ACS Omega,
Год журнала:
2025,
Номер
10(13), С. 13645 - 13654
Опубликована: Март 27, 2025
This
is
the
report
of
HPLC-MSn-guided
isolation
new
anti-inflammatory
prenylated
isoflavonoids
and
pterocarpans
from
stems
Acosmium
diffusissimum
using
GNPS
molecular
networking
as
main
tool.
Cluster
analysis
guided
five
isoflavonoids,
diffusiflavone
A-E
(1-4
9),
two
pterocarpans,
diffusicarpan
A
B
(5
6),
known
compounds
6-prenylorobol
(7)
3-O-methylquercetin
(8).
The
in
vitro
potential
1-6
9
was
assessed
macrophages
induced
with
lipopolysaccharide
(LPS).
Compounds
2,
3,
5,
were
observed
to
have
a
reduction
NO
levels
at
least
one
concentrations
tested
(1.25,
2.5,
10,
20
μg/mL)
also
reduced
IL-1β
IL-6
cytokines,
especially
which
cytokine
all
tested.
Heliyon,
Год журнала:
2023,
Номер
9(12), С. e23171 - e23171
Опубликована: Дек. 1, 2023
Tumor-mediated
bypass
of
immune
checkpoint
inhibitor
(ICI)
therapy
with
anti-programmed
death-1
(PD-1),
death-ligand
1
(PD-L1,
also
called
B7-H1
or
CD274)
anti-cytotoxic
T
lymphocyte
associated
antigen-4
(CTLA-4)
is
a
challenge
current
years
in
the
area
cancer
immunotherapy.
Alternative
checkpoints
(AICs)
are
molecules
beyond
common
PD-1,
PD-L1
CTLA-4,
and
upregulated
patients
who
show
low/no
ICI
responses.
These
members
B7
family
including
B7-H2
(ICOS-L),
B7-H3
(CD276),
B7-H4
(B7x),
V-domain
immunoglobulin
suppressor
cell
activation
(VISTA),
B7-H6,
HHLA2
(B7-H5/B7-H7)
catabolic
enzymes
like
indoleamine
2,3-dioxygenase
(IDO1),
others
that
contributed
to
regulation
tumor
microenvironment
(TIME).
There
strong
evidence
supporting
implication
AICs
stemness
expanding
population
stem
cells
(CSCs).
CSCs
display
immunoregulatory
capacity
represent
multiple
either
on
their
surface
inside.
Besides,
they
active
promoters
resistance
ICIs.
The
aim
this
review
investigate
interrelations
between
differentiation
profile
cancer.
key
message
paper
targeted
can
be
selected
based
impact
along
effect
cells.
Studies
published
so
far
mainly
focused
as
target
for
anti-checkpoints.
Ex
vivo
engineering
extracellular
vesicles
(EVs)
equipped
CSC-targeted
anti-checkpoint
antibodies
without
doubt
therapeutic
under
consideration
future
research.
Frontiers in Immunology,
Год журнала:
2022,
Номер
13
Опубликована: Ноя. 23, 2022
The
general
immune
state
plays
important
roles
against
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
infection.
Cells
of
the
system
are
encountering
rapid
changes
during
phase
SARS-CoV-2-induced
disease.
Reduced
fraction
functional
CD8
+
T
cells,
disrupted
cross-talking
between
cells
with
dendritic
(DCs),
and
impaired
immunological
T-cell
memory,
along
higher
presence
hyperactive
neutrophils,
high
expansion
myeloid-derived
suppressor
(MDSCs)
non-classical
monocytes,
attenuated
cytotoxic
capacity
natural
killer
(NK)
all
indicative
low
efficient
immunity
viral
surge
within
body.
Immune
responses
from
pro-
or
anti-inflammatory
to
SARS-CoV-2
discussed
in
this
review.
We
also
suggest
some
strategies
enhance
power
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Июнь 21, 2024
Abstract
Background
Cancer
recurrence
following
surgical
resection
is
a
major
cause
of
treatment
failure.
Finding
effective
methods
to
prevent
postoperative
and
wound
infection
an
important
component
successful
surgery.
With
the
development
new
nanotechnology,
more
options
have
been
provided
for
adjuvant
therapy.
This
study
presents
innovative
hydrogel
system
that
stimulates
tumoricidal
immunity
after
non-small
cell
lung
cancer
(NSCLC)
prevents
relapse.
Results
The
based
on
excellent
photothermal
conversion
performance
single-atom
platinum
(CN-Pt)
along
with
delivery
release
chemotherapy
drug,
gemcitabine
(GEM).
coated
onto
surface
tumor
removal
subsequent
near-infrared
(NIR)
therapy,
which
efficiently
induces
necroptosis
residual
cells,
amplifies
levels
damage-associated
molecular
patterns
(DAMPs),
increases
number
M1
macrophages.
significantly
higher
phagocytic
macrophages
enhance
immunogenicity
sensitize
cells
CD8
+
T-cell
control
recurrence,
has
verified
using
animal
model
recurrence.
CN-Pt-GEM-hydrogel
NIR
can
also
inhibit
infection.
Conclusions
These
findings
introduce
alternative
strategy
supplementing
antitumor
in
patients
undergoing
NSCLC
tumors.
exhibits
good
biosafety
may
be
adaptable
clinical
application
relation
surgery,
tissue
filling,
prevention,
prevention.
ACS Omega,
Год журнала:
2025,
Номер
10(13), С. 13645 - 13654
Опубликована: Март 27, 2025
This
is
the
report
of
HPLC-MSn-guided
isolation
new
anti-inflammatory
prenylated
isoflavonoids
and
pterocarpans
from
stems
Acosmium
diffusissimum
using
GNPS
molecular
networking
as
main
tool.
Cluster
analysis
guided
five
isoflavonoids,
diffusiflavone
A-E
(1-4
9),
two
pterocarpans,
diffusicarpan
A
B
(5
6),
known
compounds
6-prenylorobol
(7)
3-O-methylquercetin
(8).
The
in
vitro
potential
1-6
9
was
assessed
macrophages
induced
with
lipopolysaccharide
(LPS).
Compounds
2,
3,
5,
were
observed
to
have
a
reduction
NO
levels
at
least
one
concentrations
tested
(1.25,
2.5,
10,
20
μg/mL)
also
reduced
IL-1β
IL-6
cytokines,
especially
which
cytokine
all
tested.
