Review of Gold Nanoparticles: Synthesis, Properties, Shapes, Cellular Uptake, Targeting, Release Mechanisms and Applications in Drug Delivery and Therapy

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(10), P. 1332 - 1332

Published: Oct. 16, 2024

The remarkable versatility of gold nanoparticles (AuNPs) makes them innovative agents across various fields, including drug delivery, biosensing, catalysis, bioimaging, and vaccine development. This paper provides a detailed review the important role AuNPs in delivery therapeutics. We begin by exploring traditional systems (DDS), highlighting revolutionizing techniques. then describe unique intriguing properties that make exceptional for delivery. Their shapes, functionalization, drug-loading bonds, targeting mechanisms, release therapeutic effects, cellular uptake methods are discussed, along with relevant examples from literature. Lastly, we present applications medical domains, cancer, cardiovascular diseases, ocular diabetes, focus on vitro vivo cancer research.

Language: Английский

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Metallic nanoparticles unveiled: Synthesis, characterization, and their environmental, medicinal, and agricultural applications

Talanta, Journal Year: 2024, Volume and Issue: 280, P. 126790 - 126790

Published: Aug. 29, 2024

Language: Английский

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The effects of nanoparticle based drugs on Helicobacter pylori infection and gastric cancer

Gene Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102223 - 102223

Published: April 1, 2025

Language: Английский

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Investigation of the Antioxidant and Cellular Toxicity Activities of Gold Nanoparticles Synthesized Using <i>Cichorium Intybus</i> Extract on a Liver Cancer Cell Line

Deleted Journal, Journal Year: 2025, Volume and Issue: 24(1)

Published: April 14, 2025

Background: Liver cancer is increasing in different parts of the world and fourth leading cause death globally. Objectives: The present study aims to synthesize analyze characterization gold nanoparticles (AuNPs) synthesized by Cichorium intybus extract evaluate their antioxidant cellular toxicity activity against liver cells (HepG2). Methods: AuNPs were characterized using X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), fourier-transform infrared spectroscopy (FTIR). was assessed DPPH test, cytotoxicity analyzed MTT method. Results: results indicate that are crystalline materials with a particle size less than 100 nm, mean 23.94 nm. FTIR reveals presence biochemical groups act as reducing factors. demonstrate increases concentration, 87% inhibition free radical scavenging observed at 250 µg/mL. Cell cell lines (HepG2) demonstrated significant time- dose-dependent manner. percentage viability concentration 1000 µg/ml after 24, 48, 72 hours determined be 45%, 51%, 22%, respectively. Conclusions: revealed simple cost-effective environmentally friendly method could employed from food pharmaceutical industries.

Language: Английский

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Development of an ultrasound-mediated nano-sized drug-delivery system for cancer treatment: from theory to experiment

Nanomedicine, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 23

Published: May 9, 2024

To establish a methodology for understanding how ultrasound (US) induces drug release from nano-sized drug-delivery systems (NSDDSs) and enhances penetration uptake in tumors. This aims to advance cancer treatment strategies.

Language: Английский

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Polyvinyl Alcohol (PVA)-Based Stimuli-Sensitive Hydrogel Containing Carbon Nanotube (CNT) and Polyethylene Glycol (PEG)

Arabian Journal for Science and Engineering, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 11, 2024

Language: Английский

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Gold-Coated Phage Nanosomes For Ultrasound Mediated Breast Cancer Therapeutics

Published: March 27, 2024

Ultrasound has been an excellent tool for various disease diagnoses over the last few decades. Due to its noninvasive properties, FDA approved it therapeutic application in multiple diseases, leading new avenues precise drug delivery. Over decade, different organic and inorganic ultrasound-sensitive nanoparticles have developed theranostic applications. The present study reports synthesis of novel phage-based gold-coated nanosomes ultrasound-mediated cancer therapeutics. synthesized were evaluated their size morphology, ultrasound sensitivity. Nanosomes under trigger released mitoxantrone generated significant ROS 4T1 cells, which resulted mitochondrial damage cellular apoptosis, eventually causing cell death. In summary, found be potent ultrasound-responsive materials

Language: Английский

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Polyvinyl alcohol assisted citrate based reduction of gold(III) ions: Theoretical design and experimental study on green synthesis of spherical and biocompatible gold nanoparticles

Materials Today Sustainability, Journal Year: 2024, Volume and Issue: unknown, P. 101012 - 101012

Published: Oct. 1, 2024

Language: Английский

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Biosynthesized nanoparticles in pharmaceutical and biomedical sciences: recent advances

Materials Today Communications, Journal Year: 2024, Volume and Issue: 41, P. 110741 - 110741

Published: Oct. 18, 2024

Language: Английский

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Medical nanoscale materials for virus-induced cervical cancer therapeutic modalities: For targeting delivery

OpenNano, Journal Year: 2024, Volume and Issue: 21, P. 100221 - 100221

Published: Nov. 18, 2024

Language: Английский

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