Molecules,
Год журнала:
2024,
Номер
29(24), С. 6044 - 6044
Опубликована: Дек. 22, 2024
Glioblastoma
(GBM)
is
the
most
common
and
aggressive
form
of
brain
cancer
in
adults,
characterized
by
extensive
growth,
a
high
recurrence
rate,
resistance
to
treatment.
Growing
research
interest
focusing
on
biological
roles
natural
compounds
due
their
potential
beneficial
effects
health.
Our
aimed
investigate
lavender
essential
oil
(LEO)
GBM
cell
model.
Chemical
characterization
using
GC-MS
analysis
indicated
that
LEO
contains
several
terpenes,
have
been
found
exhibit
anticancer
properties
interfering
with
key
cancer-related
pathways
models.
By
means
biology
assays,
we
demonstrated
impairs
proliferation
migration,
also
reduces
oxidative
stress
U87
cells.
We
further
observed
Terpinen-4-ol,
contained
LEO,
was
capable
reproducing
results
suggest
terpenic
molecules
present
could
be
considered
valuable
allies
alongside
conventional
therapies
against
GBM.
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101626 - 101626
Опубликована: Март 1, 2025
Cancer
treatment
is
challenged
by
the
tumor
microenvironment
(TME),
which
promotes
drug
resistance
and
cancer
cell
growth.
This
review
offers
a
comprehensive
innovative
perspective
on
how
nanomedicine
can
modify
TME
to
enhance
therapy.
Strategies
include
using
nanoparticles
improve
oxygenation,
adjust
acidity,
alter
extracellular
matrix,
making
treatments
more
effective.
Additionally,
immune
responses
activating
cells
reducing
suppression
within
tumors.
By
integrating
these
approaches
with
existing
therapies,
such
as
chemotherapy
radiotherapy,
show
promise
in
overcoming
traditional
barriers.
The
discusses
changes
effectiveness
of
itself,
creating
reciprocal
relationship
that
boosts
overall
efficacy.
We
also
highlight
novel
strategies
aimed
at
exploiting
TME,
leveraging
nanoparticle-based
for
targeted
therapy
through
precise
modulation.
Nanomaterials,
Год журнала:
2024,
Номер
14(20), С. 1618 - 1618
Опубликована: Окт. 10, 2024
Silver
nanoparticles
(NPs)
have
become
highly
promising
agents
in
the
field
of
biomedical
science,
offering
wide
therapeutic
potential
due
to
their
unique
physicochemical
properties.
The
characteristics
silver
NPs,
such
as
higher
surface-area-to-volume
ratio,
make
them
ideal
for
a
variety
biological
applications.
They
are
easily
processed
thanks
large
surface
area,
strong
plasmon
resonance
(SPR),
stable
nature,
and
multifunctionality.
With
an
emphasis
on
mechanisms
action,
efficacy,
prospective
advantages
this
review
attempts
give
thorough
overview
numerous
applications
these
particles.
utilization
NPs
diagnostics,
bioimaging
biosensing,
well
functions
interventions
antimicrobial
therapies,
cancer
therapy,
diabetes
treatment,
bone
repair,
wound
healing,
investigated.
underlying
processes
by
which
exercise
effects,
oxidative
stress
induction,
apoptosis,
microbial
cell
membrane
rupture,
explored.
Furthermore,
toxicological
concerns
regulatory
issues
discussed,
present
difficulties
restrictions
related
application
medicine.
Hepatocellular
carcinoma
(HCC)
is
one
of
the
most
prevalent
cancers,
characterized
by
high
morbidity
and
mortality
rates.
Recently,
immunotherapy
has
emerged
as
a
crucial
treatment
modality
for
HCC,
following
surgery,
locoregional
therapies,
targeted
therapies.
This
approach
harnesses
body's
immune
system
to
target
eliminate
cancer
cells,
potentially
resulting
in
durable
antitumor
responses.
However,
acquired
resistance
tumor
immunosuppressive
microenvironment
(TIME)
significantly
hinder
its
clinical
application.
advancements
nanotechnology,
coupled
with
deeper
understanding
biology
nano-biological
interactions,
have
led
development
various
nanoparticles
aimed
at
enhancing
therapeutic
efficacy
through
specific
targeting
tissues.
These
increase
accumulation
immunotherapeutic
drugs
within
microenvironment,
thereby
transforming
TIME.
In
this
review,
we
provide
concise
overview
fundamental
principles
governing
TIME
landscape
HCC
discuss
rationale
applications
context.
Additionally,
highlight
existing
challenges
potential
opportunities
translation
nanomedicines.
International Journal of Nanomedicine,
Год журнала:
2025,
Номер
Volume 20, С. 2133 - 2161
Опубликована: Фев. 1, 2025
The
development
of
effective
drug
delivery
systems
is
a
key
focus
in
pharmaceutical
research,
aiming
to
enhance
therapeutic
efficacy
while
minimizing
adverse
effects.
Self-assembled
nanostructures
present
promising
solution
due
their
tunable
properties,
biocompatibility,
and
ability
encapsulate
deliver
agents
specific
targets.
This
review
examines
recent
advancements
drug-based
self-assembled
for
targeted
applications,
including
drug-drug
conjugates,
polymeric-based
architectures,
biomolecules,
peptides,
DNA,
squalene
conjugates
amphiphilic
drugs.
Various
strategies
fabricating
these
are
discussed,
with
an
emphasis
on
the
design
principles
mechanisms
underlying
self-assembly
potential
tissues
or
cells.
Furthermore,
integration
targeting
ligands,
stimuli-responsive
moieties
imaging
into
explored
enhanced
outcomes
real-time
monitoring.
Challenges
such
as
stability,
scalability
regulatory
hurdles
translating
from
bench
bedside
also
addressed.
Drug-based
represent
platform
developing
next-generation
improved
reduced
side
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(4), С. 1752 - 1752
Опубликована: Фев. 19, 2025
Hypoxia-inducible
factors
(HIFs)
are
master
regulators
of
cellular
responses
to
low
oxygen
levels
and
modulate
autophagy,
a
conserved
process
essential
for
maintaining
homeostasis.
Under
hypoxic
conditions,
HIFs
regulate
the
expression
autophagy-related
genes
influence
autophagic
flux
stress
responses.
Dysregulated
hypoxia-induced
autophagy
promotes
cancer
cell
survival,
metabolism,
metastasis,
thereby
contributing
treatment
resistance.
Targeting
HIF-mediated
pathways
or
modulating
processes
offers
potential
improve
traditional
therapies
overcome
drug
Pharmacological
inhibitors
either
alone
in
combination
with
other
treatments,
may
disrupt
pro-survival
mechanisms
within
tumor
microenvironment.
Further
research
is
needed
elucidate
intricate
interplay
between
HIF
signaling
machinery
cells.
Understanding
these
could
pave
way
novel
therapeutic
strategies
enhance
outcomes
combat
This
review
highlights
complex
relationship
development
therapy,
offering
insights
into
how
targeting
patient
outcomes.
Drug Development and Industrial Pharmacy,
Год журнала:
2025,
Номер
unknown, С. 1 - 31
Опубликована: Март 21, 2025
This
review
examines
recent
advancements
in
nanoparticle-based
delivery
systems
for
phytochemicals,
focusing
on
their
role
overcoming
multidrug
resistance,
improving
therapeutic
efficacy,
and
facilitating
clinical
translation.
highlights
advances
nanoparticle-enabled
phytochemical
to
enhance
bioavailability,
improve
outcomes,
enable
targeted
applications.
By
comparing
various
nanoparticle
systems,
formulation
methods,
efficacy
data,
it
identifies
gaps
current
research
guides
the
development
of
more
effective,
next-generation
phytochemical-loaded
nanocarriers.
A
systematic
literature
published
between
2000
2024
was
conducted
using
PubMed,
Scopus,
Web
Science.
Articles
cancer
therapy
were
included.
Compounds
such
as
curcumin,
resveratrol,
quercetin,
epigallocatechin
gallate
demonstrate
enhanced
anti-cancer
when
encapsulated
nanoparticles,
leading
improved
increased
tumor
cell
targeting,
reduced
toxicity.
Clinical
trials
indicate
regression
fewer
adverse
effects.
Emerging
approaches-such
nanogels,
hybrid
combination
therapies
with
immune
checkpoint
inhibitors-further
refine
treatment
efficacy.
Nanoparticle-based
significantly
potential
making
them
promising
candidates
safer,
effective
treatments.
However,
challenges
related
regulatory
guidelines,
scalability,
long-term
safety
must
be
addressed
fully
realize
potential.
ABSTRACT
Background
In
recent
decades,
natural
compounds
have
been
considered
a
significant
source
of
new
antitumor
medicines
due
to
their
unique
advantages.
Several
in
vitro
and
vivo
studies
focused
on
the
effect
terpenoids
apoptosis
mediated
by
mitochondria
malignant
cells.
Recent
findings
this
review
article,
we
six
extensively
studied
terpenoids,
including
sesquiterpenes
(dihydroartemisinin
parthenolide),
diterpenes
(oridonin
triptolide),
triterpenes
(betulinic
acid
oleanolic
acid),
efficacy
targeting
induce
cell
death.
Terpenoid‐induced
mitochondria‐related
death
includes
apoptosis,
pyroptosis,
necroptosis,
ferroptosis,
autophagy,
necrosis
caused
mitochondrial
permeability
transition.
Apoptosis
autophagy
interact
meaningful
ways.
addition,
view
several
disadvantages
such
as
low
stability
bioavailability,
advances
research
combination
chemotherapy
chemical
modification
were
surveyed.
Conclusion
This
article
deepens
our
understanding
association
between
death,
presenting
hypothetical
basis
for
use
anticancer
management.
