Ultrasound
has
been
an
excellent
tool
for
various
disease
diagnoses
over
the
last
few
decades.
Due
to
its
noninvasive
properties,
FDA
approved
it
therapeutic
application
in
multiple
diseases,
leading
new
avenues
precise
drug
delivery.
Over
decade,
different
organic
and
inorganic
ultrasound-sensitive
nanoparticles
have
developed
theranostic
applications.
The
present
study
reports
synthesis
of
novel
phage-based
gold-coated
nanosomes
ultrasound-mediated
cancer
therapeutics.
synthesized
were
evaluated
their
size
morphology,
ultrasound
sensitivity.
Nanosomes
under
trigger
released
mitoxantrone
generated
significant
ROS
4T1
cells,
which
resulted
mitochondrial
damage
cellular
apoptosis,
eventually
causing
cell
death.
In
summary,
found
be
potent
ultrasound-responsive
materials
Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
16(10), P. 1332 - 1332
Published: Oct. 16, 2024
The
remarkable
versatility
of
gold
nanoparticles
(AuNPs)
makes
them
innovative
agents
across
various
fields,
including
drug
delivery,
biosensing,
catalysis,
bioimaging,
and
vaccine
development.
This
paper
provides
a
detailed
review
the
important
role
AuNPs
in
delivery
therapeutics.
We
begin
by
exploring
traditional
systems
(DDS),
highlighting
revolutionizing
techniques.
then
describe
unique
intriguing
properties
that
make
exceptional
for
delivery.
Their
shapes,
functionalization,
drug-loading
bonds,
targeting
mechanisms,
release
therapeutic
effects,
cellular
uptake
methods
are
discussed,
along
with
relevant
examples
from
literature.
Lastly,
we
present
applications
medical
domains,
cancer,
cardiovascular
diseases,
ocular
diabetes,
focus
on
vitro
vivo
cancer
research.
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: April 14, 2025
Background:
Liver
cancer
is
increasing
in
different
parts
of
the
world
and
fourth
leading
cause
death
globally.
Objectives:
The
present
study
aims
to
synthesize
analyze
characterization
gold
nanoparticles
(AuNPs)
synthesized
by
Cichorium
intybus
extract
evaluate
their
antioxidant
cellular
toxicity
activity
against
liver
cells
(HepG2).
Methods:
AuNPs
were
characterized
using
X-ray
diffraction
(XRD),
field
emission
scanning
electron
microscopy
(FESEM),
fourier-transform
infrared
spectroscopy
(FTIR).
was
assessed
DPPH
test,
cytotoxicity
analyzed
MTT
method.
Results:
results
indicate
that
are
crystalline
materials
with
a
particle
size
less
than
100
nm,
mean
23.94
nm.
FTIR
reveals
presence
biochemical
groups
act
as
reducing
factors.
demonstrate
increases
concentration,
87%
inhibition
free
radical
scavenging
observed
at
250
µg/mL.
Cell
cell
lines
(HepG2)
demonstrated
significant
time-
dose-dependent
manner.
percentage
viability
concentration
1000
µg/ml
after
24,
48,
72
hours
determined
be
45%,
51%,
22%,
respectively.
Conclusions:
revealed
simple
cost-effective
environmentally
friendly
method
could
employed
from
food
pharmaceutical
industries.
Small Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
Nanomaterials
are
revolutionizing
the
development
of
novel
therapies,
with
applications
ranging
from
drug
delivery
and
diagnostics
to
controlling
specific
biological
processes.
However,
interactions
that
govern
nanomaterial
behavior
in
systems
remain
difficult
elucidate
due
complex
dynamic
nature
lipid
bilayer
environment.
Here,
a
combination
atomic
force
microscopy
molecular
dynamics
simulations
is
used
discover
precise
mechanisms
by
which
various
ligand‐capped
5
nm
gold
nanoparticles
(AuNPs)
interact
supported
bilayers
pure
fluid
phospholipids
(1,2‐di(9Z‐octadecenoyl)‐sn‐glycero‐3‐phosphocholine
(DOPC)).
When
ligand
capping
agent
altered,
differences
adsorption
disruption
as
function
size
charge
observed.
Weakly
physiosorbed
ligands
enable
absorption
AuNP
into
bilayer's
hydrophobic
core,
whereas
more
strongly
adsorbed
inhibit
complete
insertion
AuNP.
ligand‐dependent
headgroup
can
lead
interfacial
adhesion
or
inhibition
adsorption.
These
results
reveal
interaction
AuNPs
membranes
varies
depending
on
agent.
Notably,
may
involve
cooperative
(or
synergistic)
effects
membrane
components,
highlighting
importance
understanding
these
at
resolution.
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
unknown, P. 1 - 23
Published: May 9, 2024
To
establish
a
methodology
for
understanding
how
ultrasound
(US)
induces
drug
release
from
nano-sized
drug-delivery
systems
(NSDDSs)
and
enhances
penetration
uptake
in
tumors.
This
aims
to
advance
cancer
treatment
strategies.
