The Kidney in Obesity: Current Evidence, Perspectives and Controversies
Current Obesity Reports,
Год журнала:
2024,
Номер
13(4), С. 680 - 702
Опубликована: Авг. 14, 2024
Язык: Английский
Trimethylamine N-oxide: a meta-organismal axis linking the gut and fibrosis
Jae Woong Jang,
Emma Capaldi,
Tracy L. Smith
и другие.
Molecular Medicine,
Год журнала:
2024,
Номер
30(1)
Опубликована: Авг. 23, 2024
Abstract
Background
Tissue
fibrosis
is
a
common
pathway
to
failure
in
many
organ
systems
and
the
cellular
molecular
driver
of
myriad
chronic
diseases
that
are
incompletely
understood
lack
effective
treatment.
Recent
studies
suggest
gut
microbe-dependent
metabolites
might
be
involved
initiation
progression
multiple
systems.
Main
body
manuscript
In
meta-organismal
begins
gut,
microbiota
convert
dietary
precursors
such
as
choline,
phosphatidylcholine,
L-carnitine
into
trimethylamine
(TMA),
which
absorbed
subsequently
converted
N-oxide
(TMAO)
via
host
enzyme
flavin-containing
monooxygenase
3
(FMO3)
liver.
Chronic
exposure
elevated
TMAO
appears
associated
with
vascular
injury
enhanced
propensity
diverse
conditions,
including
kidney
disease,
heart
failure,
metabolic
dysfunction-associated
steatotic
liver
systemic
sclerosis.
Conclusion
Despite
high
prevalence
fibrosis,
little
known
date
about
role
dysbiosis
its
pathogenesis.
This
review
summarizes
recent
important
advances
understanding
complex
metabolism
functional
pathologic
highlights
unanswered
questions.
Язык: Английский
Diet patterns, gut microbiota and metabolic disorders: Perspectives and challenges
Metabolism Open,
Год журнала:
2024,
Номер
23, С. 100310 - 100310
Опубликована: Авг. 8, 2024
The
worldwide
surge
in
obesity
and
associated
metabolic
disorders
is
emerging
as
a
significant
public
health
issue
for
societies
healthcare
systems.
Available
evidence
has
shown
that
alterations
the
gut
microbiota
could
be
implicated
pathogenesis
of
disorders.
A
healthy
microbiome
characterized
by
richness
high
microbial
diversity.
Gut
affect
how
host
responds
to
diet,
conversely,
may
modify
through
changes
dietary
habits.
Diet
can
impact
alter
composition,
diversity,
species
over
time.
An
unhealthy
fat
sugar,
lead
decreased
reduced
synthesis
metabolites
maintain
permeability,
damage
mucus
layer,
increased
bacterial
translocation
lipopolyssacharide
which
trigger
endotoxemia,
chronic
subclinical
inflammation
Currently,
diet
on
composition
its
involvement
pathogenic
mechanisms
underlying
one
most
promising
areas
research
nutrition.
This
special
gathered
original
articles
topics
related
patterns,
microbiota,
well
brief
reports,
reviews
perspectives
wider
field
translational
clinical
research.
In
particular,
aim
this
Special
Issue
was
present
connecting
with
disorders,
explore
association,
examine
patterns
influence
relationship.
Язык: Английский
Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats
Diabetology,
Год журнала:
2025,
Номер
6(1), С. 8 - 8
Опубликована: Янв. 20, 2025
Background:
Choline
(Ch)
deprivation
causes
kidney
injury
and
dysfunction,
diabetic
nephropathy
is
also
known
to
be
a
complication
of
diabetes;
thus,
this
interplay
could
potentially
aggravate
disease.
Aim:
This
study
aims
examine
the
effect
Ch-deprivation
on
severity
in
streptozotocin
(STZ)-induced
rats.
Methods:
Twenty-four
adult
male
Wistar
rats
were
divided
into
four
groups:
control
(C),
nondiabetic
Ch-deprived
(CD),
(DM),
(DM
+
CD).
Diabetes
was
induced
by
intraperitoneal
administration
50
mg/kg
body
weight
STZ;
through
choline-deficient
diet.
Rats
euthanized
at
week
5
study.
Biochemical
tests,
renal
histopathology,
immunohistochemistry
molecule-1
(KIM-1),
vascular
endothelial
growth
factor-A
(VEGF-A)
expression
assessed.
Results:
DM
CD
groups
demonstrated
significant
increases
glucose
levels
homeostasis
model
insulin
resistance
(HOMA
IR).
Creatinine
blood
urea
nitrogen
significantly
increased
group
compared
control,
homocysteine
higher
group.
Kidney
histopathology
revealed
that
tubular
necrosis,
mesangial
matrix
expansion,
fibrosis
substantially
all
other
groups,
KIM-1
VEGF-A
expressions
most
pronounced
respectively.
Conclusions:
Ch
affected
function
structure
STZ-induced
deficiency
diabetes
seem
have
synergistic
effect,
as
evidenced
biochemistry,
immunohistochemistry.
These
findings
highlight
important
role
choline
therapeutic
strategies
for
treatment
and,
potentially,
prevention
chronic
Язык: Английский
Choline metabolism in ischemic stroke: An underappreciated "two-edged sword"
Pharmacological Research,
Год журнала:
2025,
Номер
214, С. 107685 - 107685
Опубликована: Март 5, 2025
Ischemic
stroke
(IS)
is
an
important
cause
of
death
and
disability
worldwide,
but
the
molecular
mechanisms
involved
are
not
fully
understood.
In
this
context,
choline
metabolism
plays
increasingly
role
in
IS
due
to
its
multifaceted
involving
neuroprotection,
neuroregeneration,
inflammatory
response,
immune
regulation,
long-term
health
effects.
With
deepening
research
on
metabolites,
such
as
trimethylamine-N-oxide
(TMAO),
scientists
have
gradually
realized
key
occurrence,
development
potential
treatment
IS.
This
review
summarizes
importance
neuroprotection
disease
management,
highlighting
complexity
affecting
cerebrovascular
through
gut
microbes.
Although
metabolites
exhibit
a
protective
effect,
excessive
intake
increases
some
may
confer
risk,
suggesting
need
carefully
balance
dietary
intake.
The
purpose
integrate
existing
results
provide
theoretical
basis
for
further
exploring
mechanism,
prognosis
evaluation
clinical
intervention
ischemic
IS,
hoping
new
perspective
enlightenment
formulation
effective
prevention
strategies,
promote
comprehensive
understanding
heart
brain
optimize
methods.
Язык: Английский
Choline electrochemical biosensor based on MWCNT-AuNPs and MWCNT-PANI composite nanomaterials
Microchemical Journal,
Год журнала:
2025,
Номер
unknown, С. 113609 - 113609
Опубликована: Апрель 1, 2025
Язык: Английский
Determination of Choline-Containing Compounds in Rice Bran Fermented with <i>Aspergillus oryzae</i> Using Liquid Chromatography/Tandem Mass Spectrometry
Mass Spectrometry,
Год журнала:
2024,
Номер
13(1), С. A0151 - A0151
Опубликована: Июль 30, 2024
Choline-containing
compounds
are
essential
nutrients
for
human
activity,
as
they
involved
in
many
biological
processes,
including
cell
membrane
organization,
methyl
group
donation,
neurotransmission,
signal
transduction,
lipid
transport,
and
metabolism.
These
normally
obtained
from
food.
Fermented
brown
rice
bran
with
Язык: Английский
Exploring Endogenous Tryptamines: Overlooked Agents Against Fibrosis in Chronic Disease? A Narrative Review
Livers,
Год журнала:
2024,
Номер
4(4), С. 615 - 637
Опубликована: Ноя. 28, 2024
Long
regarded
as
illicit
substances
with
no
clinical
value,
N-dimethylated
tryptamines—such
N,N-dimethyltryptamine,
5-methoxy-N,N-dimethyltryptamine,
and
bufotenine—have
been
found
to
produce
naturally
in
a
wide
variety
of
species,
including
humans.
Known
for
their
psychoactive
effects
through
serotonin
receptors
(5-HTRs),
tryptamines
are
currently
being
reinvestigated
clinically
long-term
benefits
mental
disorders.
Endogenous
tryptamine
is
methylated
by
indolethylamine-N-methyltransferase
(INMT),
which
can
then
serve
an
agonist
pro-survival
pathways,
such
sigma
non-opioid
intracellular
receptor
1
(SIGMAR1)
signaling.
Fibrogenic
diseases,
like
metabolic-associated
fatty
liver
disease
(MAFLD),
steatohepatitis
(MASH),
chronic
kidney
(CKD)
have
shown
changes
INMT
SIGMAR1
activity
the
progression
pathogenesis.
At
cellular
level,
endothelial
cells
fibroblasts
express
various
tissues;
however,
little
known
about
injury
fibrosis.
In
this
review,
I
will
give
overview
biochemistry,
molecular
biology,
current
evidence
INMT’s
role
hepatic
fibrogenesis.
also
discuss
pre-clinical
findings
N-methylated
highlight
new
upcoming
therapeutic
strategies
that
may
be
adapted
mitigating
fibrogenic
diseases.
Finally,
mention
recent
mutualistic
gut
bacteria
influencing
endogenous
signaling
metabolism.
Язык: Английский