Journal of Molecular Histology, Год журнала: 2025, Номер 56(3)
Опубликована: Май 20, 2025
Язык: Английский
Obesity Medicine, Год журнала: 2025, Номер unknown, С. 100585 - 100585
Опубликована: Янв. 1, 2025
Язык: Английский
Процитировано
6
Nutrients, Год журнала: 2025, Номер 17(2), С. 320 - 320
Опубликована: Янв. 17, 2025
With the improvement of living standards, alcoholic liver disease caused by long-term drinking has been a common multiple disease. Probiotic interventions may help mitigate damage alcohol intake, but mechanisms need more investigation. This study involved 70 drinkers (18-65 years old, consumption ≥20 g/day, lasting for than one year) who were randomly assigned to either BC99 group or placebo group. Two groups given (3 1 × 1010 CFU) g/day) 60 days, respectively. Before and after intervention, blood routine indicators, function, renal inflammatory factors intestinal flora evaluated. The results showed that intervention with Weizmannia coagulans reduced levels alanine aminotransferase, aspartate glutamyl transpeptidase, serum total bilirubin, urea nitrogen, uric acid 'blood nitrogen/creatinine'. also pro-inflammatory TNF-α IL-6 increased anti-inflammatory factor IL-10. analysis regulated imbalance flora, beneficial bacteria abundance (Prevotella, Faecalibacterium Roseburia) conditionally pathogenic (Escherichia-Shigella Klebsiella). Both LEfSe random forest indicated increase in Muribaculaceae induced was key alleviating alcohol-induced damage. These findings demonstrate potential alleviate injury provide an effective strategy protection drinkers.
Язык: Английский
Процитировано
2
The Egyptian Journal of Internal Medicine, Год журнала: 2024, Номер 36(1)
Опубликована: Фев. 12, 2024
Abstract Background Liver fibrosis results from chronic liver injury and is characterized by excessive deposition of extracellular matrix proteins including collagen. It can progress to cirrhosis failure. Main body the abstract Multiple cellular signaling pathways drive hepatic stellate cell activation fibrogenesis. Advances in biomarkers, imaging modalities, omics platforms enable noninvasive diagnosis staging fibrosis. Emerging antifibrotic approaches include medications like pirfenidone, obeticholic acid, monoclonal antibodies targeting pro-fibrotic mediators. Cell therapies using mesenchymal stem cells demonstrate potential through paracrine immunosuppression. Tissue-engineered grafts biomaterial carriers for localized drug delivery are promising technologies. Microfluidic liver-on-a-chip with patient-derived provide unprecedented models study human test candidates. Short conclusion Significant has elucidated mechanisms underlying fibrogenesis uncovered novel therapeutic targets. Ongoing challenges translating preclinical findings, improving efficacy, enabling personalized precision medicine approaches. Further research into combinatorial therapies, tissue engineering technologies will advance treatment all causes.
Язык: Английский
Процитировано
11
Current Obesity Reports, Год журнала: 2024, Номер 13(2), С. 242 - 255
Опубликована: Март 8, 2024
Abstract Purpose of the Review To summarize published data on association between glucocorticoids and metabolic dysfunction-associated steatotic liver disease (MASLD), focusing possible pathophysiological links related treatment considerations. Recent Findings Glucocorticoids, commonly used for managing many inflammatory autoimmune diseases, may contribute to development progression MASLD. Glucocorticoids induce hyperglycemia hyperinsulinemia, thus increasing systemic hepatic insulin resistance, a hallmark MASLD pathogenesis. Furthermore, increase adipose tissue lipolysis, de novo lipogenesis decrease fatty acid β-oxidation, promoting development. Preclinical evidence also suggests that adversely affect inflammation fibrosis. 11beta-hydroxysteroid dehydrogenase type 1 (11β-HSD1) 5α-reductase are implicated in link MASLD, former enzyme latter reducing glucocorticoid action liver. Treatment considerations exist due pathogenic Since iatrogenic hypercortisolism is common, should be at minimum daily dose control subjective disease. pharmacologic inhibition 11β-HSD1 has provided favorable results both preclinical studies early MASH clinical trials. Summary closely linked pathophysiology, with specific therapeutic implications.
Язык: Английский
Процитировано
11
Biomedicines, Год журнала: 2025, Номер 13(2), С. 359 - 359
Опубликована: Фев. 4, 2025
The investigation of biomarkers for metabolic diseases such as type 2 diabetes mellitus (T2DM) and dysfunction-associated steatohepatitis (MASH) reveals their potential advancing disease treatment addressing notable overlap. connection between MASH, obesity, T2DM highlights the need an integrative management approach mechanisms like insulin resistance chronic inflammation. Obesity contributes significantly to development MASH through lipid dysregulation, resistance, Selective biomarker targeting offers a valuable strategy detecting these comorbidities. Biomarkers CRP, IL-6, TNF-α serve indicators inflammation, while HOMA-IR, fasting insulin, HbA1c are essential evaluating resistance. Additionally, triglycerides, LDL, HDL crucial comprehending dysregulation. Despite growing importance digital biomarkers, challenges in research methodologies sample variability persist, necessitating further studies validate diagnostic tools improve health interventions. Future opportunities include developing non-invasive panels, using multiomics, machine learning enhance prognoses accuracy therapeutic outcomes.
Язык: Английский
Процитировано
1
Biochemical Pharmacology, Год журнала: 2023, Номер 218, С. 115871 - 115871
Опубликована: Окт. 20, 2023
Язык: Английский
Процитировано
19
iScience, Год журнала: 2024, Номер 27(2), С. 108837 - 108837
Опубликована: Янв. 9, 2024
Obstructive sleep apnea (OSA) induces intermittent hypoxia (IH), an independent risk factor for non-alcoholic fatty liver disease (NAFLD). While the molecular links between IH and NAFLD progression are unclear, immune cell-driven inflammation plays a crucial role in pathogenesis. Using lean mice exposed to long-term cohort of OSA patients (n = 71), we conducted comprehensive hepatic transcriptomics, lipidomics, targeted serum proteomics. Significantly, demonstrated that alone can induce NASH signatures found human steatohepatitis transcriptomic data. Biomarkers (PPARs, NRFs, arachidonic acid, IL16, IL20, IFNB, TNF-α) associated with early systemic were identified. This link IH, apnea, merits further exploration clinical trials, advocating integrating diagnosis phenotyping. Our unique offer potential diagnostic treatment response markers, highlighting therapeutic targets comorbidity OSA.
Язык: Английский
Процитировано
8
Free Radical Biology and Medicine, Год журнала: 2024, Номер 221, С. 169 - 180
Опубликована: Май 21, 2024
Язык: Английский
Процитировано
8
Journal of Translational Medicine, Год журнала: 2023, Номер 21(1)
Опубликована: Авг. 24, 2023
Non-alcoholic Fatty Liver Disease (NAFLD), now better known as Metabolic (Dysfunction)-Associated (MAFLD) and its progression to Nonalcoholic Steatohepatitis (NASH), more recently referred (MASH) are the most common causes of liver failure chronic damage. The new names emphasize metabolic involvement both in relation function pathological features with extrahepatic manifestations. This study aims explore role immunometabolic enzyme ATP citrate lyase (ACLY), a critical lipogenesis, carbohydrate metabolism, gene expression inflammation.ACLY was investigated TNFα-triggered human hepatocytes PBMC-derived macrophages from MASH patients. Evaluation levels carried out by western blotting and/or RT-qPCR. In presence or absence ACLY inhibitors, ROS, lipid peroxidation GSSG oxidative stress biomarkers were quantified. Chromatin immunoprecipitation (ChIP), transient transfections, immunocytochemistry, histone acetylation quantitation used investigate reprogramming. IL-6 IL-1β quantified Lumit immunoassays.Mechanistically, inhibition reverted accumulation damage while reduced secretion inflammatory cytokines hepatocytes. These effects impacted not only on metabolism but also other crucial such redox status production mediators. Moreover, mRNA together those malic 1 (ME1) increased patients when compared age-matched healthy controls. Remarkably, combination hydroxycitrate (HCA), natural inhibitor, red wine powder (RWP) significantly lowered ME1 amount well subjects MASH.Collectively, our findings for first time highlight broad spectrum functions pathogenesis diagnostic therapeutic potential value.
Язык: Английский
Процитировано
17
Bioorganic Chemistry, Год журнала: 2024, Номер 147, С. 107400 - 107400
Опубликована: Апрель 25, 2024
Язык: Английский
Процитировано
6