Smart Nano-Hybrid Metal-Organic Frameworks: Revolutionizing Advancements, Applications, and Challenges in Biomedical Therapeutics and Diagnostics

Hybrid Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100406 - 100406

Published: Feb. 1, 2025

Language: Английский

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Polydopamine-Coated Zn-MOF-74 Nanocarriers: Versatile Drug Delivery Systems with Enhanced Biocompatibility and Cancer Therapeutic Efficacy

Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown

Published: July 13, 2024

Language: Английский

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Exploring the synthesis, properties, and potential of chitosan-functionalized metal-organic frameworks in emerging applications

Progress in Materials Science, Journal Year: 2024, Volume and Issue: 148, P. 101387 - 101387

Published: Oct. 9, 2024

Language: Английский

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Metal–Organic Frameworks: Unconventional Nanoweapons against COVID

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(25), P. 32118 - 32127

Published: June 11, 2024

The SARS-CoV-2 (COVID-19) pandemic outbreak led to enormous social and economic repercussions worldwide, felt even this date, making the design of new therapies combat fast-spreading viruses an imperative task. In face this, diverse cutting-edge nanotechnologies have risen as promising tools treat infectious diseases such COVID-19, well challenging illnesses cancer diabetes. Aside from these applications, nanoscale metal-organic frameworks (nanoMOFs) attracted much attention novel efficient drug delivery systems for pathologies. However, their potential anti-COVID-19 therapeutic agents has not been investigated. Herein, we propose a pioneering anti-COVID MOF approach by studying safe intrinsically antiviral through screening various nanoMOF. iron(III)-trimesate MIL-100 showed noteworthy effect against at micromolar range, ensuring high biocompatibility profile (90% viability) in real infected human cellular scenario. This research effectively paves way toward based on nanoMOFs, only but also other and/or pulmonary diseases.

Language: Английский

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Efficacy of a Zn-based metalorganic framework doped with benznidazole on acute experimental Trypanosoma cruzi infection

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Feb. 28, 2024

Metal-Organic Frameworks (MOFs) have are known to enhance the activity of compounds when used as drug carriers due their ability cross cell membrane, allowing for controlled and selective release. In this study, effect BNZ@Zn-MOFs on acute phase infection was evaluated in a mouse model. The particles were obtained by electroelution (EL), doped with BZN mechanochemistry characterized scanning electron microscopy (SEM), infrared spectroscopy (FTIR) X-ray diffraction (XRD). BNZ@Zn-MOF released 80% after 3 h. No cytotoxicity observed NIH-3T3 HeLa cells. Antiparasitic model experimental BALB/c mice, using dose 250 times lower than that required free BZN. PCR analysis showed no parasite DNA tissues treated mice. Hematoxylin-eosin staining revealed apparent damage tissue architecture. Serum levels liver function enzymes remained unchanged. use suboptimal doses delivery system allows maintenance may facilitate significant reduction side effects caused administration treatment Chagas disease.

Language: Английский

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Efficacy of a Zn-based metalorganic framework doped with benznidazole on acute experimental Trypanosoma cruzi infection

Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown

Published: July 7, 2024

Language: Английский

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A versatile method for facile and reliable synthesis of colloidal particles with a size and composition gradient

Colloid & Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

Abstract Colloidal particles play a pivotal role in numerous applications across various disciplines, many of which necessitate precise control over particle size and distribution. Seeded growth reactions have been established as effective methods for reproducibly accessing tailor-made particles. However, conventional batch-wise syntheses only yield discrete sizes. With the increasing focus on complex structures current research, there is demand innovative adaptable techniques to produce colloidal with sizes distributions. The Controlled Emulsion Extraction Process (CrEEP) capable addressing this challenge. Here, we present detail how synthesis works demonstrate its reliability versatility. Our approach exploits time-dependent enables dispersions controlled We highlight these possibilities through variation monomer feed composition, resulting gradual changes both glass transition temperature, respectively. Beyond application polymer particles, CrEEP can be seamlessly extended other seeded-growth mechanisms, such silica Stöber synthesis. Consequently, (CrESP) similarly yields gradient, showcasing generality synthetic advancement. Graphical abstract

Language: Английский

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Hyaluronic acid modified Cu/Mn-doped metal-organic framework nanocatalyst for chemodynamic therapy

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(6), P. 065025 - 065025

Published: Oct. 2, 2024

Chemodynamic therapy (CDT) is a new method for cancer treatment that produces highly toxic reactive oxygen species (ROS) in the tumor microenvironment to induce cell apoptosis or necrosis. However, therapeutic effect of CDT often hindered by intracellular H

Language: Английский

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