Exploring Endogenous Tryptamines: Overlooked Agents Against Fibrosis in Chronic Disease? A Narrative Review DOI Creative Commons
Hunter Korsmo

Livers, Год журнала: 2024, Номер 4(4), С. 615 - 637

Опубликована: Ноя. 28, 2024

Long regarded as illicit substances with no clinical value, N-dimethylated tryptamines—such N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, and bufotenine—have been found to produce naturally in a wide variety of species, including humans. Known for their psychoactive effects through serotonin receptors (5-HTRs), tryptamines are currently being reinvestigated clinically long-term benefits mental disorders. Endogenous tryptamine is methylated by indolethylamine-N-methyltransferase (INMT), which can then serve an agonist pro-survival pathways, such sigma non-opioid intracellular receptor 1 (SIGMAR1) signaling. Fibrogenic diseases, like metabolic-associated fatty liver disease (MAFLD), steatohepatitis (MASH), chronic kidney (CKD) have shown changes INMT SIGMAR1 activity the progression pathogenesis. At cellular level, endothelial cells fibroblasts express various tissues; however, little known about injury fibrosis. In this review, I will give overview biochemistry, molecular biology, current evidence INMT’s role hepatic fibrogenesis. also discuss pre-clinical findings N-methylated highlight new upcoming therapeutic strategies that may be adapted mitigating fibrogenic diseases. Finally, mention recent mutualistic gut bacteria influencing endogenous signaling metabolism.

Язык: Английский

The Kidney in Obesity: Current Evidence, Perspectives and Controversies DOI
Dimitris Kounatidis, Natalia G. Vallianou, Theodora Stratigou

и другие.

Current Obesity Reports, Год журнала: 2024, Номер 13(4), С. 680 - 702

Опубликована: Авг. 14, 2024

Язык: Английский

Процитировано

11

Trimethylamine N-oxide: a meta-organismal axis linking the gut and fibrosis DOI Creative Commons

Jae Woong Jang,

Emma Capaldi,

Tracy L. Smith

и другие.

Molecular Medicine, Год журнала: 2024, Номер 30(1)

Опубликована: Авг. 23, 2024

Abstract Background Tissue fibrosis is a common pathway to failure in many organ systems and the cellular molecular driver of myriad chronic diseases that are incompletely understood lack effective treatment. Recent studies suggest gut microbe-dependent metabolites might be involved initiation progression multiple systems. Main body manuscript In meta-organismal begins gut, microbiota convert dietary precursors such as choline, phosphatidylcholine, L-carnitine into trimethylamine (TMA), which absorbed subsequently converted N-oxide (TMAO) via host enzyme flavin-containing monooxygenase 3 (FMO3) liver. Chronic exposure elevated TMAO appears associated with vascular injury enhanced propensity diverse conditions, including kidney disease, heart failure, metabolic dysfunction-associated steatotic liver systemic sclerosis. Conclusion Despite high prevalence fibrosis, little known date about role dysbiosis its pathogenesis. This review summarizes recent important advances understanding complex metabolism functional pathologic highlights unanswered questions.

Язык: Английский

Процитировано

8

Diet patterns, gut microbiota and metabolic disorders: Perspectives and challenges DOI Creative Commons
Μaria Dalamaga, Christina Tsigalou

Metabolism Open, Год журнала: 2024, Номер 23, С. 100310 - 100310

Опубликована: Авг. 8, 2024

The worldwide surge in obesity and associated metabolic disorders is emerging as a significant public health issue for societies healthcare systems. Available evidence has shown that alterations the gut microbiota could be implicated pathogenesis of disorders. A healthy microbiome characterized by richness high microbial diversity. Gut affect how host responds to diet, conversely, may modify through changes dietary habits. Diet can impact alter composition, diversity, species over time. An unhealthy fat sugar, lead decreased reduced synthesis metabolites maintain permeability, damage mucus layer, increased bacterial translocation lipopolyssacharide which trigger endotoxemia, chronic subclinical inflammation Currently, diet on composition its involvement pathogenic mechanisms underlying one most promising areas research nutrition. This special gathered original articles topics related patterns, microbiota, well brief reports, reviews perspectives wider field translational clinical research. In particular, aim this Special Issue was present connecting with disorders, explore association, examine patterns influence relationship.

Язык: Английский

Процитировано

4

Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats DOI Creative Commons
Ahmed W. Al-Humadi, Carel W. le Roux, Neil G. Docherty

и другие.

Diabetology, Год журнала: 2025, Номер 6(1), С. 8 - 8

Опубликована: Янв. 20, 2025

Background: Choline (Ch) deprivation causes kidney injury and dysfunction, diabetic nephropathy is also known to be a complication of diabetes; thus, this interplay could potentially aggravate disease. Aim: This study aims examine the effect Ch-deprivation on severity in streptozotocin (STZ)-induced rats. Methods: Twenty-four adult male Wistar rats were divided into four groups: control (C), nondiabetic Ch-deprived (CD), (DM), (DM + CD). Diabetes was induced by intraperitoneal administration 50 mg/kg body weight STZ; through choline-deficient diet. Rats euthanized at week 5 study. Biochemical tests, renal histopathology, immunohistochemistry molecule-1 (KIM-1), vascular endothelial growth factor-A (VEGF-A) expression assessed. Results: DM CD groups demonstrated significant increases glucose levels homeostasis model insulin resistance (HOMA IR). Creatinine blood urea nitrogen significantly increased group compared control, homocysteine higher group. Kidney histopathology revealed that tubular necrosis, mesangial matrix expansion, fibrosis substantially all other groups, KIM-1 VEGF-A expressions most pronounced respectively. Conclusions: Ch affected function structure STZ-induced deficiency diabetes seem have synergistic effect, as evidenced biochemistry, immunohistochemistry. These findings highlight important role choline therapeutic strategies for treatment and, potentially, prevention chronic

Язык: Английский

Процитировано

0

Choline metabolism in ischemic stroke: An underappreciated "two-edged sword" DOI Creative Commons

Mengchen Yu,

Guohao Liu, Wenbo Chen

и другие.

Pharmacological Research, Год журнала: 2025, Номер 214, С. 107685 - 107685

Опубликована: Март 5, 2025

Ischemic stroke (IS) is an important cause of death and disability worldwide, but the molecular mechanisms involved are not fully understood. In this context, choline metabolism plays increasingly role in IS due to its multifaceted involving neuroprotection, neuroregeneration, inflammatory response, immune regulation, long-term health effects. With deepening research on metabolites, such as trimethylamine-N-oxide (TMAO), scientists have gradually realized key occurrence, development potential treatment IS. This review summarizes importance neuroprotection disease management, highlighting complexity affecting cerebrovascular through gut microbes. Although metabolites exhibit a protective effect, excessive intake increases some may confer risk, suggesting need carefully balance dietary intake. The purpose integrate existing results provide theoretical basis for further exploring mechanism, prognosis evaluation clinical intervention ischemic IS, hoping new perspective enlightenment formulation effective prevention strategies, promote comprehensive understanding heart brain optimize methods.

Язык: Английский

Процитировано

0

Choline electrochemical biosensor based on MWCNT-AuNPs and MWCNT-PANI composite nanomaterials DOI

Meizheng Li,

Meng‐Fei Luo, Jia An

и другие.

Microchemical Journal, Год журнала: 2025, Номер unknown, С. 113609 - 113609

Опубликована: Апрель 1, 2025

Язык: Английский

Процитировано

0

Determination of Choline-Containing Compounds in Rice Bran Fermented with <i>Aspergillus oryzae</i> Using Liquid Chromatography/Tandem Mass Spectrometry DOI Creative Commons
Masamitsu Maekawa,

Anna Iwahori,

Masaki Kumondai

и другие.

Mass Spectrometry, Год журнала: 2024, Номер 13(1), С. A0151 - A0151

Опубликована: Июль 30, 2024

Choline-containing compounds are essential nutrients for human activity, as they involved in many biological processes, including cell membrane organization, methyl group donation, neurotransmission, signal transduction, lipid transport, and metabolism. These normally obtained from food. Fermented brown rice bran with

Язык: Английский

Процитировано

0

Exploring Endogenous Tryptamines: Overlooked Agents Against Fibrosis in Chronic Disease? A Narrative Review DOI Creative Commons
Hunter Korsmo

Livers, Год журнала: 2024, Номер 4(4), С. 615 - 637

Опубликована: Ноя. 28, 2024

Long regarded as illicit substances with no clinical value, N-dimethylated tryptamines—such N,N-dimethyltryptamine, 5-methoxy-N,N-dimethyltryptamine, and bufotenine—have been found to produce naturally in a wide variety of species, including humans. Known for their psychoactive effects through serotonin receptors (5-HTRs), tryptamines are currently being reinvestigated clinically long-term benefits mental disorders. Endogenous tryptamine is methylated by indolethylamine-N-methyltransferase (INMT), which can then serve an agonist pro-survival pathways, such sigma non-opioid intracellular receptor 1 (SIGMAR1) signaling. Fibrogenic diseases, like metabolic-associated fatty liver disease (MAFLD), steatohepatitis (MASH), chronic kidney (CKD) have shown changes INMT SIGMAR1 activity the progression pathogenesis. At cellular level, endothelial cells fibroblasts express various tissues; however, little known about injury fibrosis. In this review, I will give overview biochemistry, molecular biology, current evidence INMT’s role hepatic fibrogenesis. also discuss pre-clinical findings N-methylated highlight new upcoming therapeutic strategies that may be adapted mitigating fibrogenic diseases. Finally, mention recent mutualistic gut bacteria influencing endogenous signaling metabolism.

Язык: Английский

Процитировано

0