Medicine,
Год журнала:
2020,
Номер
99(35), С. e22035 - e22035
Опубликована: Авг. 26, 2020
Imbalances
in
the
gut
microbiota
mediate
progression
of
neurodegenerative
diseases
such
as
Parkinson's
disease
(PD).
Fecal
transplantation
(FMT)
is
currently
being
explored
a
potential
therapy
for
PD.
The
objective
this
study
was
to
assess
efficacy
and
safety
FMT
on
Fifteen
PD
patients
were
included,
10
them
received
via
colonoscopy
(colonic
group)
5
nasal-jejunal
tube
(nasointestinal
group).
score
PSQI,
HAMD,
HAMA,
PDQ-39,
NMSQ
UPDRS-III
significantly
decreased
after
treatment
(all
P
<
.05).
Colonic
group
showed
significant
improvement
longer
maintenance
compared
with
nasointestinal
(P
=
.002).
Two
achieved
self-satisfying
outcomes
that
last
more
than
24
months.
However,
had
no
therapeutic
effect,
although
slightly
reduced.
There
satisfied
3
Among
15
patients,
there
cases
adverse
events
(AEs),
including
diarrhea
(2
cases),
abdominal
pain
cases)
flatulence
(1
case).
These
AEs
mild
self-limiting.
We
conclude
can
relieve
motor
non-motor
symptoms
acceptable
Compared
FMT,
colonic
seems
better
preferable.
Nutrients,
Год журнала:
2020,
Номер
12(3), С. 605 - 605
Опубликована: Фев. 26, 2020
The
importance
of
gut
microbiota
in
health
and
disease
is
being
highlighted
by
numerous
research
groups
worldwide.
Atherosclerosis,
the
leading
cause
heart
stroke,
responsible
for
about
50%
all
cardiovascular
deaths.
Recently,
dysbiosis
has
been
identified
as
a
remarkable
factor
to
be
considered
pathogenesis
diseases
(CVDs).
In
this
review,
we
briefly
discuss
how
external
factors
such
dietary
physical
activity
habits
influence
host-microbiota
atherogenesis,
potential
mechanisms
host
blood
pressure
alterations
prevalence
those
bacterial
genera
affecting
vascular
tone
development
hypertension.
We
will
also
examining
therapeutic
target
prevention
CVDs
beneficial
probiotic
administration
related
risks.
All
these
new
insights
might
lead
novel
analysis
CVD
therapeutics
based
on
microbiota.
Journal of Neuroinflammation,
Год журнала:
2021,
Номер
18(1)
Опубликована: Ноя. 4, 2021
Chronic
unpredictable
mild
stress
(CUMS)
can
not
only
lead
to
depression-like
behavior
but
also
change
the
composition
of
gut
microbiome.
Regulating
microbiome
have
an
antidepressant
effect,
mechanism
by
which
it
improves
depressive
symptoms
is
clear.
Short-chain
fatty
acids
(SCFAs)
are
small
molecular
compounds
produced
fermentation
non-digestible
carbohydrates.
SFCAs
ubiquitous
in
intestinal
endocrine
and
immune
cells,
making
them
important
mediators
microbiome-regulated
body
functions.
The
balance
between
pro-
anti-inflammatory
microglia
plays
role
occurrence
treatment
depression
caused
chronic
stress.
Non-absorbable
antibiotic
rifaximin
regulate
structure
We
hypothesized
that
protects
against
stress-induced
inflammation
behaviors
regulating
abundance
fecal
microbial
metabolites
microglial
functions.We
administered
150
mg/kg
intragastrically
rats
exposed
CUMS
for
4
weeks
investigated
microbiome,
content
short-chain
serum
brain,
functional
profiles
hippocampal
neurogenesis.Our
results
show
ameliorated
depressive-like
induced
CUMS,
as
reflected
sucrose
preference,
open
field
test
Morris
water
maze.
Rifaximin
increased
relative
Ruminococcaceae
Lachnospiraceae,
were
significantly
positively
correlated
with
high
level
butyrate
brain.
factors
released
microglia,
prevented
neurogenic
abnormalities
CUMS.These
suggest
inflammatory
function
play
a
protective
pubertal
neurodevelopment
during
acids.
Microorganisms,
Год журнала:
2020,
Номер
8(4), С. 527 - 527
Опубликована: Апрель 7, 2020
Gut
microbiota
play
an
important
role
in
maintaining
intestinal
health
and
are
involved
the
metabolism
of
carbohydrates,
lipids,
amino
acids.
Recent
studies
have
shown
that
central
nervous
system
(CNS)
enteric
(ENS)
can
interact
with
gut
to
regulate
nutrient
metabolism.
The
vagal
nerve
communicates
between
CNS
ENS
control
gastrointestinal
tract
functions
feeding
behavior.
Vagal
afferent
neurons
also
express
receptors
for
peptides
secreted
from
enteroendocrine
cells
(EECs),
such
as
cholecystokinin
(CCK),
ghrelin,
leptin,
peptide
tyrosine
(PYY),
glucagon-like
peptide-1
(GLP-1),
5-hydroxytryptamine
(5-HT;
serotonin).
levels
these
influence
pathway
thus
via
microbiota-gut-brain
axis.
In
addition,
bile
acids,
short-chain
fatty
acids
(SCFAs),
trimethylamine-N-oxide
(TMAO),
Immunoglobulin
A
(IgA)
exert
metabolic
through
microbiota-gut-liver
This
review
is
mainly
focused
on
neuroendocrine
regulation
microbiota-gut-brain-liver
Medicine,
Год журнала:
2020,
Номер
99(35), С. e22035 - e22035
Опубликована: Авг. 26, 2020
Imbalances
in
the
gut
microbiota
mediate
progression
of
neurodegenerative
diseases
such
as
Parkinson's
disease
(PD).
Fecal
transplantation
(FMT)
is
currently
being
explored
a
potential
therapy
for
PD.
The
objective
this
study
was
to
assess
efficacy
and
safety
FMT
on
Fifteen
PD
patients
were
included,
10
them
received
via
colonoscopy
(colonic
group)
5
nasal-jejunal
tube
(nasointestinal
group).
score
PSQI,
HAMD,
HAMA,
PDQ-39,
NMSQ
UPDRS-III
significantly
decreased
after
treatment
(all
P
<
.05).
Colonic
group
showed
significant
improvement
longer
maintenance
compared
with
nasointestinal
(P
=
.002).
Two
achieved
self-satisfying
outcomes
that
last
more
than
24
months.
However,
had
no
therapeutic
effect,
although
slightly
reduced.
There
satisfied
3
Among
15
patients,
there
cases
adverse
events
(AEs),
including
diarrhea
(2
cases),
abdominal
pain
cases)
flatulence
(1
case).
These
AEs
mild
self-limiting.
We
conclude
can
relieve
motor
non-motor
symptoms
acceptable
Compared
FMT,
colonic
seems
better
preferable.
