
communication,
described
"the
microbiome-gut-brain
axis",
especially
underlined.
In
this
review,
we
discuss
link
intestinal
host
response
involving
different
pathways
nervous
system
(e.g.,
neurotransmitters,
endocrine
immunological
mechanisms,
or
bacterial
metabolites).
We
review
alterations
their
results
development
disorders,
including
major
depressive
disorder
(MDD),
schizophrenia
(SCZ),
bipolar
(BD),
autism
spectrum
(ASD),
attention-deficit
hyperactivity
(ADHD).