Computational Modelling and Simulation of Scaffolds for Bone Tissue Engineering

Computation, Год журнала: 2024, Номер 12(4), С. 74 - 74

Опубликована: Апрель 4, 2024

Three-dimensional porous scaffolds are substitutes for traditional bone grafts in tissue engineering (BTE) applications to restore and treat injuries defects. The use of computational modelling is gaining momentum predict the parameters involved healing cell seeding procedures perfusion bioreactors reach final goal optimal growth. Computational based on finite element method (FEM) fluid dynamics (CFD) two standard methodologies utilised investigate equivalent mechanical properties scaffolds, as well flow characteristics inside respectively. success a simulation hinges selection relevant mathematical model with proper initial boundary conditions. This review paper aims provide insights researchers regarding appropriate (FE) models different materials CFD regimes bioreactors. Thus, these FEM/CFD may help create efficient designs by predicting their structural haemodynamic responses prior vitro vivo (TE) applications.

Язык: Английский

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Advances in 3D printing technology for preparing bone tissue engineering scaffolds from biodegradable materials

Frontiers in Bioengineering and Biotechnology, Год журнала: 2024, Номер 12

Опубликована: Ноя. 14, 2024

Introduction Bone tissue engineering (BTE) provides an effective repair solution by implanting osteoblasts or stem cells into biocompatible and biodegradable scaffolds to promote bone regeneration. In recent years, the rapid development of 3D bioprinting has enabled its extensive application in fabricating BTE scaffolds. Based on three-dimensional computer models specialized “bio-inks,” this technology offers new pathways for customizing This study reviews current status future prospects scaffold materials bioprinting. Methods literature review collected studies bioprinting, analyzing advantages limitations various printing, including bioceramics, metals, natural polymers, synthetic polymers. Key characteristics like biocompatibility, mechanical properties, degradation rates these were systematically compared. Results The highlights diverse performances used Bioceramics exhibit excellent biocompatibility but suffer from brittleness; metals offer high strength may induce chronic inflammation; polymers are yet have poor while strong tunability produce acidic by-products during degradation. Additionally, integrating with composite could enhance presenting viable solutions challenges. Discussion summarizes advances applications, exploring strengths proposing material combinations improve performance. By optimizing selection combinations, shows promise creating customized scaffolds, offering a technical route clinical applications BTE. research unique perspective theoretical support advancing regeneration, outlining directions development.

Язык: Английский

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E-jet printed polycaprolactone with strontium-substituted mesoporous bioactive glass nanoparticles for bone tissue engineering

Biomaterials Advances, Год журнала: 2025, Номер 169, С. 214173 - 214173

Опубликована: Янв. 2, 2025

Язык: Английский

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Stimuli-responsive smart materials: Bridging the gap between biotechnology and regenerative medicine

Bioprinting, Год журнала: 2025, Номер 48, С. e00415 - e00415

Опубликована: Апрель 15, 2025

Язык: Английский

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Controlled Release of Ionic Carrier Hydrogels for Sequential Immunomodulation to Facilitate Stage-specific Treatment of Infectious Wound

Biomaterials, Год журнала: 2025, Номер 322, С. 123376 - 123376

Опубликована: Май 8, 2025

Язык: Английский

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