Background:
Tribulus
terrestris,
a
plant
known
for
its
pharmacological
properties,
was
investigated
in
this
study
potential
anticancer
effects
against
oral
cancer
cells.
The
aimed
to
explore
the
phytochemical
composition
of
T.
terrestris
seed
extract
and
evaluate
cytotoxic,
pro-apoptotic,
antioxidant,
anti-inflammatory,
antimicrobial
activities.
Materials
methods:
Methanolic
extracts
were
obtained
subjected
analysis
identify
bioactive
compounds.
cytotoxic
effect
on
cells
evaluated
using
MTT
(3-(4,
5-dimethylthiazolyl-2)-2,
5-diphenyltetrazolium
bromide)
assay,
while
pro-apoptotic
assessed
through
dual
fluorescent
staining.
Antioxidant
activity
measured
hydrogen
peroxide
erythrocyte
aggregation
assays,
anti-inflammatory
inhibition
albumin
denaturation.
Results:
Phytochemical
revealed
presence
alkaloids,
tannins,
saponins,
flavonoids,
phenols
extract.
demonstrated
concentration-dependent
cytotoxicity
cells,
with
100
μg/mL
showing
significant
growth
inhibition.
Pro-apoptotic
observed,
characteristic
morphological
changes
treated
by
extract,
methanol
fraction
flower
(MFF)
exhibiting
highest
capacity,
followed
total
trichome
(TTF),
positive
correlation
between
phenolic
content
free
radical
scavenging
effectiveness
noted.
Antimicrobial
various
pathogens,
including
bacteria
fungi,
also
higher
concentrations
increased
efficacy.
Conclusion:
concludes
that
methanolic
possess
anticancer,
These
findings
highlight
as
candidate
further
research
clinical
applications,
either
alone
or
combination
other
agents,
treatment
associated
conditions.
Pharmaceuticals,
Год журнала:
2025,
Номер
18(6), С. 799 - 799
Опубликована: Май 26, 2025
Background/Objectives:
The
rise
of
bacterial
resistance
and
the
search
for
alternative,
biocompatible
antimicrobial
materials
have
driven
interest
in
natural-based
nanocomposites.
In
this
context,
silver
nanoparticles
(AgNPs)
shown
broad-spectrum
antibacterial
activity,
cellulose
(BC)
is
widely
recognized
its
high
purity,
hydrophilicity,
biocompatibility.
This
study
aimed
to
develop
a
bio-based
BC–AgNP
nanocomposite
via
green
synthesis
using
Astrocaryum
aculeatum
(tucumã)
extract
assess
performance
wound
dressing
applications.
Methods:
BC
was
biosynthesized
tea
fermentation
(20
g/L
100
sugar)
purified
prior
use.
AgNPs
were
obtained
by
reacting
aqueous
tucumã
with
nitrate
(0.1
mmol/L)
at
pH
(9)
temperature
(40
°C).
membranes
immersed
dispersion
7
days
form
nanocomposite.
Characterization
performed
UV–Vis,
DLS,
TEM,
SEM–EDS,
FTIR,
XRD,
ICP–OES,
swelling
analysis.
Antibacterial
activity
evaluated
disk
diffusion
method
against
Staphylococcus
aureus
Escherichia
coli
(ATCC
6538
4388).
Results:
UV–Vis
spectra
revealed
gradual
decrease
surface
plasmon
resonance
(SPR)
band
over
incubation
BC,
indicating
progressive
incorporation
into
membrane.
ICP
analysis
confirmed
membrane
0.00215
mg/mL,
corresponding
15.5%
initial
content.
Antimicrobial
assays
showed
inhibition
zones
6.5
±
0.5
mm
S.
4.3
0.3
E.
coli.
Conclusions:
These
findings
validate
successful
formation
nanocomposite,
supporting
potential
use
care
Introduction:
The
primary
objective
of
this
study
was
to
develop
an
environmentally
friendly
and
efficient
method
for
synthesizing
zinc
oxide
(ZnO)
nanoparticles
(NPs),
utilizing
extracts
from
Allium
sativum
(garlic)
plants,
characterizing
the
synthesized
ZnO
NPs
using
various
analytical
techniques,
assessing
their
antibacterial
antioxidant
properties.
Materials
Methods:
synthesis
process
involved
garlic
plants
create
NPs.
were
subjected
comprehensive
characterization
through
UV-visible
(UV-vis)
spectroscopy,
Fourier-transform
infrared
spectroscopy
(FTIR),
scanning
electron
microscopy
(SEM),
X-ray
diffraction
(XRD).
Antibacterial
properties
assessed
against
different
microbial
strains.
In
vitro
evaluated
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic
acid
(ABTS)
assays.
Bioactive
compounds
in
also
identified.
Results:
Analysis
UV-vis
spectrum
confirmed
with
approximate
size
280
nm,
as
indicated
by
absorption
peak
surface
plasmon
resonance
band.
FTIR
revealed
presence
functional
groups
such
hydroxyl
carboxyl
groups.
SEM
analysis
determined
dimensions
be
around
11
nm.
XRD
patterns
exhibited
distinct
Bragg
reflections,
confirming
specific
crystallographic
planes.
assays
demonstrated
a
reduction
absorbance
at
517
nm
734
indicating
activity.
testing
inhibition
zones
Escherichia
coli,
Staphylococcus
aureus,
Streptococcus
mutans,
Enterococcus
faecalis.
Conclusion:
successfully
eco-friendly
plant
extracts.
Characterization
techniques
structural
chemical
activities,
showcasing
potential
applications.
identification
bioactive
further
contributes
understanding
biological
