L Endocrinologo, Год журнала: 2024, Номер unknown
Опубликована: Сен. 19, 2024
Nutrients, Год журнала: 2025, Номер 17(5), С. 741 - 741
Опубликована: Фев. 20, 2025
Bariatric surgery (BS) is an effective treatment for severe obesity and its related comorbidities, such as type 2 diabetes hypertension. However, the anatomical physiological changes associated with these procedures significantly increase risk of preoperative postoperative micronutrient deficiencies, which can lead to complications anemia, osteoporosis, neurological disorders. This narrative review examines prevalence clinical implications deficiencies in BS patients, well evidence-based strategies their prevention management. The most common include iron, vitamin B12, folate, calcium, D, fat-soluble vitamins (A, E, K). Procedures a hypoabsorptive component, Roux-en-Y gastric bypass (RYGB) biliopancreatic diversion duodenal switch (BPD/DS), pose higher risks compared restrictive like sleeve gastrectomy (SG). Effective involve correction continuous monitoring, tailored supplementation. long-term adherence supplementation tends decrease over time, influenced by behavioral socioeconomic factors. Hence, preventing managing are crucial success BS. While current guidelines provide valuable recommendations, many based on low-certainty evidence, underscoring need more robust studies. A multidisciplinary approach, combined innovative strategies, telemedicine, enhance achieve sustainable outcomes.
Язык: Английский
Процитировано
1
Journal of Endocrinological Investigation, Год журнала: 2024, Номер 47(12), С. 2889 - 2913
Опубликована: Сен. 18, 2024
Язык: Английский
Процитировано
3
Frontiers in Nutrition, Год журнала: 2025, Номер 12
Опубликована: Янв. 23, 2025
Diet has been proven to have significant impacts on the pathogenesis and treatment of osteoporosis. This review attempts elucidate current progress controversy surrounding ketogenic diet (KD) β-hydroxybutyrate (BHB) in osteoporosis offers a novel perspective prevention The broadly used epilepsy, diabetes, obesity, certain neoplasms by triggering ketone bodies, mainly BHB. However, most osteoporosis-related clinical preclinical studies, demonstrated detrimental effects inhibiting bone accumulation damaging microarchitecture. In contrast, BHB is thought ameliorate promoting osteoblastogenesis osteoclastogenesis. main purpose this summarize research hope that more basic experiments will focus similarities differences between
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(7), С. 1216 - 1216
Опубликована: Март 30, 2025
Background: Tirzepatide (TZP), a unimolecular dual agonist targeting glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1 receptors, is promising weight loss agent in obesity. The preservation of metabolically active fat-free mass (FFM), muscle strength (MS), resting metabolic rate (RMR) essential for optimizing fat (FM) reduction. Although TZP typically combined with low-calorie diet (LCD), its impact on FFM uncertain, studies MS RMR are lacking. Evidence suggests that Low-Energy Ketogenic Therapy (LEKT) may reduce FM while preserving FFM, MS, RMR. Therefore, this study aimed to compare the effects an LEKT LCD, both TZP, body (BW), FM, patients Methods: We prospectively compared either LCD or 60 obesity (n = 30 per group) over 12 weeks. BW, were measured at baseline after Clinical parameters, assessment dietary compliance, side also evaluated. Results: At 12-week follow-up, groups showed significant BW reduction from (TZP+LEKT, p 0.0289; TZP+LCD, 0.0278), no intergroup difference (p 0.665). Similarly, decreased significantly cohorts < 0.001; 0.0185), TZP+LEKT group achieving greater 0.042). However, TZP+LCD exhibited declines 0.0284), 0.0341), 0.001), whereas we did not observe any changes 0.487), 0.691), 0.263) group. Intergroup direct comparisons confirmed experienced reductions 0.0388), 0.046), 0.019). Conclusions: Based findings these preliminary data, able support hypothesis seems be superior promoting
Язык: Английский
Процитировано
0
Current Obesity Reports, Год журнала: 2025, Номер 14(1)
Опубликована: Апрель 3, 2025
This narrative review comprehensively analyzes VLEKT as an advanced nutritional strategy for obesity management. The focus is on the beneficial effects key disease organs, such adipose tissue and liver, well modulation of intestinal permeability its fundamental role in influencing gut microbiota inflammatory pathways. impact obesity-related comorbidities, including metabolic syndrome, cardiovascular disease, endocrine disorders, dysfunction-associated steatotic liver (MASLD), neurological kidney alterations, also investigated. Moreover, to assess wider application treatment, combination ketogenic regimes with additional strategies physical activity, bariatric surgery, digital health technologies examined. Despite promising clinical results, adherence potential deficiencies require careful follow-up individualized programming monitored by specialists. Future research should elucidating molecular mechanisms underlying physiological systems, long-term safety. Nevertheless, innovative approach offering a target-oriented highly effective people fighting against overweight associated medical complications. Obesity multifactorial chronic numerous comorbidities; given increasing prevalence, personalized intervention are crucial inhibit "obesity pandemic" according "food re-educational" protocol. Among dietary interventions, diet (KD) has attracted attention effectiveness weight management benefits. A variant, very low-calorie (VLCKD), more recently defined low-energy (VLEKD), combines benefits ketosis substantial calorie restriction, improving overall health.
Язык: Английский
Процитировано
0
Journal of Endocrinological Investigation, Год журнала: 2025, Номер unknown
Опубликована: Апрель 28, 2025
Язык: Английский
Процитировано
0
Nutrients, Год журнала: 2025, Номер 17(9), С. 1533 - 1533
Опубликована: Апрель 30, 2025
Background: Preoperative nutritional interventions, including low-calorie diets (LCDs) and very (VLCDs), are commonly implemented in metabolic bariatric surgery. This systematic review meta-analysis aimed to evaluate the efficacy safety of preoperative dietary interventions patients undergoing surgery, with primary outcomes perioperative complications, operative time, length hospital stay. Methods: A were conducted, studies that compared LCD VLCD regular adults The assessed Random- fixed effects models used for quantitative synthesis. Risk bias was evaluated using Cochrane Bias tool ROBINS-I, while certainty evidence GRADE approach. Results: Eight trials comprising 1197 included meta-analysis. VLCDs associated a significant reduction complications (OR 0.59; 95% CI: 0.37-0.94; p = 0.03), whereas LCDs showed no effect on 1.64; 0.71-3.78; 0.25). No time observed (MD -2.64 min; -6.01 0.73; 0.12). Hospital stay slightly reduced -0.17 days; 0.0001), though clinical significance remains uncertain. low, primarily due risk small sample sizes. Conclusions: may lower do not appear provide this benefit. However, is limited by methodological heterogeneity low certainty. Further high-quality needed establish optimal protocols.
Язык: Английский
Процитировано
0
Current Obesity Reports, Год журнала: 2025, Номер 14(1)
Опубликована: Май 13, 2025
Abstract Summary Dermatological diseases such as acne, hidradenitis suppurativa (HS), and psoriasis are driven by chronic inflammation oxidative stress. Emerging evidence highlights the role of nutrition in modulating these conditions, particularly through dietary patterns rich antioxidants, polyphenols, unsaturated fatty acids. Recent Findings The Mediterranean diet (MedDiet) has demonstrated potential benefits due to its anti-inflammatory immunomodulatory effects, while very low-energy ketogenic therapy (VLEKT) shown promise rapidly improving disease severity. Specific nutrients, including omega-3 acids, probiotics, micronutrients, may further contribute management. However, current literature is limited small-scale studies lack standardized guidelines. Purpose Review This Consensus Statement , developed collaboratively Italian Association Dietetics Clinical Nutrition (ADI), Society Dermatology Sexually Transmitted Diseases (SIDeMaST), Nutraceuticals (SINut), Club Ketodiets “KetoNut-SINut” Endocrinology (SIE), Nutrition, Hormones Metabolism aimed establish an evidence-based framework for medical (MNT) most common inflammatory skin diseases, HS psoriasis.
Язык: Английский
Процитировано
0
Current Obesity Reports, Год журнала: 2025, Номер 14(1)
Опубликована: Май 17, 2025
This narrative review aimed to provide an overview of the current evidence on impact various nutritional strategies body composition in people living with obesity (PLwO), particular attention fat mass (FM), fat-free (FFM), and distribution. Obesity is increasingly linked cardiometabolic complications, yet common diagnostic metrics such as index (BMI) do not capture changes FM or FFM. Recent studies highlight variable effects different dietary interventions compartments. High-protein ketogenic diets are associated greater preservation FFM reductions visceral adipose tissue (VAT), while Mediterranean diet shows promise for long-term adherence improvements metabolic health. Intermittent fasting time-restricted eating demonstrate efficacy reduction but present mixed results regarding retention sustainability. Dietary exert diverse PLwO, underscoring importance tailoring individual profiles health goals. Personalized nutrition approaches that prioritize lean VAT, along sustainable adherence, critical optimizing management beyond weight loss alone.
Язык: Английский
Процитировано
0
Reproductive Biology and Endocrinology, Год журнала: 2025, Номер 23(1)
Опубликована: Май 20, 2025
Язык: Английский
Процитировано
0