Evaluation of the Biological Effect of a Nicotinamide-Containing Broad-Spectrum Sunscreen on Photodamaged Skin DOI Creative Commons

T. Torres-Moral,

Gemma Tell‐Martí, Jaume Bagué

и другие.

Dermatology and Therapy, Год журнала: 2024, Номер 14(12), С. 3321 - 3336

Опубликована: Ноя. 7, 2024

UVA-UVB increases skin matrix metalloproteinases and breaks down extracellular proteins fibrillar type 1 collagen, leading to photodamage. Topical application of nicotinamide prevents UV-induced immunosuppression. Several studies have demonstrated the importance protection against UV. This study aims determine biological effect a high broad-spectrum UVB-UVA sunscreen containing panthenol (SSNP) on photodamaged using linear confocal optical coherence tomography (LC-OCT), immunohistochemistry, RNA profiling. Two areas severely forearm (L01 L02) one less sun-damaged (naturally protected) area inner part (L03) were identified in 14 subjects. These imaged LC-OCT L01 L03 biopsied at baseline. After 4 weeks treatment with SSNP, L02 was reimaged LC-OCT, biopsied. Histology, immunostaining p21, p53, PCNA, CPD, sequencing performed all samples. analysis showed that epidermis thickness number keratinocytes is higher sun-exposed than non-exposed areas. Comparing before after treatment, even though there trend towards normalization, differences not statistically significant. The expression CPD increased compared less-damaged skin. When comparing only p21 decrease expression. 1552 significant genes correlating progression from non-visibly post-treatment pre-treatment samples; pre- samples, 5429 found be significantly associated. A total 1115 are common these two analyses. Additionally, nine first eight second related collagen. Six collagen MAPK cGMP-PKG signalling pathways upregulated photodamage analysis. In analysis, 32 downregulated most being ErbB, Hippo, NOD-like receptor, TNF, NF-kB pathways. demonstrates role SSNP generation, highlights relevance photodamage, shows ability downregulate activated by UV exposure. it deepens our understanding immune-related focuses damage sun exposure can do skin, also called mainly caused ultraviolet radiation, which lead problems such as wrinkles, changes color, sagging Nicotinamide, form vitamin B3, helps cells repair their DNA them dying. Previous mice shown protect immune system reduce risk cancer. order understand how affects an international team researchers gathered Catalan participants examined We conducted imaging, molecular, genetic experiments use. results show thicker contains more keratinocytes. certain indicators active Genetic analyses reveal process causes Using leads positive several cellular processes, including way divide, respond stress, produce summary, this gives us deeper underlines potential benefits adding sunscreens, could promising radiation.

Язык: Английский

Revolutionizing Cosmetic Ingredients: Harnessing the Power of Antioxidants, Probiotics, Plant Extracts, and Peptides in Personal and Skin Care Products DOI Creative Commons

Hye Yung Choi,

Yun Jung Lee, Chul Min Kim

и другие.

Cosmetics, Год журнала: 2024, Номер 11(5), С. 157 - 157

Опубликована: Сен. 12, 2024

The burgeoning interest in natural components personal care products has led to significant research and development of ingredients such as plant extracts, antioxidants, peptides, probiotics. These have been recognized for their potential enhance skin health through various mechanisms, addressing consumer demand that are both effective benign. Plant known rich composition bioactive compounds, offer a myriad benefits including antioxidant, anti-inflammatory, antimicrobial properties, making them invaluable formulations. Antioxidants, derived from plants other sources, play pivotal role protecting the oxidative damage, thereby preventing premature aging promoting vitality. Bioactive peptides garnered attention owing multifunctional activities include collagen synthesis, inhibiting enzymes responsible degradation, reducing inflammation, contributing regeneration anti-aging. Probiotics expanded utility beyond gut care, where they help maintaining microbiome balance, thus enhancing barrier function potentially mitigating disorders. purpose this review is explore individual roles probiotics products, while emphasizing synergistic effects when combined. By integrating these components, paper aims highlight developing innovative skincare formulations not only address specific concerns but also contribute overall health, aligning with increasing preference holistic solutions.

Язык: Английский

Процитировано

7
Niacinamide and its impact on stratum corneum hydration and structure DOI Creative Commons
Thomas Sjöberg,

Andebrhan Fsahaye,

Emelie J. Nilsson

и другие.

Scientific Reports, Год журнала: 2025, Номер 15(1)

Опубликована: Фев. 10, 2025

Abstract Niacinamide (NIA) is widely used in skincare for its favorable safety profile, anti-aging effects, and proven clinical efficacy treating various skin conditions. However, direct impact on the hydration molecular organization of stratum corneum (SC), primary barrier, remains unclear. This study examines how NIA influences SC’s lipid matrix organization, soft keratin structure, water sorption behavior across varying relative humidity (RH) levels. Using small- wide-angle X-ray diffraction dynamic vapor measurements, we compared NIA-treated SC samples to untreated controls under different RHs. The main findings show that while non-hygroscopic, it enhances uptake at high (95% RH). At low (60% RH), swells monomer spacing, although content low, suggesting a plasticizing effect could increase flexibility dry also modifies intensities from differently 60% 95% RH, implying interacts with distribution within protein domains. These effects appear independent investigated dose regime, indicating specific concentration threshold. Overall, shows distinct interaction keratin, swelling spacing between monomers conditions, without acting as traditional keratolytic agent.

Язык: Английский

Процитировано

0
Whole-Genome Structural Variations Study in a Severe Acne Family DOI
Jiaqi Feng, Mingmin Xu,

Jue Qi

и другие.

Journal of Investigative Dermatology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Metabolomic profiles of body shapes and their associations with the risk of incident cardiovascular disease in Chinese adults DOI

Rundong Niu,

Hao Wang, Gaokun Qiu

и другие.

Nutrition Metabolism and Cardiovascular Diseases, Год журнала: 2025, Номер unknown, С. 104031 - 104031

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0
Pilot Clinical Safety and Efficacy Evaluation of a Topical 3% Tranexamic Acid Cream and Serum Protocol for Managing Facial Hyperpigmentation in Caucasian Patients DOI Creative Commons

Sarah Hsin,

Kelly Lourenço,

Alexandre Porcello

и другие.

Cosmetics, Год журнала: 2024, Номер 11(5), С. 168 - 168

Опубликована: Сен. 28, 2024

Facial hyperpigmentation is a highly prevalent dermatological condition, characterized by dark spots on the skin resulting from excess melanin production. Hyperpigmentation significantly impacts patients’ quality of life and self-esteem. Current treatments often present disadvantages linked to poor product tolerability. A topical cosmetic approach combining three lightening active ingredients (tranexamic acid, niacinamide, vitamin C) offers new option for treating skin. The in-use test under control evaluated clinical safety efficacy cream serum containing these ingredients, formulated with hyaluronic acid enhanced delivery, stability, efficacy. total 22 Caucasian patients facial hyperpigmentation, both male female, aged between 45 67 years, applied 8 weeks. Clinical assessments, colorimetric evaluations, standardized photography, self-assessment questionnaires were used measure outcomes. No serious adverse effects recorded, incidence local was low, highlighting good tolerability investigated items. In most participants, significant improvements in hyperpigmented areas recorded. scoring dermatologist investigator indicated statistically 13% reduction color intensity 6% size after weeks treatment. Colorimetric evaluation showed 1% increase luminosity (L* parameter) an 8% improvement Individual Typological Angle (ITA°) endpoint, indicating lighter spots. Subjective assessments reflected high user satisfaction, 95% participants noting hydration luminosity, 77% reporting reduced appearance Overall, work supports use tranexamic C as effective well-tolerated combined management hyperpigmentation. This combination viable alternative classical whiteners individuals seeking reduce coloration imbalance improve tone.

Язык: Английский

Процитировано

0
Evaluation of the Biological Effect of a Nicotinamide-Containing Broad-Spectrum Sunscreen on Photodamaged Skin DOI Creative Commons

T. Torres-Moral,

Gemma Tell‐Martí, Jaume Bagué

и другие.

Dermatology and Therapy, Год журнала: 2024, Номер 14(12), С. 3321 - 3336

Опубликована: Ноя. 7, 2024

UVA-UVB increases skin matrix metalloproteinases and breaks down extracellular proteins fibrillar type 1 collagen, leading to photodamage. Topical application of nicotinamide prevents UV-induced immunosuppression. Several studies have demonstrated the importance protection against UV. This study aims determine biological effect a high broad-spectrum UVB-UVA sunscreen containing panthenol (SSNP) on photodamaged using linear confocal optical coherence tomography (LC-OCT), immunohistochemistry, RNA profiling. Two areas severely forearm (L01 L02) one less sun-damaged (naturally protected) area inner part (L03) were identified in 14 subjects. These imaged LC-OCT L01 L03 biopsied at baseline. After 4 weeks treatment with SSNP, L02 was reimaged LC-OCT, biopsied. Histology, immunostaining p21, p53, PCNA, CPD, sequencing performed all samples. analysis showed that epidermis thickness number keratinocytes is higher sun-exposed than non-exposed areas. Comparing before after treatment, even though there trend towards normalization, differences not statistically significant. The expression CPD increased compared less-damaged skin. When comparing only p21 decrease expression. 1552 significant genes correlating progression from non-visibly post-treatment pre-treatment samples; pre- samples, 5429 found be significantly associated. A total 1115 are common these two analyses. Additionally, nine first eight second related collagen. Six collagen MAPK cGMP-PKG signalling pathways upregulated photodamage analysis. In analysis, 32 downregulated most being ErbB, Hippo, NOD-like receptor, TNF, NF-kB pathways. demonstrates role SSNP generation, highlights relevance photodamage, shows ability downregulate activated by UV exposure. it deepens our understanding immune-related focuses damage sun exposure can do skin, also called mainly caused ultraviolet radiation, which lead problems such as wrinkles, changes color, sagging Nicotinamide, form vitamin B3, helps cells repair their DNA them dying. Previous mice shown protect immune system reduce risk cancer. order understand how affects an international team researchers gathered Catalan participants examined We conducted imaging, molecular, genetic experiments use. results show thicker contains more keratinocytes. certain indicators active Genetic analyses reveal process causes Using leads positive several cellular processes, including way divide, respond stress, produce summary, this gives us deeper underlines potential benefits adding sunscreens, could promising radiation.

Язык: Английский

Процитировано

0