Cellular Oncology, Год журнала: 2020, Номер 43(5), С. 863 - 876
Опубликована: Июль 29, 2020
Язык: Английский
Seminars in Cancer Biology, Год журнала: 2020, Номер 75, С. 38 - 48
Опубликована: Дек. 18, 2020
Язык: Английский
Процитировано
243
Pathology - Research and Practice, Год журнала: 2023, Номер 253, С. 154991 - 154991
Опубликована: Ноя. 30, 2023
Язык: Английский
Процитировано
74
iScience, Год журнала: 2024, Номер 27(6), С. 109979 - 109979
Опубликована: Май 15, 2024
This review explores the hallmarks of cancer resistance, including drug efflux mediated by ATP-binding cassette (ABC) transporters, metabolic reprogramming characterized Warburg effect, and dynamic interplay between cells mitochondria. The role stem (CSCs) in treatment resistance regulatory influence non-coding RNAs, such as long RNAs (lncRNAs), microRNAs (miRNAs), circular (circRNAs), are studied. chapter emphasizes future directions, encompassing advancements immunotherapy, strategies to counter adaptive integration artificial intelligence for predictive modeling, identification biomarkers personalized treatment. comprehensive exploration these provides a foundation innovative therapeutic approaches, aiming navigate complex landscape enhance patient outcomes.
Язык: Английский
Процитировано
26
Seminars in Cancer Biology, Год журнала: 2020, Номер 83, С. 303 - 318
Опубликована: Ноя. 15, 2020
Язык: Английский
Процитировано
96
Genes, Год журнала: 2019, Номер 10(1), С. 52 - 52
Опубликована: Янв. 16, 2019
In contrast to the amazing exponential growth in knowledge related long non-coding RNAs (lncRNAs) involved cell homeostasis or dysregulated pathological states, little is known so far about links between chemical modifications occurring lncRNAs and their function. Generally, ncRNAs are post-transcriptional regulators of gene expression, but RNA generate an additional layer expression control. Chemical that have been reported correlation with include m6A, m5C pseudouridylation. Up date, several chemically modified transcripts identified associated different pathologies, including cancers. This review presents current level on most studied cancer-related lncRNAs, such as metastasis lung adenocarcinoma transcript 1 (MALAT1), Hox antisense intergenic (HOTAIR), X-inactive specific (XIST), well more recently discovered forms, potential roles types cancer. Understanding how these occur, lncRNA changes structure function, may open up new therapeutic possibilities
Язык: Английский
Процитировано
91
Cellular Oncology, Год журнала: 2019, Номер 42(6), С. 757 - 768
Опубликована: Июль 29, 2019
Язык: Английский
Процитировано
89
Frontiers in Genetics, Год журнала: 2022, Номер 13
Опубликована: Июль 22, 2022
Background: Cuproptosis is a new type of cell death that induces protein toxic stress and eventually leads to death. Hence, regulating cuproptosis in tumor cells therapeutic approach. However, studies on cuproptosis-related long noncoding RNA (lncRNA) head neck squamous carcinoma (HNSC) have not been found. This study aimed explore the lncRNAs prognostic marker their relationship immune microenvironment HNSC by using bioinformatics methods. Methods: sequencing, genomic mutations, clinical data TCGA_HNSC were downloaded from The Cancer Genome Atlas. patients randomly assigned either training group or validation cohort. least absolute shrinkage selection operator Cox regression multivariate models used determine model cohort, its independent effect was further confirmed entire cohorts. Results: Based previous literature, we collected 19 genes associated with cuproptosis. Afterward, 783 obtained through coexpression. revealed constructed eight (AL132800.1, AC090587.1, AC079160.1, AC011462.4, AL157888.1, GRHL3-AS1, SNHG16, AC021148.2). Patients divided into high- low-risk groups based median risk score. Kaplan-Meier survival curve overall between statistically significant. receiver operating characteristic principal component analysis demonstrated accurate ability model. Univariate showed score an factor. In addition, establish nomogram predictive power markers. mutation burden significant differences groups. high-risk responded better immunotherapy than those group. We also found scores significantly drug sensitivity HNSC. Conclusion: summary, our identified cuprotosis-related signature as predictor, which may be promising biomarkers for predicting benefit well sensitivity.
Язык: Английский
Процитировано
69
Nanoscale, Год журнала: 2024, Номер 16(8), С. 3881 - 3914
Опубликована: Янв. 1, 2024
The long noncoding RNAs (lncRNAs) comprise a wide range of RNA species whose length exceeds 200 nucleotides, which regulate the expression genes and cellular functions in organisms.
Язык: Английский
Процитировано
13
Cancers, Год журнала: 2024, Номер 16(1), С. 234 - 234
Опубликована: Янв. 4, 2024
Metastasis-associated lung adenocarcinoma transcript-1 (MALAT-1) is a long intergenic non-coding RNA (lncRNA) located on chr11q13. It overexpressed in several cancers and controls gene expression through chromatin modification, transcriptional regulation, post-transcriptional regulation. Importantly, MALAT-1 stimulates cell proliferation, migration, metastasis serves vital role driving the epithelial-to-mesenchymal transition (EMT), subsequently acquiring cancer stem cell-like properties developing drug resistance. modulates EMT by interacting with various intracellular signaling pathways, notably phosphoinositide 3-kinase (PI3K)/Akt Wnt/β-catenin pathways. also behaves like sponge for microRNAs, preventing their interaction target genes promoting EMT. In addition, we have used bioinformatics online tools to highlight disparities of between normal samples using data from The Cancer Genome Atlas (TCGA). Furthermore, intricate interplay essential targets progression renders it good candidate therapeutic interventions. Several innovative approaches been exploited MALAT-1, such as short hairpin RNAs (shRNAs), antisense oligonucleotides (ASOs), natural products. This review emphasizes modulating metastasis, stemness, chemoresistance different cancers.
Язык: Английский
Процитировано
12
Bioorganic & Medicinal Chemistry, Год журнала: 2019, Номер 27(11), С. 2253 - 2260
Опубликована: Апрель 6, 2019
Язык: Английский
Процитировано
77