Gold-Coated Phage Nanosomes For Ultrasound Mediated Breast Cancer Therapeutics DOI
Dokkari Nagalaxmi Yadav,

Sunil Venkanna Pogu,

Sri Amruthaa Sankaranarayanan

et al.

Published: March 27, 2024

Ultrasound has been an excellent tool for various disease diagnoses over the last few decades. Due to its noninvasive properties, FDA approved it therapeutic application in multiple diseases, leading new avenues precise drug delivery. Over decade, different organic and inorganic ultrasound-sensitive nanoparticles have developed theranostic applications. The present study reports synthesis of novel phage-based gold-coated nanosomes ultrasound-mediated cancer therapeutics. synthesized were evaluated their size morphology, ultrasound sensitivity. Nanosomes under trigger released mitoxantrone generated significant ROS 4T1 cells, which resulted mitochondrial damage cellular apoptosis, eventually causing cell death. In summary, found be potent ultrasound-responsive materials

Language: Английский

Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy DOI Creative Commons

Joel Georgeous,

Nour AlSawaftah, Waad H. Abuwatfa

et al.

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1332 - 1332

Published: Oct. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Language: Английский

Citations

24

Metallic nanoparticles unveiled: Synthesis, characterization, and their environmental, medicinal, and agricultural applications DOI
Mohammad Tahir Aminzai, Metin Yıldırım, Erdal Yabalak

et al.

Talanta, Journal Year: 2024, Volume and Issue: 280, P. 126790 - 126790

Published: Aug. 29, 2024

Language: Английский

Citations

17

The effects of nanoparticle based drugs on Helicobacter pylori infection and gastric cancer DOI
Zahra Ebrahimi, H Hamid, Parisa Salari

et al.

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102223 - 102223

Published: April 1, 2025

Language: Английский

Citations

0

Investigation of the Antioxidant and Cellular Toxicity Activities of Gold Nanoparticles Synthesized Using <i>Cichorium Intybus</i> Extract on a Liver Cancer Cell Line DOI Creative Commons

Mohammad Mohammad-Alizadeh,

Ahmad Asgharzadeh, Maryam Tatari

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 14, 2025

Background: Liver cancer is increasing in different parts of the world and fourth leading cause death globally. Objectives: The present study aims to synthesize analyze characterization gold nanoparticles (AuNPs) synthesized by Cichorium intybus extract evaluate their antioxidant cellular toxicity activity against liver cells (HepG2). Methods: AuNPs were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), fourier-transform infrared spectroscopy (FTIR). was assessed DPPH test, cytotoxicity analyzed MTT method. Results: results indicate that are crystalline materials with a particle size less than 100 nm, mean 23.94 nm. FTIR reveals presence biochemical groups act as reducing factors. demonstrate increases concentration, 87% inhibition free radical scavenging observed at 250 µg/mL. Cell cell lines (HepG2) demonstrated significant time- dose-dependent manner. percentage viability concentration 1000 µg/ml after 24, 48, 72 hours determined be 45%, 51%, 22%, respectively. Conclusions: revealed simple cost-effective environmentally friendly method could employed from food pharmaceutical industries.

Language: Английский

Citations

0

Gold Nanoparticle Adsorption and Uptake are Directed by Particle Capping Agent DOI Creative Commons
Rashad Kariuki,

Rowan Penman,

Alexander D. Newbold

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Nanomaterials are revolutionizing the development of novel therapies, with applications ranging from drug delivery and diagnostics to controlling specific biological processes. However, interactions that govern nanomaterial behavior in systems remain difficult elucidate due complex dynamic nature lipid bilayer environment. Here, a combination atomic force microscopy molecular dynamics simulations is used discover precise mechanisms by which various ligand‐capped 5 nm gold nanoparticles (AuNPs) interact supported bilayers pure fluid phospholipids (1,2‐di(9Z‐octadecenoyl)‐sn‐glycero‐3‐phosphocholine (DOPC)). When ligand capping agent altered, differences adsorption disruption as function size charge observed. Weakly physiosorbed ligands enable absorption AuNP into bilayer's hydrophobic core, whereas more strongly adsorbed inhibit complete insertion AuNP. ligand‐dependent headgroup can lead interfacial adhesion or inhibition adsorption. These results reveal interaction AuNPs membranes varies depending on agent. Notably, may involve cooperative (or synergistic) effects membrane components, highlighting importance understanding these at resolution.

Language: Английский

Citations

0

New Nanoparticle-Based Drug: A 2024 Update and Future Prospects DOI
Hannah R. Martin, Horacio Bach

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(3)

Published: May 19, 2025

Language: Английский

Citations

0

Site Specific Delivery of Pectin-Stabilized Gold Nanoparticles for Liver: An In-vivo Evaluation with Doxorubicin DOI
Mayank K. Singh,

Susanne Schulte,

Rohith Kumar

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 107118 - 107118

Published: May 1, 2025

Language: Английский

Citations

0

Low-intensity pulsed ultrasound enhances uptake of doxorubicin-loaded gold nanoparticles in cancer cells DOI Creative Commons
Farshad Moradi Kashkooli, Anshuman Jakhmola, Graham A. Ferrier

et al.

Ultrasonics Sonochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 107417 - 107417

Published: June 1, 2025

Language: Английский

Citations

0

Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment DOI
Farshad Moradi Kashkooli, Anshuman Jakhmola, Graham A. Ferrier

et al.

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: May 9, 2024

To establish a methodology for understanding how ultrasound (US) induces drug release from nano-sized drug-delivery systems (NSDDSs) and enhances penetration uptake in tumors. This aims to advance cancer treatment strategies.

Language: Английский

Citations

2

Polyvinyl Alcohol (PVA)-Based Stimuli-Sensitive Hydrogel Containing Carbon Nanotube (CNT) and Polyethylene Glycol (PEG) DOI

Şule Balcı,

Yağmur Camcı, Serbülent Türk

et al.

Arabian Journal for Science and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Language: Английский

Citations

1