Frontiers in Physiology,
Год журнала:
2024,
Номер
15
Опубликована: Июнь 21, 2024
Male
and
female
mule
ducks
were
subjected
to
a
force-feeding
diet
induce
liver
steatosis
as
it
is
generally
done
only
with
male
for
the
production
of
foie
gras.
The
different
biochemical
measurements
indicated
that
course
hepatic
development
was
present
in
both
sexes
associated
huge
increase
weight
mainly
due
synthesis
accumulation
lipids
hepatocytes.
In
livers
ducks,
this
lipid
oxidative
stress
hypoxia.
However,
certain
specific
modifications
(kinetics
droplet
inflammation)
indicate
may
tolerate
less
well,
at
least
level.
This
contradiction
what
reported
concerning
induced
by
dietary
disturbances
mammals
but
could
be
explained
very
conditions
imposed
force-feeding.
Despite
this,
seems
entirely
feasible,
provided
final
quality
product
good
which
will
remain
demonstrated
future
studies.
The Egyptian Journal of Internal Medicine,
Год журнала:
2024,
Номер
36(1)
Опубликована: Фев. 12, 2024
Abstract
Background
Liver
fibrosis
results
from
chronic
liver
injury
and
is
characterized
by
excessive
deposition
of
extracellular
matrix
proteins
including
collagen.
It
can
progress
to
cirrhosis
failure.
Main
body
the
abstract
Multiple
cellular
signaling
pathways
drive
hepatic
stellate
cell
activation
fibrogenesis.
Advances
in
biomarkers,
imaging
modalities,
omics
platforms
enable
noninvasive
diagnosis
staging
fibrosis.
Emerging
antifibrotic
approaches
include
medications
like
pirfenidone,
obeticholic
acid,
monoclonal
antibodies
targeting
pro-fibrotic
mediators.
Cell
therapies
using
mesenchymal
stem
cells
demonstrate
potential
through
paracrine
immunosuppression.
Tissue-engineered
grafts
biomaterial
carriers
for
localized
drug
delivery
are
promising
technologies.
Microfluidic
liver-on-a-chip
with
patient-derived
provide
unprecedented
models
study
human
test
candidates.
Short
conclusion
Significant
has
elucidated
mechanisms
underlying
fibrogenesis
uncovered
novel
therapeutic
targets.
Ongoing
challenges
translating
preclinical
findings,
improving
efficacy,
enabling
personalized
precision
medicine
approaches.
Further
research
into
combinatorial
therapies,
tissue
engineering
technologies
will
advance
treatment
all
causes.
Current Obesity Reports,
Год журнала:
2024,
Номер
13(2), С. 242 - 255
Опубликована: Март 8, 2024
Abstract
Purpose
of
the
Review
To
summarize
published
data
on
association
between
glucocorticoids
and
metabolic
dysfunction-associated
steatotic
liver
disease
(MASLD),
focusing
possible
pathophysiological
links
related
treatment
considerations.
Recent
Findings
Glucocorticoids,
commonly
used
for
managing
many
inflammatory
autoimmune
diseases,
may
contribute
to
development
progression
MASLD.
Glucocorticoids
induce
hyperglycemia
hyperinsulinemia,
thus
increasing
systemic
hepatic
insulin
resistance,
a
hallmark
MASLD
pathogenesis.
Furthermore,
increase
adipose
tissue
lipolysis,
de
novo
lipogenesis
decrease
fatty
acid
β-oxidation,
promoting
development.
Preclinical
evidence
also
suggests
that
adversely
affect
inflammation
fibrosis.
11beta-hydroxysteroid
dehydrogenase
type
1
(11β-HSD1)
5α-reductase
are
implicated
in
link
MASLD,
former
enzyme
latter
reducing
glucocorticoid
action
liver.
Treatment
considerations
exist
due
pathogenic
Since
iatrogenic
hypercortisolism
is
common,
should
be
at
minimum
daily
dose
control
subjective
disease.
pharmacologic
inhibition
11β-HSD1
has
provided
favorable
results
both
preclinical
studies
early
MASH
clinical
trials.
Summary
closely
linked
pathophysiology,
with
specific
therapeutic
implications.
Nutrients,
Год журнала:
2025,
Номер
17(2), С. 320 - 320
Опубликована: Янв. 17, 2025
With
the
improvement
of
living
standards,
alcoholic
liver
disease
caused
by
long-term
drinking
has
been
a
common
multiple
disease.
Probiotic
interventions
may
help
mitigate
damage
alcohol
intake,
but
mechanisms
need
more
investigation.
This
study
involved
70
drinkers
(18-65
years
old,
consumption
≥20
g/day,
lasting
for
than
one
year)
who
were
randomly
assigned
to
either
BC99
group
or
placebo
group.
Two
groups
given
(3
1
×
1010
CFU)
g/day)
60
days,
respectively.
Before
and
after
intervention,
blood
routine
indicators,
function,
renal
inflammatory
factors
intestinal
flora
evaluated.
The
results
showed
that
intervention
with
Weizmannia
coagulans
reduced
levels
alanine
aminotransferase,
aspartate
glutamyl
transpeptidase,
serum
total
bilirubin,
urea
nitrogen,
uric
acid
'blood
nitrogen/creatinine'.
also
pro-inflammatory
TNF-α
IL-6
increased
anti-inflammatory
factor
IL-10.
analysis
regulated
imbalance
flora,
beneficial
bacteria
abundance
(Prevotella,
Faecalibacterium
Roseburia)
conditionally
pathogenic
(Escherichia-Shigella
Klebsiella).
Both
LEfSe
random
forest
indicated
increase
in
Muribaculaceae
induced
was
key
alleviating
alcohol-induced
damage.
These
findings
demonstrate
potential
alleviate
injury
provide
an
effective
strategy
protection
drinkers.
Biomedicines,
Год журнала:
2025,
Номер
13(2), С. 359 - 359
Опубликована: Фев. 4, 2025
The
investigation
of
biomarkers
for
metabolic
diseases
such
as
type
2
diabetes
mellitus
(T2DM)
and
dysfunction-associated
steatohepatitis
(MASH)
reveals
their
potential
advancing
disease
treatment
addressing
notable
overlap.
connection
between
MASH,
obesity,
T2DM
highlights
the
need
an
integrative
management
approach
mechanisms
like
insulin
resistance
chronic
inflammation.
Obesity
contributes
significantly
to
development
MASH
through
lipid
dysregulation,
resistance,
Selective
biomarker
targeting
offers
a
valuable
strategy
detecting
these
comorbidities.
Biomarkers
CRP,
IL-6,
TNF-α
serve
indicators
inflammation,
while
HOMA-IR,
fasting
insulin,
HbA1c
are
essential
evaluating
resistance.
Additionally,
triglycerides,
LDL,
HDL
crucial
comprehending
dysregulation.
Despite
growing
importance
digital
biomarkers,
challenges
in
research
methodologies
sample
variability
persist,
necessitating
further
studies
validate
diagnostic
tools
improve
health
interventions.
Future
opportunities
include
developing
non-invasive
panels,
using
multiomics,
machine
learning
enhance
prognoses
accuracy
therapeutic
outcomes.
Journal of Translational Medicine,
Год журнала:
2023,
Номер
21(1)
Опубликована: Авг. 24, 2023
Non-alcoholic
Fatty
Liver
Disease
(NAFLD),
now
better
known
as
Metabolic
(Dysfunction)-Associated
(MAFLD)
and
its
progression
to
Nonalcoholic
Steatohepatitis
(NASH),
more
recently
referred
(MASH)
are
the
most
common
causes
of
liver
failure
chronic
damage.
The
new
names
emphasize
metabolic
involvement
both
in
relation
function
pathological
features
with
extrahepatic
manifestations.
This
study
aims
explore
role
immunometabolic
enzyme
ATP
citrate
lyase
(ACLY),
a
critical
lipogenesis,
carbohydrate
metabolism,
gene
expression
inflammation.ACLY
was
investigated
TNFα-triggered
human
hepatocytes
PBMC-derived
macrophages
from
MASH
patients.
Evaluation
levels
carried
out
by
western
blotting
and/or
RT-qPCR.
In
presence
or
absence
ACLY
inhibitors,
ROS,
lipid
peroxidation
GSSG
oxidative
stress
biomarkers
were
quantified.
Chromatin
immunoprecipitation
(ChIP),
transient
transfections,
immunocytochemistry,
histone
acetylation
quantitation
used
investigate
reprogramming.
IL-6
IL-1β
quantified
Lumit
immunoassays.Mechanistically,
inhibition
reverted
accumulation
damage
while
reduced
secretion
inflammatory
cytokines
hepatocytes.
These
effects
impacted
not
only
on
metabolism
but
also
other
crucial
such
redox
status
production
mediators.
Moreover,
mRNA
together
those
malic
1
(ME1)
increased
patients
when
compared
age-matched
healthy
controls.
Remarkably,
combination
hydroxycitrate
(HCA),
natural
inhibitor,
red
wine
powder
(RWP)
significantly
lowered
ME1
amount
well
subjects
MASH.Collectively,
our
findings
for
first
time
highlight
broad
spectrum
functions
pathogenesis
diagnostic
therapeutic
potential
value.
iScience,
Год журнала:
2024,
Номер
27(2), С. 108837 - 108837
Опубликована: Янв. 9, 2024
Obstructive
sleep
apnea
(OSA)
induces
intermittent
hypoxia
(IH),
an
independent
risk
factor
for
non-alcoholic
fatty
liver
disease
(NAFLD).
While
the
molecular
links
between
IH
and
NAFLD
progression
are
unclear,
immune
cell-driven
inflammation
plays
a
crucial
role
in
pathogenesis.
Using
lean
mice
exposed
to
long-term
cohort
of
OSA
patients
(n
=
71),
we
conducted
comprehensive
hepatic
transcriptomics,
lipidomics,
targeted
serum
proteomics.
Significantly,
demonstrated
that
alone
can
induce
NASH
signatures
found
human
steatohepatitis
transcriptomic
data.
Biomarkers
(PPARs,
NRFs,
arachidonic
acid,
IL16,
IL20,
IFNB,
TNF-α)
associated
with
early
systemic
were
identified.
This
link
IH,
apnea,
merits
further
exploration
clinical
trials,
advocating
integrating
diagnosis
phenotyping.
Our
unique
offer
potential
diagnostic
treatment
response
markers,
highlighting
therapeutic
targets
comorbidity
OSA.
