Dietary Interventions in Parkinson’s Disease

Journal of Parkinson s Disease, Год журнала: 2024, Номер 14(1), С. 1 - 16

Опубликована: Янв. 23, 2024

Several dietary patterns and nutritional supplements have been linked to the development, progression, symptomatic treatment of Parkinson’s disease (PD). Most evidence, at this point, is preliminary based largely on observational studies. Interventional studies are scarce, so evidence effectiveness remains inconclusive. Dietary interventions could, analogous exercise, potentially a beneficial effect symptoms as well progression should therefore be researched in high quality Further work also needed study whether interventions, when applied an at-risk population, any potential postpone onset manifest PD. In paper, we summarize all ongoing clinical trials We found 10 studies, aimed different intervention. These mostly exploratory nature or represent phase I II focusing safety, biological responses, effects. Taken together, conclude that research persons with PD still its early days. The results various expected generate new hypotheses will help shape agenda for future important topic.

Язык: Английский

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The tryptophan metabolic pathway of the microbiome and host cells in health and disease

International Immunology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 13, 2024

Abstract The intricate and dynamic tryptophan (Trp) metabolic pathway in both the microbiome host cells highlights its profound implications for health disease. This involves complex interactions between cellular bacteria processes, producing bioactive compounds such as 5-hydroxytryptamine (5-HT) kynurenine derivatives. Immune responses to Trp metabolites through specific receptors have been explored, highlighting role of aryl hydrocarbon receptor inflammation modulation. Dysregulation this is implicated various diseases, Alzheimer’s Parkinson’s mood disorders, neuronal autoimmune diseases multiple sclerosis (MS), cancer. In article, we describe impact 5-HT, Trp, indole, on Furthermore, review microbiome-derived that affect immune contribute maintaining homeostasis, especially an experimental encephalitis model MS.

Язык: Английский

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Associations between nutrient intake and osteoarthritis based on NHANES 1999 to 2018 cross sectional study

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 6, 2025

The relationship between nutrient intake and osteoarthritis (OA) remains unclear. This study utilized data from the National Health Nutrition Examination Survey (NHANES) in a multi-cycle retrospective cohort to explore associations of six nutrients—carbohydrates, dietary fiber, protein, fat, folate, niacin OA. performed cross-sectional analysis using NHANES 1999 2018 investigate nutrients Univariate multivariate weighted logistic regression models, along with restricted cubic splines (RCS), were applied assess A total 32,484 participants included study, whom 1864 diagnosed OA, resulting prevalence rate 5.74%. Multivariate consistently demonstrated that folic acid, nicotinic acid negatively associated presence while protein exhibited J-shaped carbohydrate or fat showed no significant association Compared lowest quartile (Q1), those highest (Q4) had 27%, 28%, 33% lower odds having respectively, after adjusting for potential confounding factors. RCS revealed fiber nonlinear linear followed curve These results suggest higher is reduced likelihood follows curve, moderate offering greatest protection. findings highlight importance balancing optimizing consumption other prevention management Further research needed confirm these clarify underlying mechanisms.

Язык: Английский

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Oxidative Stress in Brain Function

Antioxidants, Год журнала: 2025, Номер 14(3), С. 297 - 297

Опубликована: Фев. 28, 2025

Oxidative stress (OS) is an important factor in the pathophysiology of numerous neurodegenerative disorders, such as Parkinson's disease, multiple sclerosis, cerebrovascular pathology or Alzheimer's disease. OS also significantly influences progression among various disorders. The imbalance between formation reactive oxygen species (ROS) and body's capacity to neutralize these toxic byproducts renders brain susceptible oxidative injury. Increased amounts ROS can result cellular malfunction, apoptosis neurodegeneration. They represent a substantial mitochondrial dysfunction, defining characteristic Comprehending fundamental mechanisms its interactions with function, neuroinflammation protective pathways becomes essential for formulating targeted therapeutics maintain health reduce impacts We address recent highlights on role function terms significance neuronal

Язык: Английский

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Huangqin decoction attenuates spared nerve injury (SNI)-induced neuropathic pain by modulating microglial M1/M2 polarization partially mediated by intestinal nicotinamide metabolism

Phytomedicine, Год журнала: 2024, Номер 129, С. 155594 - 155594

Опубликована: Апрель 7, 2024

Язык: Английский

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Unlocking Nutraceutical Potential: Metabolomic Analysis Reveals Therapeutic Compounds in Rice

Journal of Pharmacology and Pharmacotherapeutics, Год журнала: 2025, Номер unknown

Опубликована: Янв. 13, 2025

Background Rice varieties enriched with potential bioactive compounds are poised to make a significant contribution global health. It is anticipated that edible medications made from rice seeds will lead novel therapeutics. Purpose High-yielding popular pigmented and nonpigmented were selected for in-depth analysis of contents. Nutraceutical high-yielding often goes underexplored compared low-yielding specialty varieties. This study addresses the gap by metabolomic profiling uncover pharmaceutical nutritional benefits. Methods Untargeted brown was conducted Orbitrap-high-resolution liquid chromatography mass spectrometry, primary secondary metabolites identified annotated. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging (RS) assay carried out identify variety superior antioxidant activity. Correlation using Metaboanalyst software major RS potential. Over-representation performed Kyoto Encyclopedia Genes Genomes (KEGG) pathway enrichment, pathways nutraceutical in rice. Results Major antioxidant, anti-inflammatory, anticarcinogenic properties Bioactive detected included choline, didodecyl-3,3-thiodipropionate, conjugated linoleic acid, oleic 13( S)-HOTrE, monoolein, nicotinic pantothenic isoquinoline, trigonelline, corymboside, ferulic 2,4-quinolinediol. The DPPH revealed activity rice, differential phenylpropanoid biosynthesis, arginine proline metabolism, biosynthesis unsaturated fatty acids showing correlation ( p < .01) Conclusion Catechin, (–)-epicatechin, (±)12(13)-DiHOME, 4-guanidinobutyric 5-methoxysalicylic acid key emphasize red-colored as functional food health highlights therapeutic promise whole-grain

Язык: Английский

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Nicotinamide Adenine Dinucleotide and Parkinson’s Disease

Опубликована: Янв. 1, 2025

Язык: Английский

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Bifidobacterium adolescentis-derived nicotinic acid improves host skeletal muscle mitochondrial function to ameliorate sarcopenia

Cell Reports, Год журнала: 2025, Номер 44(2), С. 115265 - 115265

Опубликована: Фев. 1, 2025

Sarcopenia significantly diminishes quality of life and increases mortality risk in older adults. While the connection between gut microbiome muscle health is recognized, underlying mechanisms are poorly understood. In this study, shotgun metagenomics revealed that Bifidobacterium adolescentis notably depleted individuals with sarcopenia, correlating reduced mass function. This finding was validated aged mice. Metabolomics analysis identified nicotinic acid as a key metabolite produced by B. adolescentis, linked to improvements functionality sarcopenia. Mechanistically, restores nicotinamide adenine dinucleotide (NAD+) levels muscle, inhibits FoxO3/Atrogin-1/Murf-1 axis, promotes satellite cell proliferation, reducing atrophy. Additionally, NAD+ activation enhances silent-information-regulator 1 (SIRT1)/peroxisome-proliferator-activated-receptor-γ-coactivator 1-alpha (PGC-1α) stimulating mitochondrial biogenesis promoting oxidative metabolism slow-twitch fibers, ultimately improving Our findings suggest adolescentis-derived could be promising therapeutic strategy for

Язык: Английский

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Vitamins in the Prevention and Support Therapy of Neurodegenerative Diseases

International Journal of Molecular Sciences, Год журнала: 2025, Номер 26(3), С. 1333 - 1333

Опубликована: Фев. 4, 2025

Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s (PD), amyotrophic lateral sclerosis (ALS), and multiple (MS), which are a consequence of the progressive loss neuronal function structure, cause significant cognitive impairment. The incidence these in world’s population is constantly increasing result an aging population. Although genetic environmental factors most often mentioned pathogenetic diseases, evidence points to important role proper nutrition prevention support treatment disorders. A healthy, balanced diet can mitigate risks associated with risk above slow progression by reducing oxidative stress inflammation. Vitamins B, D, E, C, K, have been shown functions protect nervous system. This review demonstrates importance vitamins preventing supporting therapy neurodegenerative diseases. Information regarding health-promoting properties must be effectively communicated consumers seeking their health, particularly context Consequently, this also examines authorized health claims under EU food law related vitamins, assessing promoting awareness vitamins’ potential benefits for neuroprotection management

Язык: Английский

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Association of dietary niacin intake with osteoporosis in the postmenopausal women in the US: NHANES 2007–2018

Frontiers in Medicine, Год журнала: 2025, Номер 12

Опубликована: Фев. 5, 2025

Background Elderly individuals with inadequate vitamin B level are at increased risk of degenerative conditions, notably cardiovascular disorders, cognitive impairments, and osteoporosis. The relationship between niacin (vitamin B3) consumption osteoporosis remains a subject debate. This study aimed to clarify the dietary intake incidence in postmenopausal women aged ≥50 years. Methods In this study, we gathered details on participants’ bone mineral density, status, intake, several other critical variables. Multivariate logistic regression models were constructed determine association Restricted cubic splines employed further assess linearity explore shape dose-response associations. Additionally, performed stratified interaction analyses illustrate stability observed relationships across different subgroups. Results After adjusting for all covariates, there was significant inverse (OR = 0.87; 95% CI: 0.77–0.97; p 0.016). A negative (nonlinear: 0.672). While revealed some differences risk, these not statistically significant. Conclusion Dietary exhibited an correlation significantly reduced by 13% every 10 mg/day increase daily among women.

Язык: Английский

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