The Microbiota-Gut-Brain Axis: From Motility to Mood

Gastroenterology, Год журнала: 2021, Номер 160(5), С. 1486 - 1501

Опубликована: Янв. 22, 2021

Язык: Английский

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Microbiota from young mice counteracts selective age-associated behavioral deficits

Nature Aging, Год журнала: 2021, Номер 1(8), С. 666 - 676

Опубликована: Авг. 9, 2021

Язык: Английский

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Parkinson’s disease-associated alterations of the gut microbiome predict disease-relevant changes in metabolic functions

BMC Biology, Год журнала: 2020, Номер 18(1)

Опубликована: Июнь 9, 2020

Parkinson's disease (PD) is a systemic clinically defined by the degeneration of dopaminergic neurons in brain. While alterations gut microbiome composition have been reported PD, their functional consequences remain unclear. Herein, we addressed this question an analysis stool samples from Luxembourg Study (n = 147 typical PD cases, n 162 controls).All individuals underwent detailed clinical assessment, including neurological examinations and neuropsychological tests followed self-reporting questionnaires. Stool these were first analysed 16S rRNA gene sequencing. Second, predicted potential secretion for 129 microbial metabolites through personalised metabolic modelling using data genome-scale reconstructions human microbes. Our key results include following. Eight genera seven species changed significantly relative abundances between patients healthy controls. PD-associated patterns statistically depended on sex, age, BMI, constipation. Particularly, Bilophila Paraprevotella associated with Hoehn Yahr staging after controlling duration. Furthermore, microbiomes revealed nine increased methionine cysteinylglycine. The pantothenic acid production was linked to presence specific non-motor symptoms.Our suggest that can translate into substantial differences affecting host metabolism phenotype.

Язык: Английский

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Factors related to mental health of inpatients with COVID-19 in Wuhan, China

Brain Behavior and Immunity, Год журнала: 2020, Номер 89, С. 587 - 593

Опубликована: Июль 15, 2020

Язык: Английский

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Lactobacillus and intestinal diseases: Mechanisms of action and clinical applications

Microbiological Research, Год журнала: 2022, Номер 260, С. 127019 - 127019

Опубликована: Апрель 9, 2022

Язык: Английский

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Exposure to polystyrene microplastics impairs hippocampus-dependent learning and memory in mice

Journal of Hazardous Materials, Год журнала: 2022, Номер 430, С. 128431 - 128431

Опубликована: Фев. 4, 2022

Microplastics (MPs) pollution has become a serious environmental issue worldwide, but its potential effects on health remain unknown. The administration of polystyrene MPs (PS-MPs) to mice for eight weeks impaired learning and memory behavior. PS-MPs were detected in the brain especially hippocampus these mice. Concurrently, had decreased levels immediate-early genes, aberrantly enhanced synaptic glutamate AMPA receptors, elevated neuroinflammation, all which are critical plasticity memory. Interestingly, ablation vagus nerve, modulator gut-brain axis, improved function These results indicate that exposure alters expression neuronal activity-dependent genes proteins, increases neuroinflammation hippocampus, subsequently causing behavioral changes through nerve-dependent pathway. Our findings shed light adverse impacts hippocampal

Язык: Английский

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Sex and gender in neurodevelopmental conditions

Nature Reviews Neurology, Год журнала: 2023, Номер 19(3), С. 136 - 159

Опубликована: Фев. 6, 2023

Язык: Английский

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Mining microbes for mental health: Determining the role of microbial metabolic pathways in human brain health and disease

Neuroscience & Biobehavioral Reviews, Год журнала: 2021, Номер 125, С. 698 - 761

Опубликована: Март 5, 2021

There is increasing knowledge regarding the role of microbiome in modulating brain and behaviour. Indeed, actions microbial metabolites are key for appropriate gut-brain communication humans. Among these metabolites, short-chain fatty acids, tryptophan, bile acid metabolites/pathways show strong preclinical evidence involvement various aspects function With identification neuroactive modules, new predictive tools can be applied to existing datasets. We identified 278 studies relating human microbiota-gut-brain axis which included sequencing data. This spanned across psychiatric neurological disorders with a small number also focused on normal behavioural development. consistent bioinformatics pipeline, thirty-five datasets were reanalysed from publicly available raw files remainder summarised collated. studies, we uncovered disease-related alterations metabolic pathways Alzheimer's Disease, schizophrenia, anxiety depression. Amongst that could not reanalysed, many technical limitations hindered discovery specific biomarkers microbes or conserved studies. Future warranted confirm our findings. propose guidelines future analysis increase reproducibility consistency within field.

Язык: Английский

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Fermented foods: Harnessing their potential to modulate the microbiota-gut-brain axis for mental health

Neuroscience & Biobehavioral Reviews, Год журнала: 2024, Номер 158, С. 105562 - 105562

Опубликована: Янв. 25, 2024

Over the past two decades, whole food supplementation strategies have been leveraged to target mental health. In addition, there has increasing attention on ability of gut microbes, so called psychobiotics, positively impact behaviour though microbiota-gut-brain axis. Fermented foods offer themselves as a combined microbiota modulating intervention. Indeed, they contain potentially beneficial microbial metabolites and other bioactives, which are being harnessed axis for positive benefits. This review highlights diverse nature fermented in terms raw materials used type fermentation employed, summarises their potential shape composition microbiota, brain communication pathways including immune system and, ultimately, modulate Throughout, we identify knowledge gaps challenges faced designing human studies investigating health-promoting individual or components thereof. Importantly, also suggest solutions that can advance understanding therapeutic merit

Язык: Английский

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Microbiota‐gut‐brain axis as a regulator of reward processes

Journal of Neurochemistry, Год журнала: 2020, Номер 157(5), С. 1495 - 1524

Опубликована: Дек. 26, 2020

Abstract Our gut harbours trillions of microorganisms essential for the maintenance homeostasis and host physiology in health disease. In last decade, there has been a growing interest understanding bidirectional pathway communication between our microbiota central nervous system. With regard to reward processes is accumulating evidence from both animal human studies that this axis may be key factor gating valence. Focusing on mesocorticolimbic pathway, we will discuss how intestinal involved regulating brain functions, natural (i.e. eating, social or sexual behaviours) non‐natural reinforcers (drug addiction behaviours including those relevant alcohol, psychostimulants, opioids cannabinoids). We integrate preclinical clinical suggesting microbiota‐gut‐brain could implicated development disorders associated with alterations system it targeted as promising therapeutic strategy. image Cover Image issue: https://doi.org/10.1111/jnc.15065 .

Язык: Английский

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