Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy

Pharmaceutics, Год журнала: 2024, Номер 16(10), С. 1332 - 1332

Опубликована: Окт. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Язык: Английский

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Metallic nanoparticles unveiled: Synthesis, characterization, and their environmental, medicinal, and agricultural applications

Talanta, Год журнала: 2024, Номер 280, С. 126790 - 126790

Опубликована: Авг. 29, 2024

Язык: Английский

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The effects of nanoparticle based drugs on Helicobacter pylori infection and gastric cancer

Gene Reports, Год журнала: 2025, Номер unknown, С. 102223 - 102223

Опубликована: Апрель 1, 2025

Язык: Английский

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Investigation of the Antioxidant and Cellular Toxicity Activities of Gold Nanoparticles Synthesized Using <i>Cichorium Intybus</i> Extract on a Liver Cancer Cell Line

Deleted Journal, Год журнала: 2025, Номер 24(1)

Опубликована: Апрель 14, 2025

Background: Liver cancer is increasing in different parts of the world and fourth leading cause death globally. Objectives: The present study aims to synthesize analyze characterization gold nanoparticles (AuNPs) synthesized by Cichorium intybus extract evaluate their antioxidant cellular toxicity activity against liver cells (HepG2). Methods: AuNPs were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), fourier-transform infrared spectroscopy (FTIR). was assessed DPPH test, cytotoxicity analyzed MTT method. Results: results indicate that are crystalline materials with a particle size less than 100 nm, mean 23.94 nm. FTIR reveals presence biochemical groups act as reducing factors. demonstrate increases concentration, 87% inhibition free radical scavenging observed at 250 µg/mL. Cell cell lines (HepG2) demonstrated significant time- dose-dependent manner. percentage viability concentration 1000 µg/ml after 24, 48, 72 hours determined be 45%, 51%, 22%, respectively. Conclusions: revealed simple cost-effective environmentally friendly method could employed from food pharmaceutical industries.

Язык: Английский

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Gold Nanoparticle Adsorption and Uptake are Directed by Particle Capping Agent

Small Science, Год журнала: 2025, Номер unknown

Опубликована: Май 19, 2025

Nanomaterials are revolutionizing the development of novel therapies, with applications ranging from drug delivery and diagnostics to controlling specific biological processes. However, interactions that govern nanomaterial behavior in systems remain difficult elucidate due complex dynamic nature lipid bilayer environment. Here, a combination atomic force microscopy molecular dynamics simulations is used discover precise mechanisms by which various ligand‐capped 5 nm gold nanoparticles (AuNPs) interact supported bilayers pure fluid phospholipids (1,2‐di(9Z‐octadecenoyl)‐sn‐glycero‐3‐phosphocholine (DOPC)). When ligand capping agent altered, differences adsorption disruption as function size charge observed. Weakly physiosorbed ligands enable absorption AuNP into bilayer's hydrophobic core, whereas more strongly adsorbed inhibit complete insertion AuNP. ligand‐dependent headgroup can lead interfacial adhesion or inhibition adsorption. These results reveal interaction AuNPs membranes varies depending on agent. Notably, may involve cooperative (or synergistic) effects membrane components, highlighting importance understanding these at resolution.

Язык: Английский

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New Nanoparticle-Based Drug: A 2024 Update and Future Prospects

BioNanoScience, Год журнала: 2025, Номер 15(3)

Опубликована: Май 19, 2025

Язык: Английский

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Site Specific Delivery of Pectin-Stabilized Gold Nanoparticles for Liver: An In-vivo Evaluation with Doxorubicin

Journal of Drug Delivery Science and Technology, Год журнала: 2025, Номер unknown, С. 107118 - 107118

Опубликована: Май 1, 2025

Язык: Английский

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Low-intensity pulsed ultrasound enhances uptake of doxorubicin-loaded gold nanoparticles in cancer cells

Ultrasonics Sonochemistry, Год журнала: 2025, Номер unknown, С. 107417 - 107417

Опубликована: Июнь 1, 2025

Язык: Английский

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Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment

Nanomedicine, Год журнала: 2024, Номер unknown, С. 1 - 23

Опубликована: Май 9, 2024

To establish a methodology for understanding how ultrasound (US) induces drug release from nano-sized drug-delivery systems (NSDDSs) and enhances penetration uptake in tumors. This aims to advance cancer treatment strategies.

Язык: Английский

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Polyvinyl Alcohol (PVA)-Based Stimuli-Sensitive Hydrogel Containing Carbon Nanotube (CNT) and Polyethylene Glycol (PEG)

Arabian Journal for Science and Engineering, Год журнала: 2024, Номер unknown

Опубликована: Сен. 11, 2024

Язык: Английский

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