American Journal of Clinical Nutrition, Год журнала: 2023, Номер 118(6), С. 1239 - 1240
Опубликована: Окт. 31, 2023
Язык: Английский
Journal of Stomatology Oral and Maxillofacial Surgery, Год журнала: 2025, Номер unknown, С. 102234 - 102234
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
4
Journal of College of Physicians And Surgeons Pakistan, Год журнала: 2023, Номер unknown, С. 625 - 632
Опубликована: Июнь 1, 2023
Objective: To compile a comprehensive national cancer registry report of Pakistan by merging and analysing registration data received from major functional registries in various parts Pakistan.
Язык: Английский
Процитировано
25
Cells, Год журнала: 2023, Номер 12(22), С. 2600 - 2600
Опубликована: Ноя. 10, 2023
This review on acne transcriptomics allows for deeper insights into the pathogenesis of and isotretinoin's mode action. Puberty-induced insulin-like growth factor 1 (IGF-1), insulin androgen signaling activate kinase AKT mechanistic target rapamycin complex (mTORC1). A Western diet (hyperglycemic carbohydrates milk/dairy products) also co-stimulates AKT/mTORC1 signaling. The AKT-mediated phosphorylation nuclear FoxO1 FoxO3 results in their extrusion cytoplasm, a critical switch which enhances transactivation lipogenic proinflammatory transcription factors, including receptor (AR), sterol regulatory element-binding (SREBF1), peroxisome proliferator-activated γ (PPARγ) signal transducer activator 3 (STAT3), but reduces FoxO1-dependent expression GATA binding protein 6 (GATA6), key infundibular keratinocyte homeostasis. p53-binding MDM2 promotes degradation p53. In contrast, isotretinoin p53, sebaceous glands patients. overexpression these proapoptotic factors explains desirable sebum-suppressive effect via induction sebocyte apoptosis depletion BLIMP1(+) progenitor cells; it its adverse effects, teratogenicity (neural crest cell apoptosis), reduced ovarian reserve (granulosa risk depression (the hypothalamic neurons), VLDL hyperlipidemia, intracranial hypertension dry skin.
Язык: Английский
Процитировано
22
Nutrients, Год журнала: 2024, Номер 16(1), С. 160 - 160
Опубликована: Янв. 3, 2024
In the context of nutrient-driven epigenetic alterations, food-derived miRNAs can be absorbed into circulatory system and organs recipients, especially humans, potentially contribute to modulating health diseases. Evidence suggests that food uptake, by carrying exogenous (xenomiRNAs), regulates individual miRNA profile, modifying redox homeostasis inflammatory conditions underlying pathological processes, such as type 2 diabetes mellitus, insulin resistance, metabolic syndrome, cancer. The capacity diet control levels comprehension unique characteristics dietary in terms gene expression regulation show important perspectives a strategy disease susceptibility via modifications refine clinical outcomes. However, absorption, stability, availability, roles are intriguing currently subject intense debate; additionally, there is restricted knowledge their physiological potential side effects. Within this framework, we provided up-to-date comprehensive on miRNAs’ potential, discussing latest advances controversial issues related role human modulators chronic syndromes.
Язык: Английский
Процитировано
8
Nutrients, Год журнала: 2024, Номер 16(13), С. 2007 - 2007
Опубликована: Июнь 25, 2024
Bovine colostrum provides newborn calves with strong passive immunity, which will further affect the immunity of their offspring. Compared other commercial dairy products, bovine emphasizes limit aflatoxin M1, pathogenic bacteria, microorganisms, antibiotics, stimulants, and items, so it is safe to use. There are many reports that use as a breast milk fortifier for preterm infants necessary immune support premature infants, but selection products chosen must be free Bacillus cereus because they very dangerous infants. This also used in more clinical research needed. At same time, should emphasized composition BC different from human colostrum, particular, main protein casein, while whey protein, especially α-lactalbumin, together ovalbumin still reference best biological value, muscles. Therefore, currently not complete substitute milk. In recent years, addition studies have found has immunomodulatory promoting effects adolescents, adults, elderly. suggests potential provide appropriate people all ages. this study aimed evaluate quality nutritional characteristics on three dimensions. The ages narrative review identified several classes immunoactive substances including immunoglobulins, cytokines, enzymes, compared mature milk, full-term demonstrate rich range components. addition, influencing factors affecting (immunoglobulin) were reviewed, was individual differences, environmental factors, processing methods had great impact BC. More importantly, reviewed detail (with an emphasis immunocompromised children neonates) evidence hopes above make understand health role having effect, at when seeing value future, limitations its application deeply re-explored, such lactose intolerance, allergies, etc., effective solutions wide colostrum.
Язык: Английский
Процитировано
8
Journal of the American Nutrition Association, Год журнала: 2025, Номер unknown, С. 1 - 17
Опубликована: Янв. 9, 2025
Breast cancer (BC) is one of the leading causes death and morbidity among women worldwide. Epidemiologic evidence shows that risk BC other chronic diseases decreases as proportion whole plant foods increases, while animal (fish, meat, poultry, eggs, seafood, dairy products) non–whole (e.g., refined grains, added sugars, French fries) in diet decreases. Whole include fruits, vegetables, roots, tubers, legumes, nuts, seeds from which no edible part has been removed to food added. A lowers insulin resistance, inflammation, excess body fat, cholesterol, insulin-like growth factor 1 sex hormone bioavailability; it also increases estrogen excretion, induces favorable changes gut microbiota, may favorably affect mammary microbiota composition decrease early menarche, all contributing reduced incidence, recurrence, mortality. This review explores connection between a mortality well potential mechanisms involved. Additionally, this compared with dietary approaches recommended for BC. seems optimal pattern overall disease prevention exclusively consists which, based on existing evidence, lead best health outcomes.
Язык: Английский
Процитировано
1
Biological Procedures Online, Год журнала: 2024, Номер 26(1)
Опубликована: Май 27, 2024
Abstract Exosomes are increasingly recognized as important mediators of intercellular communication in cancer biology. can be derived from cells well cellular components tumor microenvironment. After secretion, the exosomes carrying a wide range bioactive cargos ingested by local or distant recipient cells. The released act through variety mechanisms to elicit multiple biological effects and impact most if not all hallmarks cancer. Moreover, owing their excellent biocompatibility capability being easily engineered modified, currently exploited promising platform for targeted therapy. In this review, we first summarize current knowledge roles risk etiology, initiation progression cancer, underlying molecular mechanisms. aptamer-modified exosome therapy is then briefly introduced. We also discuss future directions emerging biology perspective
Язык: Английский
Процитировано
6
Current Oncology Reports, Год журнала: 2024, Номер 26(3), С. 191 - 199
Опубликована: Янв. 30, 2024
Язык: Английский
Процитировано
5
Journal of Cancer Research and Practice, Год журнала: 2024, Номер 11(1), С. 7 - 17
Опубликована: Янв. 1, 2024
Abstract Objective: Nutrition, lifestyle and environment are the main factors affecting risk of cancer global burden this disease. Although these generally recognized among general public medical professionals, exact root causes mechanisms involved not clearly defined with aim control, as a result, incidence rates increasing globally. The purpose study is to provide an overview factors, protective measures statistical data related cancer, considering causes. Data Sources: This article reviews literature address most important control associated prevention for some common types in lung, breast, colon, stomach, prostate, cervix, skin. Study Selection: To have reliable interpretation, latest statistics on age-standardized published by International Agency Research Cancer analyzed according specific Results: Understanding provides basis more effective approaches potential strategies. Conclusion: Many cases controlled nutritional, environmental identifying effectively controlling can be significantly reduced.
Язык: Английский
Процитировано
4
Frontiers in Nutrition, Год журнала: 2024, Номер 11
Опубликована: Сен. 2, 2024
Milk was a source of important nutrients for humans and especially children adolescents. The modern dairy animal production pattern had contributed to residual sex steroid hormones in milk. When this milk consumed by humans, these entered the body leading hormonal disruptions potentially increasing risk various types cancers. This article reviewed presence milk, their potential risks on human health, possible association with incidence breast prostate cancer. linkage between consumption cancers were described detail. present products could affect development progression Sex interact different signaling pathways, influencing carcinogenic cascades that eventually lead tumorigenesis. Given health risks, suggested appropriate products. included being mindful not just amount consumed, but also selected. More scientific exploration needed, review provided valuable insights health-conscious consumers ongoing discussion dietary guidelines health.
Язык: Английский
Процитировано
3