Journal of Applied Polymer Science,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 22, 2024
ABSTRACT
Functionalized
gold
nanoparticles
(GNPs)
are
extensively
utilized
in
various
disciplines
due
to
their
excellent
bioactivity,
biocompatibility,
and
extended
drug
half‐life,
influenced
by
the
ligands
size
that
changed
on
surfaces.
In
this
study,
we
successfully
fabricated
GNPs
coated
with
containing
docosahexaenoic
acid
(DHA)
polyethylene
glycol
(PEG)
clocked
a
carboxyl
group.
These
referred
as
MPA@GNPs‐PEG‐DHA.
The
cytotoxicity
results
demonstrate
MPA@GNPs‐PEG‐DHA
exhibits
superior
cell
selectivity,
explicitly
inhibiting
proliferation
of
breast
cancerous
cells
than
noncancerous
lines.
Apoptosis
is
involved
reduction
MPA@GNPs‐PEG‐DHA,
demonstrated
clearly
through
many
assays
measuring
apoptotic
index,
including
AO/EB
staining,
DAPI,
annexin
V‐FITC
mitochondrial
membrane
potential
(MMP),
reactive
oxygen
species
(ROS)
measurement.
efficacy
inducing
apoptosis
was
its
inhibition
dysfunction
ROS.
has
improve
induction
cells.
Journal of Molecular Liquids,
Год журнала:
2023,
Номер
395, С. 123888 - 123888
Опубликована: Дек. 27, 2023
Efficient
drug
delivery
systems
(DDSs)
play
a
pivotal
role
in
ensuring
pharmaceuticals'
targeted
and
effective
administration.
However,
the
intricate
interplay
between
formulations
poses
challenges
their
design
optimization.
Simulations
have
emerged
as
indispensable
tools
for
comprehending
these
interactions
enhancing
DDS
performance
to
address
this
complexity.
This
comprehensive
review
explores
latest
advancements
simulation
techniques
provides
detailed
analysis.
The
encompasses
various
methodologies,
including
molecular
dynamics
(MD),
Monte
Carlo
(MC),
finite
element
analysis
(FEA),
computational
fluid
(CFD),
density
functional
theory
(DFT),
machine
learning
(ML),
dissipative
particle
(DPD).
These
are
critically
examined
context
of
research.
article
presents
illustrative
case
studies
involving
liposomal,
polymer-based,
nano-particulate,
implantable
DDSs,
demonstrating
influential
simulations
optimizing
systems.
Furthermore,
addresses
advantages
limitations
It
also
identifies
future
directions
research
development,
such
integrating
multiple
techniques,
refining
validating
models
greater
accuracy,
overcoming
limitations,
exploring
applications
personalized
medicine
innovative
DDSs.
employing
like
MD,
MC,
FEA,
CFD,
DFT,
ML,
DPD
offer
crucial
insights
into
behaviour,
aiding
Despite
advantages,
rapid
cost-effective
screening,
require
validation
addressing
limitations.
Future
should
focus
on
models,
enhance
outcomes.
paper
underscores
contribution
emphasizing
providing
valuable
facilitating
development
optimization
ultimately
patient
As
we
continue
explore
impact
advancing
discovery
improving
DDSs
is
expected
be
profound.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
This
review
discusses
the
recent
developments
in
copper-based
nanomaterials
that
utilize
copper-induced
cell
death,
categorized
by
materials
systems,
while
highlighting
limitations
of
current
cuproptosis
related
nanomaterials.
Advanced Materials,
Год журнала:
2024,
Номер
36(21)
Опубликована: Фев. 24, 2024
Engineered
bacteria
are
widely
used
in
cancer
treatment
because
live
facultative/obligate
anaerobes
can
selectively
proliferate
at
tumor
sites
and
reach
hypoxic
regions,
thereby
causing
nutritional
competition,
enhancing
immune
responses,
producing
anticancer
microbial
agents
situ
to
suppress
growth.
Despite
the
unique
advantages
of
bacteria-based
biotherapy,
insufficient
efficiency
limits
its
application
complete
ablation
malignant
tumors.
The
combination
nanomedicine
engineered
has
attracted
increasing
attention
owing
their
striking
synergistic
effects
treatment.
that
function
as
natural
vehicles
effectively
deliver
nanomedicines
sites.
Moreover,
provide
an
opportunity
enhance
by
modulating
TME
substrates
support
nanomedicine-mediated
reactions.
Nanomedicine
exhibits
excellent
optical,
magnetic,
acoustic,
catalytic
properties,
plays
important
role
promoting
bacteria-mediated
biotherapies.
therapy
comprehensively
summarized
this
review.
Attention
is
paid
not
only
fabrication
nanobiohybrid
composites,
but
also
interpromotion
mechanism
between
therapy.
Additionally,
recent
advances
bacteria-synergized
multimodal
therapies
highlighted.
Signal Transduction and Targeted Therapy,
Год журнала:
2024,
Номер
9(1)
Опубликована: Янв. 10, 2024
Abstract
Live
bacteria-mediated
antitumor
therapies
mark
a
pivotal
point
in
cancer
immunotherapy.
However,
the
difficulty
reconciling
safety
and
efficacy
of
bacterial
has
limited
their
application.
Improving
tumor-targeted
delivery
while
maintaining
biosafety
is
critical
hurdle
for
clinical
translation
live
microbial
therapy
cancer.
Here,
we
developed
“dead”
yet
“functional”
Salmonella
-loaded
macrophages
using
liquid
nitrogen
cold
shock
an
attenuated
typhimurium
VNP20009-contained
macrophage
cell
line.
The
obtained
achieve
average
loading
approximately
257
bacteria
per
100
cells.
engineered
cells
maintain
intact
cellular
structure
but
lose
original
pathogenicity,
intracellular
retain
biological
activity
are
delay
freed,
followed
by
proliferation.
This
“Trojan
horse”-like
camouflage
strategy
avoids
immunogenicity-induced
neutrophil
recruitment
activation
peripheral
blood,
reduces
clearance
neutrophils
enhances
tumor
enrichment
efficiently
after
systemic
administration.
Furthermore,
this
also
strongly
activated
microenvironment,
including
increasing
effector
(including
M1-like
CD8+
Teffs)
decreasing
protumor
M2-like
CD4+
Tregs),
ultimately
improved
subcutaneous
H22
tumor-bearing
mouse
model.
cryo-shocked
macrophage-mediated
holds
promise
expanding
therapeutic
applications
living
Pharmaceutics,
Год журнала:
2025,
Номер
17(3), С. 277 - 277
Опубликована: Фев. 20, 2025
Increasing
evidence
shows
that
a
very
small
population
of
cancer
stem
cells
(CSCs)
is
responsible
for
recurrence,
drug
resistance,
and
metastasis.
CSCs
usually
reside
in
hypoxic
tumor
regions
are
characterized
by
high
tumorigenicity.
Their
inaccessible
nature
allows
them
to
avoid
the
effects
conventional
treatments
such
as
chemotherapy,
radiotherapy,
surgery.
In
addition,
chemo-
radiotherapy
potentially
toxic
could
help
spread
survive.
New
therapeutic
targets
against
sought,
including
different
signaling
pathways
distinct
cell
surface
markers.
Recent
advances
nanotechnology
have
provided
hope
development
new
avenues
eradicate
CSCs.
this
review,
we
present
newly
discovered
nanoparticles
can
be
co-loaded
with
an
apoptosis-inducing
agent
or
differentiation-inducing
agent,
stability,
cellular
penetration,
release.
We
also
summarize
molecular
characteristics
their
survival
maintenance.
Controlled
release
targeting
aims
reduce
stemness-related
suppress
growth,
prevent
relapse
metastases.
Journal of Translational Medicine,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июль 2, 2024
Abstract
The
application
of
graphene-based
nanocomposites
for
therapeutic
and
diagnostic
reasons
has
advanced
considerably
in
recent
years
due
to
advancements
the
synthesis
design
nanocomposites,
giving
rise
a
new
field
nano-cancer
diagnosis
treatment.
Nano-graphene
is
being
utilized
more
often
cancer
therapy,
where
it
employed
conjunction
with
diagnostics
treatment
address
complex
clinical
obstacles
problems
associated
this
life-threatening
illness.
When
compared
other
nanomaterials,
graphene
derivatives
stand
out
their
remarkable
structural,
mechanical,
electrical,
optical,
thermal
capabilities.
high
specific
surface
area
these
materials
makes
them
useful
as
carriers
controlled
release
systems
that
respond
external
stimuli;
compounds
include
drugs
biomolecules
like
nucleic
acid
sequences
(DNA
RNA).
Furthermore,
presence
distinctive
sheet-like
nanostructures
capacity
photothermal
conversion
have
rendered
highly
favorable
optical
applications,
including
(PTT),
photodynamic
therapy
(PDT),
theranostics.
This
review
highlights
current
state
benefits
using
discusses
prospects
future
development.
Then
we
focus
on
applications
treatment,
smart
drug
delivery
systems,
PTT,
PDT.
Lastly,
biocompatibility
also
discussed
provide
unique
overview
topic.
