Impact of Cortisol on Liver Fat and Metabolic Health in Adrenal Incidentalomas and Cushing's Syndrome DOI Creative Commons

Peng Yu,

Haoyue Yuan, Xiaomu Li

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 27, 2024

Abstract Objective To evaluate liver fat content in patients with non-functional adrenal incidentalomas (NFAI), mild autonomous cortisol secretion (MACS), and Cushing’s Syndrome (CS), assess its relationship levels. Methods This cross-sectional study used retrospective data from 103 NFAI patients, 100 MACS (F-1mgDST > 1.8 µg/dL) 59 CS. Abdominal CT scans measured hepatic splenic values to calculate the liver-to-spleen (L/S) ratio. Metabolic indicators including fasting blood glucose (FPG), LDL-C, HDL-C, HbA1c etc were measured. Mediation analysis was explore indirect effects of metabolic traits on cortisol-liver relationship. Results Patients included NFAI, MACS, had higher NAFLD prevalence (57%) than (26.2%, P < 0.001) but lower CS (66.1%, 0.001). associated (OR 3.83 OR 5.73, 0.01), adjusted for age, BMI, covariates. Midnight serum correlated L/S ratio (p HbA1C Triglyceride-glucose index (TyG) mediated 24.5% 49.5% association, respectively. FPG, HbA1C, HDL-c, TyG association between or Homeostasis model assessment insulin resistance (HOMA-IR), fructosamine, triglycerides while alkaline phosphatase did so Total cholesterol, ALT, AST, γ-GGT, insulin, uric acid not mediate association. Conclusion are linked significant disturbances, increased impaired lipid metabolism, contributing fatty liver.

Язык: Английский

High dietary Fructose Drives Metabolic Dysfunction-Associated Steatotic Liver Disease via Activating ubiquitin-specific peptidase 2/11β-hydroxysteroid dehydrogenase type 1 Pathway in Mice DOI Creative Commons
Chunlin Li, Meng Li, Sheng Wei

и другие.

International Journal of Biological Sciences, Год журнала: 2024, Номер 20(9), С. 3480 - 3496

Опубликована: Янв. 1, 2024

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of chronic liver-related morbidity and mortality. Though high fructose intake acknowledged as a metabolic hazard, its role in etiology MASLD requires further clarification. Here, we demonstrated that dietary drives development promotes progression mice, identified

Язык: Английский

Процитировано

4
Prevalence of metabolic syndrome in patients with inflammatory bowel disease: a meta-analysis on a global scale DOI Creative Commons
Krishnamachari Janani, Parsa Saberian,

Hardik Patel

и другие.

Journal of Health Population and Nutrition, Год журнала: 2025, Номер 44(1)

Опубликована: Апрель 9, 2025

Metabolic syndrome (MetS) is a cluster of metabolic abnormalities that increase the risk cardiovascular diseases (CVD). Patients with inflammatory bowel disease (IBD) may be at higher developing MetS due to chronic inflammation, altered adipokine profiles, and effects corticosteroid treatment. However, prevalence in IBD patients remains inconsistent across studies. This meta-analysis aims estimate compare its occurrence between Crohn's (CD) ulcerative colitis (UC). A systematic search was conducted PubMed, Scopus, Embase, Web Science from their inception up January 19, 2025. Eligible observational studies reporting were included. Meta-analysis performed using random-effects model, heterogeneity assessed via I² statistic. Comprehensive Meta-Analysis (CMA) software, version 4.0 used for analysis. The pooled 21.8% (95% CI: 14.3-31.6%). UC (32.7%, 95% 16.0-55.5%) compared CD (14.1%, 8.6-22.3%). had significantly odds than those (OR = 1.38, 1.03-1.85, P 0.02). Additionally, older without (MD: 9.89, 5.12-14.67, < 0.01). In summary, this reveals notable among IBD, particularly UC, where CD. analysis also shows tend older, suggesting age as contributing factor. These findings underscore need routine screening care, especially elderly patients.

Язык: Английский

Процитировано

0
Gut microbial enzymes and metabolic dysfunction-associated steatohepatitis: Function, mechanism, and therapeutic prospects DOI
Xi Luo, Kai Wang, Changtao Jiang

и другие.

Cell Host & Microbe, Год журнала: 2025, Номер unknown

Опубликована: Май 1, 2025

Язык: Английский

Процитировано

0
Dietary curcumin supplementation attenuates hepatic damage and function abnormality in a chronic corticosterone-induced stress model in broilers DOI

Xuemei Shan,

Xingyu Xu, Lijun Wang

и другие.

The Journal of Steroid Biochemistry and Molecular Biology, Год журнала: 2024, Номер 243, С. 106579 - 106579

Опубликована: Июль 19, 2024

Язык: Английский

Процитировано

2
Impact of cortisol on liver fat and metabolic health in adrenal incidentalomas and Cushing’s syndrome DOI
Peng Yu, Haoyue Yuan, Xiaomu Li

и другие.

Endocrine, Год журнала: 2024, Номер unknown

Опубликована: Сен. 25, 2024

Язык: Английский

Процитировано

1
Healthy Lifestyle Changes Improve Cortisol Levels and Liver Steatosis in MASLD Patients: Results from a Randomized Clinical Trial DOI Open Access

Claudia Beatrice Bagnato,

Antonella Bianco, Caterina Bonfiglio

и другие.

Nutrients, Год журнала: 2024, Номер 16(23), С. 4225 - 4225

Опубликована: Дек. 6, 2024

Steatotic liver disease associated with metabolic dysfunction (MASLD) affects up to about 30% of the general adult population and is closely related obesity syndrome. Cortisol, a stress-related hormone contributing hepatic fat accumulation insulin resistance, also promotes progression disease. The study aims investigate impact lifestyle modifications on cortisol levels steatosis in patients MASLD.

Язык: Английский

Процитировано

1
Dietary Cholest-4-en-3-one, a Cholesterol Metabolite of Gut Microbiota, Alleviates Hyperlipidemia, Hepatic Cholesterol Accumulation, and Hyperinsulinemia in Obese, Diabetic db/db Mice DOI Creative Commons

Mina Higuchi,

Mai Okumura,

Sarasa Mitsuta

и другие.

Metabolites, Год журнала: 2024, Номер 14(6), С. 321 - 321

Опубликована: Июнь 3, 2024

Previous studies have shown that dietary cholest-4-en-3-one (4-cholestenone, 4-STN) exerts anti-obesity and lipid-lowering effects in mice. However, its underlying mechanisms are not fully understood. In the present study, we evaluated whether 4-STN supplementation would protect obese diabetic db/db mice from obesity-related metabolic disorders. After four weeks of feeding a 0.25% 4-STN-containing diet, was found to significantly alleviated hyperlipidemia, hepatic cholesterol accumulation, hyperinsulinemia; however, effect sufficient improve triglyceride accumulation or obesity. Further analysis demonstrated increased content free fatty acids neutral steroids feces mice, indicating alleviation hyperlipidemia by due an increase lipid excretion. addition, reduced levels desmosterol, precursor, plasma but liver, suggesting normalization metabolism is partly attributable suppression synthesis extrahepatic tissues. metabolites cholestanol (5α-cholestan-3β-ol) coprostanol (5β-cholestan-3β-ol). Our results show alleviates disorders, such as hyperinsulinemia,

Язык: Английский

Процитировано

0
Resveratrol analogues and metabolites selectively inhibit human and rat 11β-hydroxysteroid dehydrogenase 1 as the therapeutic drugs: structure–activity relationship and molecular dynamics analysis DOI
Chang‐Ping Hu, Ying Zhai, Han Lin

и другие.

SAR and QSAR in environmental research, Год журнала: 2024, Номер 35(7), С. 641 - 663

Опубликована: Июль 2, 2024

Resveratrol is converted to various metabolites by gut microbiota. Human and rat liver 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) are critical for glucocorticoid activation, while 11β-HSD2 in the kidney does opposite reaction. It still uncertain whether resveratrol its analogues selectively inhibit 11β-HSD1. In this study, inhibitory strength, mode of action, structure–activity relationship (SAR), docking analysis on human, rat, mouse 11β-HSD1 were performed. The strength these chemicals human was dihydropinosylvin (6.91 μM) > lunularin (45.44 pinostilbene (46.82 (171.1 pinosylvin (193.8 others. inhibiting (9.67 (17.39 (19.83 dihydroresveratrol (23.07 dihydroxystilbene (27.84 others (85.09 (>100 inhibited All did not 11β-HSD2. found that dihydropinosylvin, lunularin, competitive inhibitors pinostilbene, mixed Docking showed they bind steroid-binding site conclusion, can 11β-HSD1, insensitive inhibition analogues.

Язык: Английский

Процитировано

0
Blockade of 11β-hydroxysteroid dehydrogenase type 1 ameliorates metabolic dysfunction-associated steatotic liver disease and fibrosis DOI Creative Commons

Hwan Ma,

Guo-Yan Sui,

Jeong-Su Park

и другие.

Heliyon, Год журнала: 2024, Номер 10(20), С. e39534 - e39534

Опубликована: Окт. 1, 2024

Язык: Английский

Процитировано

0
Impact of Cortisol on Liver Fat and Metabolic Health in Adrenal Incidentalomas and Cushing's Syndrome DOI Creative Commons

Peng Yu,

Haoyue Yuan, Xiaomu Li

и другие.

Research Square (Research Square), Год журнала: 2024, Номер unknown

Опубликована: Авг. 27, 2024

Abstract Objective To evaluate liver fat content in patients with non-functional adrenal incidentalomas (NFAI), mild autonomous cortisol secretion (MACS), and Cushing’s Syndrome (CS), assess its relationship levels. Methods This cross-sectional study used retrospective data from 103 NFAI patients, 100 MACS (F-1mgDST > 1.8 µg/dL) 59 CS. Abdominal CT scans measured hepatic splenic values to calculate the liver-to-spleen (L/S) ratio. Metabolic indicators including fasting blood glucose (FPG), LDL-C, HDL-C, HbA1c etc were measured. Mediation analysis was explore indirect effects of metabolic traits on cortisol-liver relationship. Results Patients included NFAI, MACS, had higher NAFLD prevalence (57%) than (26.2%, P < 0.001) but lower CS (66.1%, 0.001). associated (OR 3.83 OR 5.73, 0.01), adjusted for age, BMI, covariates. Midnight serum correlated L/S ratio (p HbA1C Triglyceride-glucose index (TyG) mediated 24.5% 49.5% association, respectively. FPG, HbA1C, HDL-c, TyG association between or Homeostasis model assessment insulin resistance (HOMA-IR), fructosamine, triglycerides while alkaline phosphatase did so Total cholesterol, ALT, AST, γ-GGT, insulin, uric acid not mediate association. Conclusion are linked significant disturbances, increased impaired lipid metabolism, contributing fatty liver.

Язык: Английский

Процитировано

0