Viability and stability evaluation of microencapsulated Lactobacillus reuteri in polysaccharide-based bionanocomposite
Carbohydrate Polymers,
Год журнала:
2024,
Номер
347, С. 122693 - 122693
Опубликована: Авг. 31, 2024
Язык: Английский
Postbiotic Sodium Butyrate Mitigates Hypertension and Kidney Dysfunction in Juvenile Rats Exposed to Microplastics
Antioxidants,
Год журнала:
2025,
Номер
14(3), С. 276 - 276
Опубликована: Фев. 26, 2025
Plastic
production
has
led
to
widespread
microplastic
(MP)
pollution,
with
children
more
vulnerable
MPs
than
adults.
However,
the
mechanisms
linking
MP
exposure
hypertension
and
kidney
disease
in
remain
unclear.
This
study
explored
whether
sodium
butyrate,
a
short-chain
fatty
acid
(SCFA)
antioxidant
anti-inflammatory
properties,
could
mitigate
MP-induced
damage
juvenile
rats.
Male
Sprague-Dawley
rats
(3
weeks
old)
were
randomly
assigned
four
groups
(n
=
8/group):
control,
low-dose
(1
mg/L),
high-dose
(10
butyrate
(400
mg/kg/day).
Rats
euthanized
at
12
weeks.
High-dose
impaired
function
increased
blood
pressure,
which
alleviated
by
through
reduced
oxidative
stress,
modulation
of
gut
microbiota,
plasma
butyric
levels,
enhanced
renal
SCFA-sensing
G
protein-coupled
receptor
43
expression.
Sodium
holds
potential
for
mitigating
reducing
modulating
elevating
levels.
Язык: Английский
Antibiotic-induced gut dysbiosis: unraveling the gut-heart axis and its impact on cardiovascular health
Molecular Biology Reports,
Год журнала:
2025,
Номер
52(1)
Опубликована: Март 17, 2025
Язык: Английский
Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(7), С. 2352 - 2352
Опубликована: Март 29, 2025
Atherosclerosis
remains
a
leading
cause
of
cardiovascular
morbidity
and
mortality
worldwide,
traditionally
linked
to
elevated
cholesterol
levels,
particularly
low-density
lipoprotein
(LDL-C).
However,
despite
aggressive
lipid-lowering
strategies,
residual
risk
persists,
underscoring
the
need
explore
additional
contributing
factors.
This
review
examines
emerging
factors
beyond
cholesterol,
including
chronic
inflammation,
gut
microbiota
composition,
oxidative
stress,
environmental
exposures.
Inflammation
plays
pivotal
role
in
atherogenesis,
with
markers
such
as
C-reactive
protein
(CRP),
interleukin-6
(IL-6),
tumor
necrosis
factor-alpha
(TNF-α)
serving
indicators
disease
activity.
The
microbiome,
metabolites
like
trimethylamine
N-oxide
(TMAO),
has
been
implicated
vascular
inflammation
plaque
development,
while
beneficial
short-chain
fatty
acids
(SCFAs)
demonstrate
protective
effects.
Oxidative
stress
further
exacerbates
endothelial
dysfunction
instability,
driven
by
reactive
oxygen
species
(ROS)
lipid
peroxidation.
Additionally,
factors,
air
pollution,
heavy
metal
exposure,
endocrine
disruptors,
psychological
have
emerged
significant
contributors
disease.
Understanding
these
novel
offers
broader
perspective
on
atherosclerosis
pathogenesis
provides
new
avenues
for
targeted
prevention
therapeutic
interventions.
Язык: Английский
The Role of the Gut Microbiota in Heart Failure: Pathophysiological Insights and Future Perspectives
Medicina,
Год журнала:
2025,
Номер
61(4), С. 720 - 720
Опубликована: Апрель 14, 2025
The
gut
microbiota
has
emerged
as
a
crucial
player
in
cardiovascular
diseases,
including
heart
failure
(HF).
Recent
studies
have
highlighted
the
bidirectional
interaction
between
and
heart,
often
referred
to
gut–heart
axis.
Dysbiosis,
characterized
by
alterations
microbial
composition
function,
been
linked
systemic
inflammation,
metabolic
disturbances,
impaired
homeostasis.
This
review
explores
mechanisms
through
which
influences
HF,
metabolite
production,
inflammatory
pathways,
endothelial
dysfunction,
hormonal
modulation,
fluid
retention,
sodium
absorption.
potential
therapeutic
implications
of
modulation
diet,
probiotics,
pharmacological
interventions
are
also
discussed.
Understanding
these
could
pave
way
for
novel
diagnostic
strategies
management
HF.
Future
research
should
focus
on
longitudinal
establish
causality
development
personalized
microbiota-based
interventions.
Язык: Английский
Gut microbiome and inflammation in cardiovascular drug response: trends in therapeutic success and commercial focus
Inflammopharmacology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 2, 2024
Язык: Английский
Protective Effect of Resveratrol on Kidney Disease and Hypertension Against Microplastics Exposure in Male Juvenile Rats
Antioxidants,
Год журнала:
2024,
Номер
13(12), С. 1457 - 1457
Опубликована: Ноя. 27, 2024
Global
pollution
stems
from
the
degradation
of
plastic
waste,
leading
to
generation
microplastics
(MPs).
While
environmental
pollutants
increase
risk
developing
hypertension
and
kidney
disease,
effects
MP
exposure
on
these
conditions
in
children
remain
unclear.
Resveratrol,
a
phenolic
compound
known
for
its
antihypertensive
renoprotective
properties,
has
gained
attention
as
potential
nutraceutical.
This
study
investigates
resveratrol
disease
induced
by
juvenile
rat
model.
Three-week-old
male
Sprague–-Dawley
(SD)
rats
were
randomly
allocated
into
four
groups
(n
=
8
per
group):
control
group,
low-dose
group
(1
mg/L),
high-dose
(10
receiving
(50
mg/L).
By
9
weeks
age,
resulted
elevated
blood
pressure
increased
creatinine
levels,
both
which
mitigated
treatment.
The
damage
linked
oxidative
stress,
effectively
prevented.
Additionally,
resveratrol’s
protective
against
associated
with
acetic
acid
reduced
renal
expression
Olfr78,
decreased
various
components
renin-angiotensin
system
(RAS).
Low-
exposure,
well
treatment,
differentially
influence
gut
microbiota
composition.
Our
findings
suggest
that
targeting
microbiota,
RAS
through
holds
therapeutic
preventing
exposure.
However,
further
research
is
needed
translate
results
clinical
applications.
Язык: Английский
Probiotic Applications of Bacillus subtilis
IntechOpen eBooks,
Год журнала:
2024,
Номер
unknown
Опубликована: Окт. 31, 2024
Probiotics
are
defined
as
live
microorganisms
that
confer
health
advantages
to
their
hosts.
Some
probiotics
exhibit
limitations,
including
susceptibility
temperature
fluctuations,
gastric
acidity,
and
harsh
conditions.
This
has
led
exploring
with
higher
intrinsic
resistance
stability
in
Bacillus
subtilis
received
attention
due
its
inherent
probiotic
properties,
high
conditions,
ability
form
spores.
Significant
progress
been
made
understanding
the
potential
of
B.
subtilis,
uncovering
various
mechanisms
action.
On
other
hand,
postbiotics
secreted
by
have
become
an
attractive
field
interest
for
scientists.
Numerous
studies
validated
efficacy
a
dietary
supplement
poultry
aquaculture.
Furthermore,
Food
Drug
Administration
(FDA)
recognized
safe.
These
advantageous
properties
position
highly
promising
applications.
Язык: Английский