Unveiling anticancer, antimicrobial, and antioxidant activities of novel synthesized bimetallic boron oxide–zinc oxide nanoparticles DOI Creative Commons
Amr H. Hashem, Samar H. Rizk, Mostafa A. Abdel-Maksoud

и другие.

RSC Advances, Год журнала: 2023, Номер 13(30), С. 20856 - 20867

Опубликована: Янв. 1, 2023

Bimetallic nanoparticles have received much attention recently due to their multifunctional applications, and synergistic potential at low concentrations. In the current study, bimetallic boron oxide-zinc oxide (B2O3-ZnO NPs) were synthesized by an eco-friendly, cost-effective method through utilization of gum arabic in presence gamma irradiation. Characterization B2O3-ZnO NPs revealed successful synthesis on nano-scale, good distribution, addition formation a stable colloidal nano-solution. Furthermore, assessed for anticancer, antimicrobial antioxidant activities. The evaluation cytotoxicity Vero Wi38 normal cell lines illustrated that are safe use where IC50 was 384.5 569.2 μg ml-1, respectively. had anticancer activity against Caco 2 80.1 ml-1. exhibited promising antibacterial E. coli, P. aeruginosa, B. subtilis S. aureus, MICs 125, 62.5, 125 62.5 ml-1 Likewise, antifungal C. albicans as unicellular fungi (MIC ml-1). Moreover, displayed (IC50 102.6 conclusion, novel successfully using under radiation, they

Язык: Английский

Employing algal extract for the fabrication of bimetallic nanoparticles: A powerful solution against tomato pathogenic fungi DOI Creative Commons
Reham M. Aldahasi, Kawther Aabed, Sahar S. Alghamdi

и другие.

AIP Advances, Год журнала: 2025, Номер 15(1)

Опубликована: Янв. 1, 2025

This study explores the innovative use of an aqueous spirulina and chlorella mixture to synthesize bimetallic zinc/manganese nanoparticles (ZnO–Mn NPs), showcasing a sustainable approach nanomaterial development. The were thoroughly characterized using advanced techniques, including UV–visible spectrophotometry, Fourier transform infrared spectroscopy (FTIR), dynamic light scattering, scanning electron microscopy, transmission energy-dispersive x-ray spectroscopy. These analyses revealed that ZnO–Mn NPs have average size 314.4 nm, polydispersity index 0.28, zeta potential −23.86 mV, indicating excellent stability uniform distribution. antifungal properties synthesized tested in vitro against key tomato pathogens, Sclerotinia sclerotiorum Fusarium equiseti. FTIR analysis highlighted role phytochemicals from algal extracts reduction capping nanoparticles. While activity observed was modest at evaluated concentrations, strong biocompatibility underscore their as eco-friendly solutions agricultural applications. research highlights promise utilizing natural develop effective nanoparticles, offering greener alternative for managing plant diseases enhancing farming practices.

Язык: Английский

Процитировано

2
Enhancement of Antibacterial, Anti-angiogenic and Anticancer Properties of Biosynthesized Zinc Oxide with Bioderived Mesoporous Carbon DOI
Alfredi A. Moyo,

Sneha R. Bhosale,

P.S. Patil

и другие.

Journal of Molecular Structure, Год журнала: 2025, Номер 1328, С. 141344 - 141344

Опубликована: Янв. 5, 2025

Язык: Английский

Процитировано

1
Enhanced Bioadhesive and Antimicrobial Properties of PVA/Ascorbic Acid Composite with Tannic Acid Synthesized by Gamma Irradiation for Biomedical Applications DOI Creative Commons

Shreen Adel Rashiq,

Nour E. A. Abd El‐Sattar,

Hanaa Abd ElKader Abd ElHamid

и другие.

ACS Omega, Год журнала: 2025, Номер unknown

Опубликована: Апрель 3, 2025

Bioadhesive hydrogels play a crucial role in biomedical applications due to their capacity adhere biological surfaces. This study investigates novel bioadhesive hydrogel system developed from poly(vinyl alcohol) (PVA) and ascorbic acid (AS), cross-linked through gamma irradiation at 7 kGy, modified with 5 wt % tannic (TA). The primary objective was enhance the hydrogel's bioadhesive, mechanical, antimicrobial properties. Mechanical testing revealed that (PVA/AS)/TA exhibited significant improvements, lap shear strength of 92 kPa, tensile 0.57 MPa, an elongation break 180%, compared unmodified variant. Antimicrobial efficacy assessed against bacterial strains, including Staphylococcus aureus Escherichia coli, showing potent inhibitory effects minimum concentration (MIC) values 25 μg/mL 30 μg/mL, respectively. findings indicate is promising candidate for wound healing, drug delivery, tissue engineering applications. It showcases its novelty improving properties while providing functionality, thus addressing critical challenges material design.

Язык: Английский

Процитировано

1
Sustainable approach for fabrication of pineapple agro-waste mediated cellulose nanocrystals embedded with Ag/Ag2O/ZnO nanocomposites for efficient removal of waterborne pathogens in wastewater DOI
Samudrika Aththanayaka, Gobika Thiripuranathar, Sagarika Ekanayake

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 310, С. 143272 - 143272

Опубликована: Апрель 18, 2025

Язык: Английский

Процитировано

1
Biogenic nanoparticles from waste fruit peels: Synthesis, applications, challenges and future perspectives DOI

Priya,

Sumel Ashique, Obaid Afzal

и другие.

International Journal of Pharmaceutics, Год журнала: 2023, Номер 643, С. 123223 - 123223

Опубликована: Июль 11, 2023

Язык: Английский

Процитировано

23
Amomum subulatum Fruit Extract Mediated Green Synthesis of Silver and Copper Oxide Nanoparticles: Synthesis, Characterization, Antibacterial and Anticancer Activities DOI Open Access

Sarika Dhir,

Rohit Dutt, Rahul Pratap Singh

и другие.

Processes, Год журнала: 2023, Номер 11(9), С. 2698 - 2698

Опубликована: Сен. 9, 2023

This research presents a straightforward, effective, and eco-friendly method for the production of silver nanoparticles (AgNPs) copper oxide (CuONPs) using dried fruit Amomum subulatum as reducing, stabilizing, capping agent. The formation AgNPs CuONPs is supported by presence surface plasmon resonance band (SPR) at 440 nm 245 CuONPs. Additionally, identification specific biomolecules responsible synthesis was confirmed through FTIR spectra analysis. Transmission electron microscope (TEM) images demonstrated that had spherical shapes, with mean particle diameters 20.6 24.7 nm, respectively. X-ray diffraction selected area (SAED) analyses provided evidence crystalline nature synthesized elements observed energy-dispersive spectroscopy (EDS) Furthermore, antibacterial activity found to be superior against human pathogens such Escherichia coli, Staphylococcus aureus, Bacillus subtilis. cytotoxic biosynthesized (NPs) evaluated in vitro cervical cells (HeLa) breast (MCF-7). In MCF-7 cells, IC50 value estimated 39.79 µg/mL, while 83.89 µg/mL. HeLa 45.5 CuONPs, it 97.07 For first time, an from extract has been discussed along their comparative evaluation study. These results highlight promising applications effective agents microbial infections potential candidates cancer therapy.

Язык: Английский

Процитировано

18
Phyto-mediated synthesis of Ag, ZnO, and Ag/ZnO nanoparticles from leave extract of Solanum macrocarpon: Evaluation of their antioxidant and anticancer activities DOI Creative Commons
Marwa Yousry A. Mohamed, Hela Ferjani, Oluwasayo E. Ogunjinmi

и другие.

Inorganica Chimica Acta, Год журнала: 2024, Номер 569, С. 122086 - 122086

Опубликована: Апрель 24, 2024

Язык: Английский

Процитировано

9
In Vivo and in Vitro activity of colistin-conjugated bimetallic silver-copper oxide nanoparticles against Pandrug-resistant Pseudomonas aeruginosa DOI Creative Commons

Asmaa Abdul Hak,

Hamdallah Zedan, Hadir A. El‐Mahallawy

и другие.

BMC Microbiology, Год журнала: 2024, Номер 24(1)

Опубликована: Июнь 17, 2024

Abstract Background Addressing microbial resistance urgently calls for alternative treatment options. This study investigates the impact of a bimetallic formulation containing colistin, silver, and copper oxide on pandrug-resistant, highly virulent Pseudomonas aeruginosa (P. aeruginosa) isolate from cancer patient at National Cancer Institute, Cairo University, Egypt. Methods Silver nanoparticles (Ag NPs), (CuO silver-copper (Ag-CuO NPs) were synthesized using gamma rays, combined with colistin (Col), characterized by various analytical methods. The antimicrobial activity Col-Ag NPs, Col-CuO Col-Ag-CuO NPs against P. was evaluated agar well diffusion method, their minimum inhibitory concentration (MIC) determined broth microdilution. Virulence factors such as pyocyanin production, swarming motility, biofilm formation assessed before after NPs. in vivo efficacy Galleria mellonella model, antibacterial mechanism examined through membrane leakage assay. Results optimal synthesis Ag occurred ray dose 15.0 kGy, highest optical density (OD) 2.4 375 nm. Similarly, CuO had an OD 1.5 330 Bimetallic Ag-CuO most potent yielding 1.9 425 MIC significantly reduced when nanoparticles: 8 µg/mL alone, 0.046 0.0117 four-fold compared to Increasing sub-inhibitory 0.29 × 10 -2 0.58 32–64% twitching motility 34–97%. At these concentrations, production decreased 39–58%, inhibited 33–48%. non-toxic , showing 100% survival day 3, similar saline-treated group. Conclusions conjugated presents promising combating challenging pathogen hospital settings. Further research is needed explore elucidate mechanisms underlying effects colistin-bimetallic persistence dissemination.

Язык: Английский

Процитировано

9
Green biosynthesis of bimetallic selenium–gold nanoparticles using Pluchea indica leaves and their biological applications DOI Creative Commons
Ahmed Mohamed Aly Khalil, Ebrahim Saied, Alsayed E. Mekky

и другие.

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 11

Опубликована: Янв. 11, 2024

Increasing bacterial resistance and the negative impact of currently used antibacterial agents have produced need for novel anticancer drugs. In this regard, nanotechnology could provide safer more efficient therapeutic agents. The main methods nanoparticle production are chemical physical approaches that often costly environmentally unsafe. current study, Pluchea indica leaf extract was biosynthesis bimetallic selenium–gold nanoparticles (Se-Au BNPs) first time. Phytochemical examinations revealed P. includes 90.25 mg/g dry weight (DW) phenolics, 275.53 DW flavonoids, 26.45 tannins. X-ray diffraction (XRD), transmission electron microscopy (TEM), Fourier-transform infrared (FTIR) spectroscopy, dynamic light scattering (DLS), scanning (SEM), energy-dispersive spectroscopy (EDX) techniques were employed to characterize Se-Au BNPs. Based on UV-vis spectra, absorbance BNPs peaked at 238 374 nm. SEM imaging, emerged as bright particles, both Au Se uniformly distributed throughout extract. XRD analysis average size 45.97 showed properties against Escherichia coli , Pseudomonas aeruginosa Staphylococcus aureus Bacillus subtilis with minimum inhibitory concentrations (MICs) 31.25, 15.62, 3.9 μg/mL, respectively. Surprisingly, a cytotoxicity assay IC 50 value toward Wi 38 normal cell line 116.8 implying all MICs described above be safely. More importantly, shown higher efficacy human breast cancer cells (MCF7), an 13.77 μg/mL. conclusion, paper is data effective utilization in biologically active

Язык: Английский

Процитировано

7
Amine-functionalized mesoporous silica nanoparticles decorated by silver nanoparticles for delivery of doxorubicin in breast and cervical cancer cells DOI Creative Commons

Melika Ghobadi,

Saeideh Salehi,

Mohammad Taha Salmanifard Ardestani

и другие.

European Journal of Pharmaceutics and Biopharmaceutics, Год журнала: 2024, Номер 201, С. 114349 - 114349

Опубликована: Июнь 5, 2024

Nanocarriers have demonstrated promising potential in the delivery of various anticancer drugs and improving efficiency treatment. In this study, silver nanoparticles (AgNPs) were green-synthesized using extracts different parts pomegranate plant, including peel, flower petals, calyx. To obtain most efficient extract used for green synthesis AgNPs, all three types synthesized characterized. Then, (3-Aminopropyl) triethoxysilane-functionalized mesoporous silica (MSNs-APTES) decorated with AgNPs fabricated via a one-pot green-synthesis method. directly coated on surface MSNs-APTES by adding enriched source reducing agent leading to converting ion AgNPs. The MSN-APTES-AgNPs (MSNs-AgNPs) been thoroughly characterized nanoparticle characterization techniques. addition, DNA cleavage hemolysis activities analyzed, confirming biocompatibility nanoparticles. Doxorubicin (DOX, as breast/cervical anti-cancer drug) loading (42.8%) release profiles investigated UV–visible spectroscopy. fibroblast, breast cancer, cervical cancer cells' viability against DOX-loaded also studied. results high drug loading, uniform shape, small functionalized its great management.

Язык: Английский

Процитировано

7