NIR-responsive CN-Pt-GEM hydrogel induces necroptosis and immunotherapeutic responses prevent postoperative recurrence and wound infection in lung carcinoma DOI Creative Commons
Meng Wang, Rui Cai, Zhiwu Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 21, 2024

Abstract Background Cancer recurrence following surgical resection is a major cause of treatment failure. Finding effective methods to prevent postoperative and wound infection an important component successful surgery. With the development new nanotechnology, more options have been provided for adjuvant therapy. This study presents innovative hydrogel system that stimulates tumoricidal immunity after non-small cell lung cancer (NSCLC) prevents relapse. Results The based on excellent photothermal conversion performance single-atom platinum (CN-Pt) along with delivery release chemotherapy drug, gemcitabine (GEM). coated onto surface tumor removal subsequent near-infrared (NIR) therapy, which efficiently induces necroptosis residual cells, amplifies levels damage-associated molecular patterns (DAMPs), increases number M1 macrophages. significantly higher phagocytic macrophages enhance immunogenicity sensitize cells CD8 + T-cell control recurrence, has verified using animal model recurrence. CN-Pt-GEM-hydrogel NIR can also inhibit infection. Conclusions These findings introduce alternative strategy supplementing antitumor in patients undergoing NSCLC tumors. exhibits good biosafety may be adaptable clinical application relation surgery, tissue filling, prevention, prevention.

Language: Английский

T-cell immunoglobulin and ITIM domain as a target in combo anti-PD-(L)1 cancer therapy DOI
Keywan Mortezaee

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143557 - 143557

Published: April 26, 2025

Language: Английский

Citations

0
Roles of Interleukin-6-mediated immunometabolic reprogramming in COVID-19 and other viral infection-associated diseases DOI
Yingshuang Li,

Hua-Cheng Ren,

Jian-hua Cao

et al.

International Immunopharmacology, Journal Year: 2022, Volume and Issue: 110, P. 109005 - 109005

Published: June 28, 2022

Language: Английский

Citations

17
Dysregulated metabolism: A friend-to-foe skewer of macrophages DOI
Keywan Mortezaee, Jamal Majidpoor

International Reviews of Immunology, Journal Year: 2022, Volume and Issue: 42(4), P. 287 - 303

Published: July 6, 2022

Metabolic reprogramming is a hallmark of solid cancers. Macrophages as major constituents immune system take important roles in regulation tumorigenesis. Pro-tumor M2 macrophages preferentially use oxidative phosphorylation (OXPHOS) to meet their metabolic demands, while anti-tumor M1 glycolysis dominant source. Dysregulation systems driving force skewing from toward phenotypical state. Hyperactive macrophages, for instance, release products that are contributed macrophage polarization. Thus, remodeling through reinstating normalization can be an effective tool cancer therapy. The key focus this review over and factors influencing acquisition cancer, well discussing bout strategies adjust metabolism reeducation M1-like phenotype.

Language: Английский

Citations

16
Cellular immune states in SARS-CoV-2-induced disease DOI Creative Commons
Keywan Mortezaee, Jamal Majidpoor

Frontiers in Immunology, Journal Year: 2022, Volume and Issue: 13

Published: Nov. 23, 2022

The general immune state plays important roles against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Cells of the system are encountering rapid changes during phase SARS-CoV-2-induced disease. Reduced fraction functional CD8 + T cells, disrupted cross-talking between cells with dendritic (DCs), and impaired immunological T-cell memory, along higher presence hyperactive neutrophils, high expansion myeloid-derived suppressor (MDSCs) non-classical monocytes, attenuated cytotoxic capacity natural killer (NK) all indicative low efficient immunity viral surge within body. Immune responses from pro- or anti-inflammatory to SARS-CoV-2 discussed in this review. We also suggest some strategies enhance power

Language: Английский

Citations

14
NIR-responsive CN-Pt-GEM hydrogel induces necroptosis and immunotherapeutic responses prevent postoperative recurrence and wound infection in lung carcinoma DOI Creative Commons
Meng Wang, Rui Cai, Zhiwu Zhang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 21, 2024

Abstract Background Cancer recurrence following surgical resection is a major cause of treatment failure. Finding effective methods to prevent postoperative and wound infection an important component successful surgery. With the development new nanotechnology, more options have been provided for adjuvant therapy. This study presents innovative hydrogel system that stimulates tumoricidal immunity after non-small cell lung cancer (NSCLC) prevents relapse. Results The based on excellent photothermal conversion performance single-atom platinum (CN-Pt) along with delivery release chemotherapy drug, gemcitabine (GEM). coated onto surface tumor removal subsequent near-infrared (NIR) therapy, which efficiently induces necroptosis residual cells, amplifies levels damage-associated molecular patterns (DAMPs), increases number M1 macrophages. significantly higher phagocytic macrophages enhance immunogenicity sensitize cells CD8 + T-cell control recurrence, has verified using animal model recurrence. CN-Pt-GEM-hydrogel NIR can also inhibit infection. Conclusions These findings introduce alternative strategy supplementing antitumor in patients undergoing NSCLC tumors. exhibits good biosafety may be adaptable clinical application relation surgery, tissue filling, prevention, prevention.

Language: Английский

Citations

2