Long COVID: A Molecular, Cellular and Histopathology Overview DOI Open Access
Bárbara Rafaela da Silva Barros,

Leonardo Carvalho de Oliveira Cruz,

Georon Ferreira de Sousa

et al.

Journal of Biosciences and Medicines, Journal Year: 2023, Volume and Issue: 11(09), P. 90 - 113

Published: Jan. 1, 2023

Long COVID has been studied as different sequelae that some individuals can develop after the acute phase of disease. Persistent symptoms such dry cough, fatigue, and dyspnea remain six months COVID-19 cure. Others lung fibrosis, kidney injury, thrombotic risk also are observed. Here, a deep review each human organ system infected by virus was performed aiming to show how molecules expression cell signaling induce organism cure or injuries and, subsequently sequelae. The suggests importance public health surveillance for these cases including more comprehensive analysis molecular biology tools clarify assist in prognosis, treatment, preventive methods potentially serious disorders post-COVID-19 patients.

Language: Английский

Caveolin-1 mediates blood-brain barrier permeability, neuroinflammation, and cognitive impairment in SARS-CoV-2 infection DOI Creative Commons
Troy N. Trevino, Ali A. Almousawi, KaReisha F. Robinson

et al.

Journal of Neuroimmunology, Journal Year: 2024, Volume and Issue: 388, P. 578309 - 578309

Published: Feb. 4, 2024

Blood-brain barrier (BBB) permeability can cause neuroinflammation and cognitive impairment. Caveolin-1 (Cav-1) critically regulates BBB permeability, but its influence on the consequent neurological outcomes in respiratory viral infections is unknown. We used Cav-1-deficient mice with genetically encoded fluorescent endothelial tight junctions to determine how Cav-1 influences neuroinflammation, impairment following infection mouse adapted (MA10) SARS-CoV-2 as a model for COVID-19. found that increased brain transcellular albumin, decreased paracellular Claudin-5 junctions, caused T lymphocyte infiltration hippocampus, region important learning memory. Concordantly, we observed memory deficits infected mice. Importantly, genetic deficiency attenuated junction losses, infiltration, gliosis induced by infection. Moreover, KO were protected from These results establish contribution of behavioral dysfunction neuroinflammation.

Language: Английский

Citations

9
Cognitive Aspects of COVID-19 DOI

Ezekiel Gonzalez‐Fernandez,

Juebin Huang

Current Neurology and Neuroscience Reports, Journal Year: 2023, Volume and Issue: 23(9), P. 531 - 538

Published: July 25, 2023

Language: Английский

Citations

13
COVID-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study DOI Creative Commons
Azzurra Invernizzi, Stefano Renzetti, Christoph van Thriel

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 2, 2024

Language: Английский

Citations

5
MRI evidence of gray matter loss in COVID‐19 patients with cognitive and olfactory disorders DOI Creative Commons
Serena Capelli, Alberto Arrigoni, Angela Napolitano

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2024, Volume and Issue: 11(9), P. 2457 - 2472

Published: July 30, 2024

Abstract Objective The aim of this study was to assess COVID‐19‐related gray matter (GM) structural alterations in two distinct groups patients presenting with the prevailing and distinctive neurological symptoms – isolated olfactory disorders as sole manifestation (COVID‐OD) cognitive (COVID‐CD) compared a control group unaffected individuals. Methods included 61 COVID‐CD (57 [60–63] years, 62% females), 84 COVID‐OD (49 [35–57] 60% 17 controls (51 [41–52] 41% females). Region‐based morphometry (RBM) voxel‐based (VBM) were performed on T1‐weighted MRI scans GM regional volume voxel‐wise density differences between COVID‐19 controls. Surface‐based (SBM) applied investigate cortical thickness alterations. statistical models built among total intracranial age nuisance variables. Results multi‐morphometric analysis revealed statistically significant ( p < 0.05 corrected for multiple comparisons) reduction volumes, both patient Across all three analyses, showed more distributed severe loss than patients. most prominently affected regions hippocampus, putamen, cingulate gyrus, precuneus, precentral postcentral gyri, amygdala, lingual caudate nucleus. Interpretation Our findings show that induce atrophy, although at different degrees severity, likely indicative neurodegeneration neuroinflammation.

Language: Английский

Citations

3
More than “Brain Fog”: Cognitive Dysfunction and the Role of Occupational Therapy in Long COVID DOI

Helen Skiffington,

Ciara Breen

Cardiopulmonary Physical Therapy Journal, Journal Year: 2024, Volume and Issue: 36(1), P. 39 - 49

Published: Dec. 30, 2024

Long COVID is a disabling condition which affects occupational performance and quality of life. It interferes with activities daily living, work, many meaningful life roles. Cognitive dysfunction frequently reported symptom, yet it commonly overlooked. important that cognitive activity considered when working people long COVID, particularly identifying triggers post exertional symptom exacerbation. There are potential mechanisms could be driving in including neuroinflammation, viral persistence, vascular damage, orthostatic intolerance. to consider these help guide intervention. The purpose this clinical perspective highlight the debilitating impact those share key role therapists area. may missed on standardized assessments as they not sensitive enough due episodic nature symptoms. Occupational can play area experts assessing providing safe assessment rehabilitation.

Language: Английский

Citations

2
Covid-19 related cognitive, structural and functional brain changes among Italian adolescents and young adults: a multimodal longitudinal case-control study DOI Creative Commons
Azzurra Invernizzi, Stefano Renzetti, Christoph van Thriel

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: July 23, 2023

Abstract Coronavirus disease 2019 (COVID-19) has been associated with brain functional, structural, and cognitive changes that persist months after infection. Most studies of the neurologic outcomes related to COVID-19 focus on severe infection aging populations. Here, we investigated neural activities underlying in a case-control study mildly infected youth enrolled longitudinal Lombardy, Italy, global hotspot COVID-19. All participants (13 cases, 27 controls, mean age 24 years) completed resting state functional (fMRI), structural MRI, assessments (CANTAB spatial working memory) at baseline (pre-COVID) follow-up (post-COVID). Using graph theory eigenvector centrality (EC) data-driven statistical methods, examined differences EC delta (i.e., difference values pre- post-COVID-19) volumetric cortical volume subcortical areas post-COVID) between cases controls. We found significantly healthy five regions; right intracalcarine cortex, lingual gyrus, left hippocampus, amygdala, frontal orbital cortex. The hippocampus showed significant decrease groups (p=0.041). reduced amygdala status mediated association disrupted memory. Our results show persistent key olfaction cognition. These may guide treatment efforts assess longevity, reversibility impact observed following

Language: Английский

Citations

6
Brain Mechanisms Involved in Post COVID Syndrome: A Narrative Review DOI Creative Commons

N. V. Gulyaeva

Neurochemical Journal, Journal Year: 2024, Volume and Issue: 18(3), P. 397 - 405

Published: Sept. 1, 2024

Language: Английский

Citations

1
Nerve Growth Factor and Brain-Derived Neurotrophic Factor in COVID-19 DOI Creative Commons
Carla Petrella, Giampiero Ferraguti, Luigi Tarani

et al.

Biology, Journal Year: 2024, Volume and Issue: 13(11), P. 907 - 907

Published: Nov. 7, 2024

Neurotrophins (NTs) constitute a family of small protein messengers that play fundamental role in both the central and peripheral nervous systems. In particular, nerve growth factor (NGF) brain-derived neurotrophic (BDNF) subtle survival, differentiation, functioning neuronal populations, as well fine regulation immune functions. The SARS-CoV-2 infection was characterized by sequela symptoms (serious respiratory pathology, inflammatory storm, neurological discomfort, up to less serious flu-like symptoms), which caused, at end 2023, more than 7 million deaths worldwide. Despite official pandemic, physical psychological consequences are currently object scientific research, acute chronic/long-lasting (Long-COVID-19). Given multifactorial nature outcomes adults children, several studies have investigated potential involvement NGF BDNF systems pathology. This narrative review aims summarize most recent evidence on this crucial topic.

Language: Английский

Citations

1
Vagus nerve stimulation for long COVID DOI
Claire-Marie Rangon

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 383 - 392

Published: Nov. 22, 2024

Language: Английский

Citations

1
The bidirectional links between coronavirus disease 2019 and Alzheimer’s disease DOI
Ali Nouraeinejad

International Journal of Neuroscience, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9

Published: March 7, 2024

Coronavirus disease 2019 (COVID-19) can be a critical disease, particularly in the elderly and those with comorbidities. Patients Alzheimer's are more vulnerable to COVID-19 consequences. The latest results have indicated some common risk factors for both diseases. An understanding of pathological link between will help develop timely strategies treat This review explores bidirectional links disease.

Language: Английский

Citations

0