Probiotic Applications of Bacillus subtilis DOI Creative Commons
Mohamadsadegh Mohamadzadeh,

Sakineh Abbaspour

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Probiotics are defined as live microorganisms that confer health advantages to their hosts. Some probiotics exhibit limitations, including susceptibility temperature fluctuations, gastric acidity, and harsh conditions. This has led exploring with higher intrinsic resistance stability in Bacillus subtilis received attention due its inherent probiotic properties, high conditions, ability form spores. Significant progress been made understanding the potential of B. subtilis, uncovering various mechanisms action. On other hand, postbiotics secreted by have become an attractive field interest for scientists. Numerous studies validated efficacy a dietary supplement poultry aquaculture. Furthermore, Food Drug Administration (FDA) recognized safe. These advantageous properties position highly promising applications.

Language: Английский

Viability and stability evaluation of microencapsulated Lactobacillus reuteri in polysaccharide-based bionanocomposite DOI
Mohamadsadegh Mohamadzadeh, Ahmad Fazeli, Ebrahim Vasheghani‐Farahani

et al.

Carbohydrate Polymers, Journal Year: 2024, Volume and Issue: 347, P. 122693 - 122693

Published: Aug. 31, 2024

Language: Английский

Citations

5
Postbiotic Sodium Butyrate Mitigates Hypertension and Kidney Dysfunction in Juvenile Rats Exposed to Microplastics DOI Creative Commons
You‐Lin Tain, Ying-Jui Lin, Chih‐Yao Hou

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(3), P. 276 - 276

Published: Feb. 26, 2025

Plastic production has led to widespread microplastic (MP) pollution, with children more vulnerable MPs than adults. However, the mechanisms linking MP exposure hypertension and kidney disease in remain unclear. This study explored whether sodium butyrate, a short-chain fatty acid (SCFA) antioxidant anti-inflammatory properties, could mitigate MP-induced damage juvenile rats. Male Sprague-Dawley rats (3 weeks old) were randomly assigned four groups (n = 8/group): control, low-dose (1 mg/L), high-dose (10 butyrate (400 mg/kg/day). Rats euthanized at 12 weeks. High-dose impaired function increased blood pressure, which alleviated by through reduced oxidative stress, modulation of gut microbiota, plasma butyric levels, enhanced renal SCFA-sensing G protein-coupled receptor 43 expression. Sodium holds potential for mitigating reducing modulating elevating levels.

Language: Английский

Citations

0
Antibiotic-induced gut dysbiosis: unraveling the gut-heart axis and its impact on cardiovascular health DOI
Navpreet Kaur, Pankaj Kumar,

Mahadev Dhami

et al.

Molecular Biology Reports, Journal Year: 2025, Volume and Issue: 52(1)

Published: March 17, 2025

Language: Английский

Citations

0
Beyond Cholesterol: Emerging Risk Factors in Atherosclerosis DOI Open Access
Makhabbat Bekbossynova, Timur Saliev, T Ivanova-Razumova

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2352 - 2352

Published: March 29, 2025

Atherosclerosis remains a leading cause of cardiovascular morbidity and mortality worldwide, traditionally linked to elevated cholesterol levels, particularly low-density lipoprotein (LDL-C). However, despite aggressive lipid-lowering strategies, residual risk persists, underscoring the need explore additional contributing factors. This review examines emerging factors beyond cholesterol, including chronic inflammation, gut microbiota composition, oxidative stress, environmental exposures. Inflammation plays pivotal role in atherogenesis, with markers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α) serving indicators disease activity. The microbiome, metabolites like trimethylamine N-oxide (TMAO), has been implicated vascular inflammation plaque development, while beneficial short-chain fatty acids (SCFAs) demonstrate protective effects. Oxidative stress further exacerbates endothelial dysfunction instability, driven by reactive oxygen species (ROS) lipid peroxidation. Additionally, factors, air pollution, heavy metal exposure, endocrine disruptors, psychological have emerged significant contributors disease. Understanding these novel offers broader perspective on atherosclerosis pathogenesis provides new avenues for targeted prevention therapeutic interventions.

Language: Английский

Citations

0
The Role of the Gut Microbiota in Heart Failure: Pathophysiological Insights and Future Perspectives DOI Creative Commons
Francisco Epelde

Medicina, Journal Year: 2025, Volume and Issue: 61(4), P. 720 - 720

Published: April 14, 2025

The gut microbiota has emerged as a crucial player in cardiovascular diseases, including heart failure (HF). Recent studies have highlighted the bidirectional interaction between and heart, often referred to gut–heart axis. Dysbiosis, characterized by alterations microbial composition function, been linked systemic inflammation, metabolic disturbances, impaired homeostasis. This review explores mechanisms through which influences HF, metabolite production, inflammatory pathways, endothelial dysfunction, hormonal modulation, fluid retention, sodium absorption. potential therapeutic implications of modulation diet, probiotics, pharmacological interventions are also discussed. Understanding these could pave way for novel diagnostic strategies management HF. Future research should focus on longitudinal establish causality development personalized microbiota-based interventions.

Language: Английский

Citations

0
Gut microbiome and inflammation in cardiovascular drug response: trends in therapeutic success and commercial focus DOI
Firoz Anwar, Fahad A. Al‐Abbasi,

Omar A. Al-Bar

et al.

Inflammopharmacology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 2, 2024

Language: Английский

Citations

1
Protective Effect of Resveratrol on Kidney Disease and Hypertension Against Microplastics Exposure in Male Juvenile Rats DOI Creative Commons
You‐Lin Tain,

Guo‐Ping Chang‐Chien,

Shu-Fen Lin

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1457 - 1457

Published: Nov. 27, 2024

Global pollution stems from the degradation of plastic waste, leading to generation microplastics (MPs). While environmental pollutants increase risk developing hypertension and kidney disease, effects MP exposure on these conditions in children remain unclear. Resveratrol, a phenolic compound known for its antihypertensive renoprotective properties, has gained attention as potential nutraceutical. This study investigates resveratrol disease induced by juvenile rat model. Three-week-old male Sprague–-Dawley (SD) rats were randomly allocated into four groups (n = 8 per group): control group, low-dose group (1 mg/L), high-dose (10 receiving (50 mg/L). By 9 weeks age, resulted elevated blood pressure increased creatinine levels, both which mitigated treatment. The damage linked oxidative stress, effectively prevented. Additionally, resveratrol’s protective against associated with acetic acid reduced renal expression Olfr78, decreased various components renin-angiotensin system (RAS). Low- exposure, well treatment, differentially influence gut microbiota composition. Our findings suggest that targeting microbiota, RAS through holds therapeutic preventing exposure. However, further research is needed translate results clinical applications.

Language: Английский

Citations

1
Probiotic Applications of Bacillus subtilis DOI Creative Commons
Mohamadsadegh Mohamadzadeh,

Sakineh Abbaspour

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 31, 2024

Probiotics are defined as live microorganisms that confer health advantages to their hosts. Some probiotics exhibit limitations, including susceptibility temperature fluctuations, gastric acidity, and harsh conditions. This has led exploring with higher intrinsic resistance stability in Bacillus subtilis received attention due its inherent probiotic properties, high conditions, ability form spores. Significant progress been made understanding the potential of B. subtilis, uncovering various mechanisms action. On other hand, postbiotics secreted by have become an attractive field interest for scientists. Numerous studies validated efficacy a dietary supplement poultry aquaculture. Furthermore, Food Drug Administration (FDA) recognized safe. These advantageous properties position highly promising applications.

Language: Английский

Citations

0