Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 12, 2024
Background:
Tribulus
terrestris,
a
plant
known
for
its
pharmacological
properties,
was
investigated
in
this
study
potential
anticancer
effects
against
oral
cancer
cells.
The
aimed
to
explore
the
phytochemical
composition
of
T.
terrestris
seed
extract
and
evaluate
cytotoxic,
pro-apoptotic,
antioxidant,
anti-inflammatory,
antimicrobial
activities.
Materials
methods:
Methanolic
extracts
were
obtained
subjected
analysis
identify
bioactive
compounds.
cytotoxic
effect
on
cells
evaluated
using
MTT
(3-(4,
5-dimethylthiazolyl-2)-2,
5-diphenyltetrazolium
bromide)
assay,
while
pro-apoptotic
assessed
through
dual
fluorescent
staining.
Antioxidant
activity
measured
hydrogen
peroxide
erythrocyte
aggregation
assays,
anti-inflammatory
inhibition
albumin
denaturation.
Results:
Phytochemical
revealed
presence
alkaloids,
tannins,
saponins,
flavonoids,
phenols
extract.
demonstrated
concentration-dependent
cytotoxicity
cells,
with
100
μg/mL
showing
significant
growth
inhibition.
Pro-apoptotic
observed,
characteristic
morphological
changes
treated
by
extract,
methanol
fraction
flower
(MFF)
exhibiting
highest
capacity,
followed
total
trichome
(TTF),
positive
correlation
between
phenolic
content
free
radical
scavenging
effectiveness
noted.
Antimicrobial
various
pathogens,
including
bacteria
fungi,
also
higher
concentrations
increased
efficacy.
Conclusion:
concludes
that
methanolic
possess
anticancer,
These
findings
highlight
as
candidate
further
research
clinical
applications,
either
alone
or
combination
other
agents,
treatment
associated
conditions.
Cureus,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 28, 2024
Introduction:
The
primary
objective
of
this
study
was
to
develop
an
environmentally
friendly
and
efficient
method
for
synthesizing
zinc
oxide
(ZnO)
nanoparticles
(NPs),
utilizing
extracts
from
Allium
sativum
(garlic)
plants,
characterizing
the
synthesized
ZnO
NPs
using
various
analytical
techniques,
assessing
their
antibacterial
antioxidant
properties.
Materials
Methods:
synthesis
process
involved
garlic
plants
create
NPs.
were
subjected
comprehensive
characterization
through
UV-visible
(UV-vis)
spectroscopy,
Fourier-transform
infrared
spectroscopy
(FTIR),
scanning
electron
microscopy
(SEM),
X-ray
diffraction
(XRD).
Antibacterial
properties
assessed
against
different
microbial
strains.
In
vitro
evaluated
2,2-diphenyl-1-picrylhydrazyl
(DPPH)
2,2-azino-bis-3-ethylbenzothiazoline-6-sulphonic
acid
(ABTS)
assays.
Bioactive
compounds
in
also
identified.
Results:
Analysis
UV-vis
spectrum
confirmed
with
approximate
size
280
nm,
as
indicated
by
absorption
peak
surface
plasmon
resonance
band.
FTIR
revealed
presence
functional
groups
such
hydroxyl
carboxyl
groups.
SEM
analysis
determined
dimensions
be
around
11
nm.
XRD
patterns
exhibited
distinct
Bragg
reflections,
confirming
specific
crystallographic
planes.
assays
demonstrated
a
reduction
absorbance
at
517
nm
734
indicating
activity.
testing
inhibition
zones
Escherichia
coli,
Staphylococcus
aureus,
Streptococcus
mutans,
Enterococcus
faecalis.
Conclusion:
successfully
eco-friendly
plant
extracts.
Characterization
techniques
structural
chemical
activities,
showcasing
potential
applications.
identification
bioactive
further
contributes
understanding
biological
Nanomedicine,
Journal Year:
2024,
Volume and Issue:
19(14), P. 1253 - 1269
Published: May 8, 2024
Cancer
is
one
of
the
leading
causes
mortality
worldwide,
and
its
treatment
faces
several
challenges.
Phytoconstituents
derived
from
recently
discovered
medicinal
plants
through
nanotechnology
potentially
target
cancer
cells
via
PI3K/Akt/mTOR
pathways
exert
their
effects
selectively
generation
reactive
oxygen
species
β-catenin
inhibition,
DNA
damage,
increasing
caspase
3/9
p53
expression.
These
nanocarriers
act
specifically
against
different
cell
lines
such
as
HT-29,
MOLT-4
human
leukemia
MCF-7
SKOV-3,
Caov-3,
SW-626,
HepG2,
A-549,
HeLa,
MCF-7.
This
review
comprehensively
elaborates
on
cellular
molecular
mechanisms,
therapeutic
prospects
various
plant-mediated
nanoformulations
to
attain
a
revolutionary
shift
in
immunotherapy.
