Journal of Biosciences and Medicines,
Год журнала:
2023,
Номер
11(09), С. 90 - 113
Опубликована: Янв. 1, 2023
Long
COVID
has
been
studied
as
different
sequelae
that
some
individuals
can
develop
after
the
acute
phase
of
disease.
Persistent
symptoms
such
dry
cough,
fatigue,
and
dyspnea
remain
six
months
COVID-19
cure.
Others
lung
fibrosis,
kidney
injury,
thrombotic
risk
also
are
observed.
Here,
a
deep
review
each
human
organ
system
infected
by
virus
was
performed
aiming
to
show
how
molecules
expression
cell
signaling
induce
organism
cure
or
injuries
and,
subsequently
sequelae.
The
suggests
importance
public
health
surveillance
for
these
cases
including
more
comprehensive
analysis
molecular
biology
tools
clarify
assist
in
prognosis,
treatment,
preventive
methods
potentially
serious
disorders
post-COVID-19
patients.
Journal of Neuroimmunology,
Год журнала:
2024,
Номер
388, С. 578309 - 578309
Опубликована: Фев. 4, 2024
Blood-brain
barrier
(BBB)
permeability
can
cause
neuroinflammation
and
cognitive
impairment.
Caveolin-1
(Cav-1)
critically
regulates
BBB
permeability,
but
its
influence
on
the
consequent
neurological
outcomes
in
respiratory
viral
infections
is
unknown.
We
used
Cav-1-deficient
mice
with
genetically
encoded
fluorescent
endothelial
tight
junctions
to
determine
how
Cav-1
influences
neuroinflammation,
impairment
following
infection
mouse
adapted
(MA10)
SARS-CoV-2
as
a
model
for
COVID-19.
found
that
increased
brain
transcellular
albumin,
decreased
paracellular
Claudin-5
junctions,
caused
T
lymphocyte
infiltration
hippocampus,
region
important
learning
memory.
Concordantly,
we
observed
memory
deficits
infected
mice.
Importantly,
genetic
deficiency
attenuated
junction
losses,
infiltration,
gliosis
induced
by
infection.
Moreover,
KO
were
protected
from
These
results
establish
contribution
of
behavioral
dysfunction
neuroinflammation.
Annals of Clinical and Translational Neurology,
Год журнала:
2024,
Номер
11(9), С. 2457 - 2472
Опубликована: Июль 30, 2024
Abstract
Objective
The
aim
of
this
study
was
to
assess
COVID‐19‐related
gray
matter
(GM)
structural
alterations
in
two
distinct
groups
patients
presenting
with
the
prevailing
and
distinctive
neurological
symptoms
–
isolated
olfactory
disorders
as
sole
manifestation
(COVID‐OD)
cognitive
(COVID‐CD)
compared
a
control
group
unaffected
individuals.
Methods
included
61
COVID‐CD
(57
[60–63]
years,
62%
females),
84
COVID‐OD
(49
[35–57]
60%
17
controls
(51
[41–52]
41%
females).
Region‐based
morphometry
(RBM)
voxel‐based
(VBM)
were
performed
on
T1‐weighted
MRI
scans
GM
regional
volume
voxel‐wise
density
differences
between
COVID‐19
controls.
Surface‐based
(SBM)
applied
investigate
cortical
thickness
alterations.
statistical
models
built
among
total
intracranial
age
nuisance
variables.
Results
multi‐morphometric
analysis
revealed
statistically
significant
(
p
<
0.05
corrected
for
multiple
comparisons)
reduction
volumes,
both
patient
Across
all
three
analyses,
showed
more
distributed
severe
loss
than
patients.
most
prominently
affected
regions
hippocampus,
putamen,
cingulate
gyrus,
precuneus,
precentral
postcentral
gyri,
amygdala,
lingual
caudate
nucleus.
Interpretation
Our
findings
show
that
induce
atrophy,
although
at
different
degrees
severity,
likely
indicative
neurodegeneration
neuroinflammation.
Cardiopulmonary Physical Therapy Journal,
Год журнала:
2024,
Номер
36(1), С. 39 - 49
Опубликована: Дек. 30, 2024
Long
COVID
is
a
disabling
condition
which
affects
occupational
performance
and
quality
of
life.
It
interferes
with
activities
daily
living,
work,
many
meaningful
life
roles.
Cognitive
dysfunction
frequently
reported
symptom,
yet
it
commonly
overlooked.
important
that
cognitive
activity
considered
when
working
people
long
COVID,
particularly
identifying
triggers
post
exertional
symptom
exacerbation.
There
are
potential
mechanisms
could
be
driving
in
including
neuroinflammation,
viral
persistence,
vascular
damage,
orthostatic
intolerance.
to
consider
these
help
guide
intervention.
The
purpose
this
clinical
perspective
highlight
the
debilitating
impact
those
share
key
role
therapists
area.
may
missed
on
standardized
assessments
as
they
not
sensitive
enough
due
episodic
nature
symptoms.
Occupational
can
play
area
experts
assessing
providing
safe
assessment
rehabilitation.
medRxiv (Cold Spring Harbor Laboratory),
Год журнала:
2023,
Номер
unknown
Опубликована: Июль 23, 2023
Abstract
Coronavirus
disease
2019
(COVID-19)
has
been
associated
with
brain
functional,
structural,
and
cognitive
changes
that
persist
months
after
infection.
Most
studies
of
the
neurologic
outcomes
related
to
COVID-19
focus
on
severe
infection
aging
populations.
Here,
we
investigated
neural
activities
underlying
in
a
case-control
study
mildly
infected
youth
enrolled
longitudinal
Lombardy,
Italy,
global
hotspot
COVID-19.
All
participants
(13
cases,
27
controls,
mean
age
24
years)
completed
resting
state
functional
(fMRI),
structural
MRI,
assessments
(CANTAB
spatial
working
memory)
at
baseline
(pre-COVID)
follow-up
(post-COVID).
Using
graph
theory
eigenvector
centrality
(EC)
data-driven
statistical
methods,
examined
differences
EC
delta
(i.e.,
difference
values
pre-
post-COVID-19)
volumetric
cortical
volume
subcortical
areas
post-COVID)
between
cases
controls.
We
found
significantly
healthy
five
regions;
right
intracalcarine
cortex,
lingual
gyrus,
left
hippocampus,
amygdala,
frontal
orbital
cortex.
The
hippocampus
showed
significant
decrease
groups
(p=0.041).
reduced
amygdala
status
mediated
association
disrupted
memory.
Our
results
show
persistent
key
olfaction
cognition.
These
may
guide
treatment
efforts
assess
longevity,
reversibility
impact
observed
following
Biology,
Год журнала:
2024,
Номер
13(11), С. 907 - 907
Опубликована: Ноя. 7, 2024
Neurotrophins
(NTs)
constitute
a
family
of
small
protein
messengers
that
play
fundamental
role
in
both
the
central
and
peripheral
nervous
systems.
In
particular,
nerve
growth
factor
(NGF)
brain-derived
neurotrophic
(BDNF)
subtle
survival,
differentiation,
functioning
neuronal
populations,
as
well
fine
regulation
immune
functions.
The
SARS-CoV-2
infection
was
characterized
by
sequela
symptoms
(serious
respiratory
pathology,
inflammatory
storm,
neurological
discomfort,
up
to
less
serious
flu-like
symptoms),
which
caused,
at
end
2023,
more
than
7
million
deaths
worldwide.
Despite
official
pandemic,
physical
psychological
consequences
are
currently
object
scientific
research,
acute
chronic/long-lasting
(Long-COVID-19).
Given
multifactorial
nature
outcomes
adults
children,
several
studies
have
investigated
potential
involvement
NGF
BDNF
systems
pathology.
This
narrative
review
aims
summarize
most
recent
evidence
on
this
crucial
topic.
International Journal of Neuroscience,
Год журнала:
2024,
Номер
unknown, С. 1 - 9
Опубликована: Март 7, 2024
Coronavirus
disease
2019
(COVID-19)
can
be
a
critical
disease,
particularly
in
the
elderly
and
those
with
comorbidities.
Patients
Alzheimer's
are
more
vulnerable
to
COVID-19
consequences.
The
latest
results
have
indicated
some
common
risk
factors
for
both
diseases.
An
understanding
of
pathological
link
between
will
help
develop
timely
strategies
treat
This
review
explores
bidirectional
links
disease.
