Aging and Disease,
Год журнала:
2024,
Номер
15(1), С. 74 - 74
Опубликована: Янв. 1, 2024
Amyotrophic
Lateral
Sclerosis
(ALS)
is
a
devastating
neurodegenerative
disease
which
strongly
associated
with
age.
The
incidence
of
ALS
increases
from
the
age
40
and
peaks
between
ages
65
70.
Most
patients
die
respiratory
muscle
paralysis
or
lung
infections
within
three
to
five
years
appearance
symptoms,
dealing
huge
blow
their
families.
With
aging
populations,
improved
diagnostic
methods
changes
in
reporting
criteria,
likely
show
an
upward
trend
coming
decades.
Despite
extensive
researches
have
been
done,
cause
pathogenesis
remains
unclear.
In
recent
decades,
large
quantities
studies
focusing
on
gut
microbiota
shown
that
its
metabolites
seem
change
evolvement
through
brain-gut-microbiota
axis,
turn,
progression
will
exacerbate
imbalance
microbiota,
thereby
forming
vicious
cycle.
This
suggests
further
exploration
identification
function
may
be
crucial
break
bottleneck
diagnosis
treatment
this
disease.
Hence,
current
review
summarizes
discusses
latest
research
advancement
future
directions
so
as
help
relevant
researchers
gain
correlative
information
instantly.
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
164, С. 114985 - 114985
Опубликована: Июнь 11, 2023
The
gut
microbiota
is
indispensable
for
maintaining
host
health
by
enhancing
the
host's
digestive
capacity,
safeguarding
intestinal
epithelial
barrier,
and
preventing
pathogen
invasion.
Additionally,
exhibits
a
bidirectional
interaction
with
immune
system
promotes
of
to
mature.
Dysbiosis
microbiota,
primarily
caused
factors
such
as
genetic
susceptibility,
age,
BMI,
diet,
drug
abuse,
significant
contributor
inflammatory
diseases.
However,
mechanisms
underlying
diseases
resulting
from
dysbiosis
lack
systematic
categorization.
In
this
study,
we
summarize
normal
physiological
functions
symbiotic
in
healthy
state
demonstrate
that
when
occurs
due
various
external
factors,
are
lost,
leading
pathological
damage
lining,
metabolic
disorders,
barrier
damage.
This,
turn,
triggers
disorders
eventually
causes
systems.
These
discoveries
provide
fresh
perspectives
on
how
diagnose
treat
unrecognized
variables
might
affect
link
between
illnesses
need
further
studies
extensive
basic
clinical
research
will
still
be
required
investigate
relationship
future.
Frontiers in Neurology,
Год журнала:
2023,
Номер
14
Опубликована: Май 15, 2023
Alzheimer's
disease
(AD),
is
a
chronic
age-related
progressive
neurodegenerative
disorder,
characterized
by
neuroinflammation
and
extracellular
aggregation
of
Aβ
peptide.
affects
every
1
in
14
individuals
aged
65
years
above.
Recent
studies
suggest
that
the
intestinal
microbiota
plays
crucial
role
modulating
neuro-inflammation
which
turn
influences
deposition.
The
gut
brain
interact
with
each
other
through
nervous
system
chemical
means
via
blood-brain
barrier,
termed
Microbiota
Gut
Brain
Axis
(MGBA).
It
suggested
can
impact
host's
health,
numerous
factors,
such
as
nutrition,
pharmacological
interventions,
lifestyle,
geographic
location,
alter
composition.
Although,
exact
relationship
between
dysbiosis
AD
still
elusive,
several
mechanisms
have
been
proposed
drivers
their
implications
pathology,
include,
action
bacteria
produce
bacterial
amyloids
lipopolysaccharides
causing
macrophage
dysfunction
leading
to
increased
permeability,
hyperimmune
activation
inflammatory
cytokines
(IL-1β,
IL-6,
IL-8,
NLRP3),
impairment
gut-
blood
barrier
deposition
brain,
etc.
study
micro-organisms
associated
aid
appropriate
model
organisms
has
recognized
phyla
Bacteroidetes
Firmicutes
contain
genus
Escherichia,
Lactobacillus,
Clostridium
,
etc.,
contribute
significantly
pathology.
Modulating
various
means,
use
prebiotics,
probiotics,
antibiotics
or
fecal
matter
transplantation,
thought
be
potential
therapeutic
intervention
for
treatment
AD.
This
review
aims
summarize
our
current
knowledge
on
possible
dysbiosis,
axis
neuroinflammation,
application
novel
targeted
approaches
modulate
Journal of Clinical Medicine,
Год журнала:
2023,
Номер
12(4), С. 1650 - 1650
Опубликована: Фев. 19, 2023
In
humans,
the
gut
microbiota
(GM)
are
known
to
play
a
significant
role
in
metabolism
of
nutrients
and
drugs,
immunomodulation,
pathogen
defense
by
inhabiting
gastrointestinal
tract
(GIT).
The
GM
gut–brain
axis
(GBA)
has
been
documented
for
different
regulatory
mechanisms
associated
pathways
it
shows
behaviors
with
individualized
bacteria.
addition,
as
susceptibility
factor
neurological
disorders
central
nervous
system
(CNS),
regulating
disease
progression
being
amenable
intervention.
Bidirectional
transmission
between
brain
occurs
GBA,
implying
that
performs
neurocrine,
endocrine,
immune-mediated
signaling
pathways.
regulates
multiple
supplementing
them
prebiotics,
probiotics,
postbiotics,
synbiotics,
fecal
transplantations,
and/or
antibiotics.
A
well-balanced
diet
is
critically
important
establishing
healthy
GM,
which
can
alter
enteric
(ENS)
regulate
disorders.
Here,
we
have
discussed
function
GBA
from
gut,
neurology
interacts
various
GM.
Furthermore,
highlighted
recent
advances
future
prospects
may
require
addressing
research
concerns
about
Nutrients,
Год журнала:
2023,
Номер
15(21), С. 4631 - 4631
Опубликована: Окт. 31, 2023
The
gut–brain
axis
(GBA)
is
a
complex
bidirectional
communication
network
connecting
the
gut
and
brain.
It
involves
neural,
immune,
endocrine
pathways
between
gastrointestinal
(GI)
tract
central
nervous
system
(CNS).
Perturbations
of
GBA
have
been
reported
in
many
neurodegenerative
disorders
(NDDs),
such
as
Alzheimer’s
disease
(AD),
Parkinson’s
(PD),
amyotrophic
lateral
sclerosis
(ALS),
among
others,
suggesting
possible
role
pathogenesis.
microbiota
pivotal
component
GBA,
alterations
its
composition,
known
dysbiosis,
associated
with
dysfunction
neurodegeneration.
might
influence
homeostasis
CNS
by
modulating
immune
and,
more
directly,
regulating
production
molecules
metabolites
that
systems,
making
it
potential
therapeutic
target.
Preclinical
trials
manipulating
microbial
composition
through
dietary
intervention,
probiotic
prebiotic
supplementation,
fecal
transplantation
(FMT)
provided
promising
outcomes.
However,
clear
mechanism
not
well
understood,
results
are
always
consistent.
Here,
we
provide
an
overview
major
components
approaches
targeting
to
ameliorate
NDDs.
The
occurrence
and
development
of
Parkinson's
disease
(PD)
have
been
demonstrated
to
be
related
gut
dysbiosis,
however,
the
impact
fecal
microbiota
transplantation
(FMT)
on
engraftment
in
PD
patients
is
uncertain.
We
performed
a
randomized,
placebo-controlled
trial
at
Department
Neurology,
Army
Medical
University
Southwest
Hospital
China
(ChiCTR1900021405)
from
February
2019
December
2019.
Fifty-six
participants
with
mild
moderate
(Hoehn-Yahr
stage
1–3)
were
randomly
assigned
FMT
placebo
group,
27
group
completed
whole
trial.
During
follow-up,
no
severe
adverse
effect
was
observed,
treatment
showed
significant
improvement
PD-related
autonomic
symptoms
compared
end
this
(MDS-UPDRS
total
score,
group×time
effect,
B
=
-6.56
[−12.98,
−0.13],
P
<
0.05).
Additionally,
improved
gastrointestinal
disorders
marked
increase
complexity
microecological
system
patients.
This
study
that
through
oral
administration
clinically
feasible
has
potential
improve
effectiveness
current
medications
clinical
Abstract
Background
Remodeling
eubiosis
of
the
gut
microenvironment
may
contribute
to
preventing
occurrence
and
development
depression.
Mounting
experimental
evidence
has
shown
that
complement
C3
signaling
is
associated
with
pathogenesis
depression,
disruption
microbiota
be
an
underlying
cause
system
activation.
However,
mechanism
by
which
participates
in
gut-brain
crosstalk
depression
remains
unknown.
Results
In
present
study,
we
found
chronic
unpredictable
mild
stress
(CUMS)-induced
mice
exhibited
obvious
depression-like
behavior
as
well
cognitive
impairment,
was
significant
dysbiosis,
especially
enrichment
Proteobacteria
elevation
microbiota-derived
lipopolysaccharides
(LPS).
addition,
peripheral
central
activation
C3/CR3-mediated
aberrant
synaptic
pruning
microglia
have
also
been
observed.
Transplantation
from
CUMS-induced
model
into
specific
pathogen-free
germ-free
induced
concomitant
impairment
recipient
mice,
accompanied
increased
C3/CR3
pathway
prefrontal
cortex
abnormalities
microglia-mediated
pruning.
Conversely,
antidepressants
fecal
transplantation
antidepressant-treated
donors
improved
behaviors
restored
microbiome
disturbances
depressed
mice.
Concurrently,
inhibition
pathway,
amelioration
abnormal
pruning,
expression
synapsin
postsynaptic
density
protein
95
were
Collectively,
our
results
revealed
dysbiosis
induces
through
synapse
C3,
key
targeting
microbes
treat
Conclusions
Our
findings
provide
novel
insights
involvement
chemotactic
The
interplay
between
the
gut
microbiota
and
gastrointestinal
hormones
plays
a
pivotal
role
in
health
of
host
development
diseases.
As
vital
component
intestinal
microecosystem,
influences
synthesis
release
many
through
mechanisms
such
as
modulating
environment,
producing
metabolites,
impacting
mucosal
barriers,
generating
immune
inflammatory
responses,
releasing
neurotransmitters.
Conversely,
exert
feedback
regulation
on
by
nutrient
absorption
utilization,
bacterial
biological
behavior
composition.
distributions
are
anatomically
intertwined,
close
interactions
crucial
for
maintaining
homeostasis.
Interventions
leveraging
have
been
employed
clinical
management
metabolic
diseases
bowel
diseases,
bariatric
surgery
fecal
transplantation,
offering
promising
targets
treatment
dysbiosis-related
Liver International,
Год журнала:
2022,
Номер
43(1), С. 221 - 233
Опубликована: Окт. 27, 2022
Observational
epidemiology
studies
suggested
a
relationship
between
the
gut
microbiome
and
primary
liver
cancer.
However,
causal
remains
unclear
because
of
confounding
factors
reverse
causality.
We
aimed
to
explore
role
in
development
cancer,
including
hepatocellular
carcinoma
(HCC)
intrahepatic
cholangiocarcinoma
(ICC).
